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51.
Snyder DA Chen Y Denissova NG Acton T Aramini JM Ciano M Karlin R Liu J Manor P Rajan PA Rossi P Swapna GV Xiao R Rost B Hunt J Montelione GT 《Journal of the American Chemical Society》2005,127(47):16505-16511
X-ray crystallography and NMR spectroscopy provide the only sources of experimental data from which protein structures can be analyzed at high or even atomic resolution. The degree to which these methods complement each other as sources of structural knowledge is a matter of debate; it is often proposed that small proteins yielding high quality, readily analyzed NMR spectra are a subset of those that readily yield strongly diffracting crystals. We have examined the correlation between NMR spectral quality and success in structure determination by X-ray crystallography for 159 prokaryotic and eukaryotic proteins, prescreened to avoid proteins providing polydisperse and/or aggregated samples. This study demonstrates that, across this protein sample set, the quality of a protein's [15N-1H]-heteronuclear correlation (HSQC) spectrum recorded under conditions generally suitable for 3D structure determination by NMR, a key predictor of the ability to determine a structure by NMR, is not correlated with successful crystallization and structure determination by X-ray crystallography. These results, together with similar results of an independent study presented in the accompanying paper (Yee, et al., J. Am. Chem. Soc., accompanying paper), demonstrate that X-ray crystallography and NMR often provide complementary sources of structural data and that both methods are required in order to optimize success for as many targets as possible in large-scale structural proteomics efforts. 相似文献
52.
Pietro Schenone Alberto Bargagna Gaetano Bignardi Filippo Evangelisti 《Journal of heterocyclic chemistry》1976,13(5):1105-1107
The reaction of 2-carbonyl-1,3-dithiane, a sulfene prepared in situ from 2-chloroearbonyl-1,3-dithiane and triethylamine, with N,N-disubstituted 2-aminomethylvnecycloalkanones gave the 1,4-cycloadducts, namely N,N-disubstituted 4′-aminospiro[1,3-dithiane-2,3′-(5′,6′-poly-methylene-3′,4′-dihydro-α-pyrones)]. 相似文献
53.
Monfrecola G Procaccini EM D'Onofrio D Roberti G Liuzzi R Staibano S Manco A De Rosa G Santoianni P 《Journal of photochemistry and photobiology. B, Biology》2002,68(2-3):147-155
Photodynamic therapy (PDT) with 5-aminolaevulinic acid (ALA) is an alternative tool for the treatment of superficial non-melanoma skin cancers. Recently ALA-PDT has been employed with encouraging results also for warts, condylomata and psoriasis. In this study the effects of topical ALA plus irradiation with visible light on intact human skin have been evaluated. Five skin areas (A, B, C, D, and E) on the inner upper part of the arms of five healthy volunteers (skin types III and IV) were treated with (A) ALA 20% in base cream without irradiation, (B) only the vehicle (base cream) without ALA, (C, D and E) ALA cream at the concentrations of 5, 10 and 20%, respectively; all treatments were applied with an occlusive dressing. Four hours after ALA or vehicle application areas B, C, D and E were irradiated with a fixed dose of 40 J/cm(2). ALA penetration through the intact skin was evaluated by in vivo fluorescence determination. The effects on healthy skin were evaluated by clinical and chromometric examinations, light microscopy, immunohistochemistry and electron microscopy. RESULTS: (1) in vivo fluorescence demonstrated that ALA is able to penetrate through the intact skin, when applied with occlusive dressing and induces a classical fluorescence peak due to Protoporphyrin IX (PpIX) formation, which is the active photosensitiser. (2) Skin areas receiving ALA plus irradiation showed erythema and swelling just after the irradiative session and hyperpigmentation 48-72 h later. (3) Colourimetric data confirmed significant skin colour changes: values a* (representing the erythematous changes) increased only on the skin areas where ALA+irradiation were applied and during the 48 h after irradiation, thereafter a* began to decrease; values L* (pigmentation) increased during the 2 weeks following treatment. (4) Histopathological, immunohistochemical (S100, HMB-45) and electron microscopic findings showed an absolute increment of the number of melanocytes, which appeared clearly activated. In conclusion the application of ALA cream followed by irradiation is able to induce a pigmentation response in healthy human skin, at least in skin types III and IV. This melanocytic activation could have a potential for the treatment of skin disorders characterised by hypopigmentation. 相似文献
54.
