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51.
Iterative extended Hükel calculations for all valence electrons and iterative PPP calculations in the variable electronegativity formalism for -electrons were performed on benzene, pyridine, fluorobenzene, and the pyrylium ion. The charge distributions for all compounds were found more uniform and plausible with the iteration procedures than without. Polarization effects from the-electrons were found to be of importance for the -electrons. The lone-pair picture of the highest occupied MO in pyridine is preserved in the iterative extended Hückel method, and two lone-pairs were obtained on the fluorine atom of fluorobenzene. The results indicate that this atom is not hybridized.
Sponsored in part by King Gustaf VI Adolfs 70-Years Fund for Swedish Culture, Knut and Alice Wallenberg's Foundation, and in part by the Swedish National Research Council. 相似文献
Zusammenfassung Benzol, Pyridin, Fluorbenzol und Pyriliumion wurden mit einer iterativen EH-Methode und einer iterativen PPP-VE-Methode berechnet. Es zeigte sich, daß Ladungsverteilungen bei Benutzung des Iterationsverfahrens besser beschrieben werden. Polarisationseffekte der-Elektronen auf die -Elektronen stellen sich als wichtig heraus. Auch in der IEH-Methode bleibt das oberste besetzte MO des Pyridins ein einsames Elektronenpaar. Am Fluoratom im Fluorbenzol werden zwei einsame-Elektronenpaare erhalten. Die Resultate führen zu der Annahme, daß dieses Atom nicht hybridisiert ist.
Resumé Des calculs par les méthodes itératives de Hückel étendu pour tous les électrons de valence et de PPP avec électronégativité variable pour les électrons ont été effectués pour le benzène, la pyridine, le fluorobenzène et l'ion pyrylium. Les distributions de charge pour tons ces composés sont plus uniformes et plus plausibles avec les procédés itératis que sans. Les électrons ont un effet de polarisation important sur les électrons . La plus haute orbitale occupée dans la pyridine reste identifiable comme la paire libre dans la méthode de Hückel étendue, et l'on obtient deux paires libres sur l'atome de fluor du fluorobenzène. Cet atome n'est pas hybride.
Sponsored in part by King Gustaf VI Adolfs 70-Years Fund for Swedish Culture, Knut and Alice Wallenberg's Foundation, and in part by the Swedish National Research Council. 相似文献
52.
We study wild embeddings of S
1 in S
n which are tame in a sense introduced by Quinn. We show that if is a finitely presented group with H
1()=H
2()=0, then any finiteness obstruction K
0() can be realized on the complement of such an embedded S
1. We also realize trivially symmetric K
–1() obstructions on the complements of such embeddings. For trivially symmetric , the embeddings constructed are shown to be isotopy homogeneous. 相似文献
53.
54.
Görgen JJ Comfort JR Tinsley JR Averett T DeKorse J Franklin B Ritchie BG Kyle G Klein A Berman B Burleson G Cranston K Faucett JA Jarmer JJ Knudson JN Penttilä S Tanaka N Brinkmöller B Dehnhard D Yen YF Hoibråten S Breuer H Flanders BS Khandaker MA Naples DL Zhang D Barlett ML Hoffmann GW Purcell M 《Physical review letters》1991,66(17):2193-2196
55.
W Nerdal A T Pedersen O M Andersen 《Acta chemica Scandinavica (Copenhagen, Denmark : 1989)》1992,46(9):872-876
Pelargonidin-3-glucoside has been isolated from the acidified methanolic extract of strawberries (Fragaria anannassa variety Corona) by successive application of an ion-exchange resin, droplet-counter chromatography and gel filtration. The pigment in acidified methanolic solution was studied by means of the two-dimensional nuclear Overhauser enhancement NMR technique, and the sugar unit was found to be attached to the 3-position on the aglycone. At +20 degrees C the pigment was found to be in the extreme narrowing limit where the NOESY cross-peaks are negative. However, at -20 degrees C this low-mass anthocyanin could be studied in the slow motion regime where the NOESY cross-peaks are positive. With a mixing time of 0.3 s, the glucose H1"-H4" proton pair was measured in the initial cross-relaxation rate and their cross-peak volume corresponded to the H1"-H4" distance found in a 4C1 chair conformation. 相似文献
56.
Adhemar Bultheel Pablo González-Vera Erik Hendriksen Olav Njåstad 《Numerical Algorithms》1992,3(1):91-104
Leta 1,...,a p be distinct points in the finite complex plane ?, such that |a j|>1,j=1,..., p and let \(b_j = 1/\bar \alpha _j ,\) j=1,..., p. Let μ0, μ π (j) , ν π (j) j=1,..., p;n=1, 2,... be given complex numbers. We consider the following moment problem. Find a distribution ψ on [?π, π], with infinitely many points of increase, such that $$\begin{array}{l} \int_{ - \pi }^\pi {d\psi (\theta ) = \mu _0 ,} \\ \int_{ - \pi }^\pi {\frac{{d\psi (\theta )}}{{(e^{i\theta } - a_j )^n }} = \mu _n^{(j)} ,} \int_{ - \pi }^\pi {\frac{{d\psi (\theta )}}{{(e^{i\theta } - b_j )^n }} = v_n^{(j)} ,} j = 1,...,p;n = 1,2,.... \\ \end{array}$$ It will be shown that this problem has a unique solution if the moments generate a positive-definite Hermitian inner product on the linear space of rational functions with no poles in the extended complex plane ?* outside {a 1,...,a p,b 1,...,b p}. 相似文献
57.
