STM images of a large organic molecule adsorbed on a bare metal substrate or on a thin insulating layer: Visualization of HOMO and LUMO

An isomer of the methylterrylene molecule was adsorbed both on Cu(111) and on a NaCl bilayer deposited on Cu(111) and imaged by ultra high vacuum scanning tunneling microscopy at low temperature (5 K). On the bare metal surface, the STM images do not reveal any intramolecular resolution and do not depend on the applied tunnel bias. On the contrary, the images acquired at specific bias voltages for the molecule on the salt layer show a striking similarity with the spatial distribution of the electronic probability density in the highest occupied molecular orbital (HOMO) and in the lowest unoccupied molecular orbital (LUMO) of free methylterrylene. They are well reproduced by elastic scattering quantum chemistry calculations. These data provide a direct view of the hyperconjugative interaction between the methyl group and the frontier orbitals of terrylene.     

A data-driven,high-throughput methodology to determine tissue-specific differentially methylated regions able to discriminate body fluids

Tissue-specific differentially methylated regions (tDMRs) are regions of the genome with methylation patterns that modulate gene expression in those tissue types. The detection of tDMRs in forensic evidence can permit the identification of body fluids at trace levels. In this report, we have performed a bioinformatic analysis of an existing array dataset to determine if new tDMRs could be identified for use in body fluid identification from forensic evidence. Once these sites were identified, primers were designed and bisulfite modification was performed. The relative methylation level for each body fluid at a given locus was then determined using qPCR with high-resolution melt analysis (HRM). After screening 127 tDMR's in multiple body fluids, we were able to identify four new markers able to discriminate blood (2 markers), vaginal epithelia (1 marker) and buccal cells (1 marker). One marker for each target body fluid was also tested with pyrosequencing showing results consistent with those obtained by HRM. This work successfully demonstrates the ability of in silico analysis to develop a novel set of tDMRs capable of being differentiated by real time PCR/HRM. The method can rapidly determine the body fluids left at crime scenes, assisting the triers of fact in forensic casework.     

Caminoside A,an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia

Extracts of the marine sponge Caminus sphaeroconia showed potent activity in a screen for bacterial type III secretion inhibitors. Bioassay guided fractionation of the extract led to the isolation of the novel antimicrobial glycolipid caminoside A (1). The structure of caminoside A was elucidated by analysis of spectroscopic data and chemical degradation.[structure: see text]     

Honeycomb pattern formation by laser-beam filamentation in atomic sodium vapor

We have observed transverse pattern formation leading to highly regular structures in both the near and far fields when a near-resonant laser beam propagates without feedback through an atomic sodium vapor. One example is a regular far-field honeycomb pattern, which results from the transformation of the laser beam within the vapor into a stable three-lobed structure with a uniform phase distribution and highly correlated power fluctuations. The predictions of a theoretical model of the filamentation process are in good agreement with these observations.     

Analysis of the Fenton-Karma model through an approximation by a one-dimensional map

The Fenton-Karma model is a simplification of complex ionic models of cardiac membrane that reproduces quantitatively many of the characteristics of heart cells; its behavior is simple enough to be understood analytically. In this paper, a map is derived that approximates the response of the Fenton-Karma model to stimulation in zero spatial dimensions. This map contains some amount of memory, describing the action potential duration as a function of the previous diastolic interval and the previous action potential duration. Results obtained from iteration of the map and numerical simulations of the Fenton-Karma model are in good agreement. In particular, the iterated map admits different types of solutions corresponding to various dynamical behavior of the cardiac cell, such as 1:1 and 2:1 patterns. (c) 2002 American Institute of Physics.     

Quantum mechanics and the local observer

A notion of local observer inspired by the work of Segal is introduced here in the Hilbert space theory of quantum mechanics. The local observer finds a mathematical place in the Hilbert space through local negation or complementation. A logicomathematical theory of local negation is presented and its implications for quantum logic and the problem of measurement are discussed. The setting is constructivist mathematics and the main result of the paper states that the introduction of a local observer implies the nonorthocomplementability of the whole Hilbert space even in the finite-dimensional case. Making a mathematical place for the observer (the “projector”) thus modifies the structure of the observables or the system of the projections, in accordance with a nonclassical theory of quantum-mechanical measurement.     

Fast causal information transmission in a medium with a slow group velocity

It is widely believed that the velocity of information upsiloni encoded on an optical pulse is equal to the group velocity upsilong, at least when upsilong is less than the speed of light in vacuum c. On the other hand, several authors suggest that upsiloni=c, although the size of the signal traveling at this velocity may be small, thereby making it difficult to measure. Here, we measure upsiloni for pulses propagating through a resonant "slow-light" medium where upsilong approximately 0.006c. We find upsiloni=1.03c(+0.49c)-0.25c, or that upsiloni approximately 168upsilong, clearly demonstrating that the speed of information cannot be generally described by upsilong, but is characterized by its own velocity.     

High order harmonic generation by non-linear reflection of a pedestal-free intense laser pulse on a plasma

We demonstrate the influence of the prepulses and ASE of ultrashort pulses interacting with a solid target by addressing the direct comparison of the harmonic spectra generated by reflection onto a solid target with and without the introduction of a plasma mirror system. Harmonics up to the 20th of the fundamental of the Ti-Sa laser are clearly visible in a situation free from any plasma expansion. PACS 42.65. Ky; 52.38.-r; 52.38.Ph; 52.50.Jm     

Time-resolved analysis of the X-ray emission of femtosecond-laser-produced plasmas in the 1.5-keV range

Recent experimental results on ion beams produced in high-intensity laser–solid interactions indicate the presence of very intense electric fields in the target. This suggests the possibility of efficiently heating a solid material by means of the fast electrons created during the laser–solid interactions and trapped in the target, rather than by the laser photons themselves. We tested this mechanism by irradiating very small cubic aluminum targets with the LULI 100-TW, 300-fs laser at 1.06-m wavelength. X-ray spectra were measured with an ultra-fast streak camera, coupled to a conical Bragg crystal, providing spectra in the 1.5-keV range with high temporal and spectral resolution. The results indicate the creation of a hot plasma, but a very low coupling between the rapid electrons and the solid. A tentative explanation, in agreement with other experimental results and with preliminary particle-in-cell (PIC) simulations, points out the fatal role of the laser prepulse. PACS 52.50.Jm; 52.38.Ph; 52.38.Kd