Ultrathin ordered titanium oxide films on a Pt(111) surface have been prepared by reactive deposition and characterized by low-energy electron diffraction and scanning tunneling microscopy (STM). According to the postdeposition annealing condition, three different phases have been prepared which show a wagon-wheel-like (hereafter ww) morphological pattern. Two of them can be prepared as single phases (w- and w'-TiO(x)) and one (w(int)-TiO(x)) as a mixed phase which always coexists with at least one of the other two phases. All of them are formed by a Ti-O bilayer, where the Ti atoms are located at the interface with the substrate, but they show a rather distinct STM ww pattern. The experimental STM contrast has been discussed on the basis of a Moiré-like model, i.e., as deriving from a modulation of the Ti occupancy of the different substrate sites (i.e., hollow, bridge and on-top sites). The major part of the STM data can be easily interpreted on the basis of this simplified model. 相似文献
55.
Anna Maria Almerico Gaetano Dattolo Girolamo Cirrincione Giuseppe Presti Enrico Aiello 《Journal of heterocyclic chemistry》1987,24(5):1309-1311
The title compounds were prepared by nitration of compounds 2 , reduction of the dinitro derivatives 4 and diazotization of the diamino derivatives 6 followed by an intramolecular coupling reaction. Compound 4a showed good activity against Salmonella cholerasuis and Clostridium perfringens bacteria. 相似文献
56.
The bioadhesive properties of a novel chemical hydrogel based on a polymer of protein-like structure, have been investigated by using ATR FT-IR spectroscopy. In particular, the copolymer PHG obtained by partial derivatization of PHEA with GMA was chemically crosslinked by UV irradiation at 313 nm. Crosslinked PHG was treated with water to obtain a swelled sample, named PHG-UV gel, that was brought into contact with a phosphate buffer/citric acid solution at pH 7.0 in the absence or in the presence of mucin at various concentrations (0.01, 0.1 and 1 wt.-%). Preliminary dynamic swelling studies have evidenced the occurrence of an interaction between the PHG-UV gel and the glycoprotein. This result was confirmed by ATR FT-IR measurements. A diffusion model using a solution of Ficks' second law was employed to determine the diffusion coefficient of water into PHG-UV gel as a consequence of adsorption and/or interdiffusion which occur at the PHG-UV gel/mucin solution interface. Experimental results suggest a potential use of PHG-UV gel to prepare bioadhesive devices. 相似文献
57.
Luca Stabellini Wei Lu Alfredo De Rossi Thomas Antoni Mathieu Carras Stefano Trillo Gaetano Bellanca 《Optical and Quantum Electronics》2008,40(14-15):1085-1090
A Finite Difference Time Domain approach is used to design and to optimize quantum-well based infrared photodetectors. Results showing the influence of some parameters on the performance of these devices are presented and discussed. 相似文献
58.
Francesco P. Ballistreri Lucia Brinchi Raimondo Germani Gianfranco Savelli Gaetano A. Tomaselli Rosa M. Toscano 《Tetrahedron》2008,64(44):10239-10243
An aqueous reaction medium, based on a surfactant solution of diethyltetradecylamine N-oxide (AOE-14), was developed for the enantioselective epoxidation of 1,2-dihydronaphthalene and of various cis-β-alkyl styrenes with increasing hydrophobicity, using bleach as oxidant and the Jacobsen chiral (salen)Mn(III) as catalyst. AOE-14 is able to both solubilize all reactants in water and bind the metal of the salen complex acting as coligand. Its use leads to good yields (>75%) and to ee values ranging from 75% up to 91% even in the case of cis-β-alkyl styrenes where lower cis/trans epoxide ratios are observed. The ratio of surfactant/substrate used is 1:1 or 4:1, much lower than those generally used in the literature. 相似文献
59.
Gaetano Assanto Catherine García-Reimbert Antonmaria A. Minzoni Noel F. Smyth Annette L. Worthy 《Physica D: Nonlinear Phenomena》2011,240(14-15):1213-1219
We investigate the interaction of three optical solitary waves propagating with angular momentum in bulk nematic liquid crystals. The resulting cluster of solitary waves, or nematicons, is shown to orbit about its common centre of “mass”. An elongated isosceles triangle configuration is derived, this solution being the equivalent of the Lagrange solution of Newtonian gravitation. This triangle solution is found to be stable owing to diffractive radiation. A modulation theory explains the existence of the triangle solution as due to the non-monotonicity of an effective potential for the interaction of the solitary waves. This modulation theory also gives good agreement with numerical solutions for the trajectories of the nematicons in the three colours. Finally, it is shown that a cut-off in the shed diffractive radiation prevents the break-up of the triangle due to radiative losses. 相似文献
60.