The kinetics of conversion of an edge-linked double cube, in this case [{Mo(3)PdS(4)(H(2)O)(9)}(2)](8+), to the corresponding single cube [Mo(3)(PdX)S(4)(H(2)O)(9)](4+), has been studied for the first time. Reaction is induced by six reagents X = CO, two water-soluble phosphines, Cl(-), Br(-), and NCS(-), which complex at the tetrahedral Pd. The first stage of reaction is fast and is accompanied by color changes, e.g. purple to dark blue in the case of Cl(-), assigned as double to single cube conversion. With X = CO and the two phosphines, when absorbance changes are intense enough for stopped-flow monitoring with reactants at =1 mM, rate constants 10(-)(5) k/M(-)(1) s(-)(1) at 25 degrees C are as follows: CO, 1.11; PTA, 27.8; P(C(6)H(4)SO(3))(3)(3)(-), 9.6; at I = 2.00 (Li(pts)). The reactions are independent of [H(+)] in the range 0.30-2.00 M, and no substitution at the Mo's is observed. The first stages with X = Cl(-), Br(-), and NCS(-) were too fast to monitor, but equilibrium constants K(1)/M(-)(1) were determined, Cl(-) (490), Br(-) (8040), and NCS(-) (630), by UV-vis spectrophotometry. Two subsequent kinetic stages are assigned to substitution at the Mo's. Similar behavior is observed for [Mo(3)FeS(4)(H(2)O)(10)](4+), which was selected because substitution at the Fe is also fast and there is no known double-cube formation. For both Mo(3)Pd and Mo(3)Fe the latter two stages can be explained by substitution at nonidentical (two alpha and one beta) H(2)O's on each Mo or by the presence of mixed-valent Mo(III)(2)Mo(IV) forms which are sufficiently long-lived to give a kinetic discrimination. In the case of NCS(-) an additional step, 0.015 s(-)(1), independent of [NCS(-)] is assigned to the isomerization Pd-NCS --> Pd-SCN. On removal of e.g. Cl(-) by chromatography or addition of Ag(+), the double cube re-forms. 相似文献
58.
Gert Eckhardt 《Journal of mass spectrometry : JMS》1979,14(1):31-35
Due to neighbouring group effects the behaviour under electron impact of amino ethers of the type RO(CH2)nNR1R2 is distinctly different from that of both simple ethers and amines. In addition to α-cleavages two further primary fragmentations can often be observed, one leading to [M–aldehyde]+. or [M–ketone]+. ions, the other (with n≥3) giving [M–R]+ ions. Both processes involve hydrogen rearrangements which were investigated by means of deuterium labelling. Their importance is strongly dependent upon the nature of the substituents R, R1, R2 and upon the length (n) of the carbon chain between the heteroatoms. This dependence can easily be explained by the fragmentation mechanisms put forward. 相似文献
59.
One of the most intriguing aspects of synthetic chemistry is the interplay of numerous dependent and independent variables en route to achieve a successful, high-yielding chemical transformation. The experienced synthetic chemist will probe many of these variables during reaction development and optimization, which will routinely involve investigation of reaction temperature, solvent, stoichiometry, concentration, time, choice of catalyst, addition sequence or quenching conditions just to name some commonly addressed variables. Remarkably, little attention is typically given to the choice of reaction vessel material as the surface of common laboratory borosilicate glassware is, incorrectly, assumed to be chemically inert. When reviewing the scientific literature, careful consideration of the vessel material is typically only given during the use of well-known glass-etching reagents such as HF, which is typically only handled in HF-resistant, polyfluorinated polymer vessels. However, there are examples of chemical transformations that do not involve such reagents but are still clearly influenced by the choice of reaction vessel material. In the following review, we wish to condense the most significant examples of vessel effects during chemical transformations as well as observations of container-dependent stability of certain molecules. While the primary focus is on synthetic organic chemistry, relevant examples from inorganic chemistry, polymerization reactions, atmospheric chemistry and prebiotic chemistry are also covered.One of the most intriguing aspects of synthetic chemistry is the interplay of numerous dependent and independent variables en route to achieve a successful, high-yielding chemical transformation. 相似文献
60.
Hawsar Othman Mohammed Attila Almsi Szilrd Molnr Pl Perjsi 《Molecules (Basel, Switzerland)》2022,27(13)
Hyperglycemia is reported to be associated with oxidative stress. It can result in changes in the activities of drug-metabolizing enzymes and membrane-integrated transporters, which can modify the fate of drugs and other xenobiotics; furthermore, it can result in the formation of non-enzyme catalyzed oxidative metabolites. The present work aimed to investigate how experimental hyperglycemia affects the intestinal and biliary appearance of the oxidative and Phase II metabolites of ibuprofen in rats. In vivo studies were performed by luminal perfusion of 250 μM racemic ibuprofen solution in control and streptozotocin-treated (hyperglycemic) rats. Analysis of the collected intestinal perfusate and bile samples was performed by HPLC-UV and HPLC-MS. No oxidative metabolites could be detected in the perfusate samples. The biliary appearance of ibuprofen, 2-hydroxyibuprofen, ibuprofen glucuronide, hydroxylated ibuprofen glucuronide, and ibuprofen taurate was depressed in the hyperglycemic animals. However, no specific non-enzymatic (hydroxyl radical initiated) hydroxylation product could be detected. Instead, the depression of biliary excretion of ibuprofen and ibuprofen metabolites turned out to be the indicative marker of hyperglycemia. The observed changes impact the pharmacokinetics of drugs administered in hyperglycemic individuals. 相似文献