全文获取类型
收费全文 | 75篇 |
免费 | 3篇 |
专业分类
化学 | 37篇 |
数学 | 3篇 |
物理学 | 38篇 |
出版年
2021年 | 1篇 |
2018年 | 3篇 |
2016年 | 3篇 |
2014年 | 3篇 |
2012年 | 4篇 |
2011年 | 4篇 |
2010年 | 2篇 |
2009年 | 1篇 |
2008年 | 1篇 |
2007年 | 3篇 |
2006年 | 3篇 |
2005年 | 6篇 |
2004年 | 4篇 |
2003年 | 1篇 |
2002年 | 2篇 |
2001年 | 1篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1877年 | 4篇 |
1867年 | 1篇 |
排序方式: 共有78条查询结果,搜索用时 15 毫秒
61.
62.
Nadine Muller Robert Granet Lucette Lepage Pierre Krausz Jean‐Paul Laval 《Journal of heterocyclic chemistry》2001,38(6):1447-1452
The synthesis of a polycyclic heterocyclic ring system compound, ethyl 7‐hydroxy‐4‐oxo‐2‐phenyl‐4,5‐dihydro‐3H‐benzo[6,7]cyclohepta[1,2‐d]pyrimidine‐6‐carboxylate was carried out by condensation of benzamidine on diethyl 5,9‐dihydroxy‐7H‐benzo[a]cycloheptene‐6,8‐dicarboxylate, after opening and then closure of the seven membered ring. 相似文献
63.
The stereoselective synthesis of 5,5-spiroacetals by Rh(II)-catalysed double C–H insertion of methylene acetals bearing two diazo ester substituents is described. The diastereoselectivity of this bidirectional approach can be tuned through appropriate choice of catalyst, and chiral catalysts lead to products with up to 89% ee. The diastereoselectivity of the first cyclisation suggests that the second cyclisation proceeds via a non-concerted pathway. 相似文献
64.
Iminosugar‐Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels
下载免费PDF全文
![点击此处可从《Chemistry (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Mathieu L. Lepage Jérémy P. Schneider Dr. Anne Bodlenner Alessandra Meli Prof. Francesco De Riccardis Dr. Marjorie Schmitt Prof. Céline Tarnus Dr. Nha‐Thi Nguyen‐Huynh Dr. Yannis‐Nicolas Francois Dr. Emmanuelle Leize‐Wagner Dr. Catherine Birck Alexandra Cousido‐Siah Dr. Alberto Podjarny Prof. Irene Izzo Prof. Philippe Compain 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(15):5151-5155
A series of cyclopeptoid‐based iminosugar clusters has been evaluated to finely probe the ligand content‐dependent increase in α‐mannosidase inhibition. This study led to the largest binding enhancement ever reported for an enzyme inhibitor (up to 4700‐fold on a valency‐corrected basis), which represents a substantial advance over the multivalent glycosidase inhibitors previously reported. Electron microscopy imaging and analytical data support, for the best multivalent effects, the formation of a strong chelate complex in which two mannosidase molecules are cross‐linked by one inhibitor. 相似文献
65.
Julien Sarrazin Anne Claire Lepage Xavier Begaud 《Applied Physics A: Materials Science & Processing》2012,109(4):1075-1080
A dual-band Artificial Magnetic Conductor (AMC) is presented in this paper. The proposed metasurface is based on a spiral geometry in which an additional resonance has been introduced thanks to a physical understanding of the structure??s behavior. The design is compact and the two frequency bands can be adjusted independently. Furthermore, an analytical model is developed, which can predict both the frequencies at which the metasurface reflects incident waves in-phase. 相似文献
66.
Dr. Mathieu L. Lepage Dr. Jérémy P. Schneider Dr. Anne Bodlenner Dr. André Mitschler Dr. Alessandra Meli Prof. Irene Izzo Dr. H. Ariel Alvarez Dr. Alberto Podjarny Prof. Philippe Compain 《Angewandte Chemie (International ed. in English)》2018,57(27):8002-8006
Multivalent design of glycosidase inhibitors is a promising strategy for the treatment of diseases involving enzymatic hydrolysis of glycosidic bonds in carbohydrates. An essential prerequisite for successful applications is the atomic‐level understanding of how outstanding binding enhancement occurs with multivalent inhibitors. Herein we report the first high‐resolution crystal structures of the Jack bean α‐mannosidase (JBα‐man) in apo and inhibited states. The three‐dimensional structure of JBα‐man in complex with the multimeric cyclopeptoid‐based inhibitor displaying the largest binding enhancements reported so far provides decisive insight into the molecular mechanisms underlying multivalent effects in glycosidase inhibition. 相似文献
67.
An Artificial Lithium Protective Layer that Enables the Use of Acetonitrile‐Based Electrolytes in Lithium Metal Batteries
下载免费PDF全文
![点击此处可从《Angewandte Chemie (International ed. in English)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Ngoc Duc Trinh Dr. David Lepage Dr. David Aymé‐Perrot Prof. Antonella Badia Prof. Mickael Dollé Prof. Dominic Rochefort 《Angewandte Chemie (International ed. in English)》2018,57(18):5072-5075
The resurgence of the lithium metal battery requires innovations in technology, including the use of non‐conventional liquid electrolytes. The inherent electrochemical potential of lithium metal (?3.04 V vs. SHE) inevitably limits its use in many solvents, such as acetonitrile, which could provide electrolytes with increased conductivity. The aim of this work is to produce an artificial passivation layer at the lithium metal/electrolyte interface that is electrochemically stable in acetonitrile‐based electrolytes. To produce such a stable interface, the lithium metal was immersed in fluoroethylene carbonate (FEC) to generate a passivation layer via the spontaneous decomposition of the solvent. With this passivation layer, the chemical stability of lithium metal is shown for the first time in 1 m LiPF6 in acetonitrile. 相似文献
68.
Paul A. D'Agostino Claude L. Chenier James R. Hancock Carmela R. Jackson Lepage 《Rapid communications in mass spectrometry : RCM》2007,21(4):543-549
Desorption electrospray ionisation mass spectrometry (DESI‐MS) was recently reported for the direct analysis of sample media without the need for additional sample handling. During the present study, direct analysis of solid‐phase microextraction (SPME) fibers by DESI‐MS/MS was evaluated with indoor office media that might be collected during a forensic investigation, including wall surfaces, office fabrics, paper products and Dacron swabs used for liquid sampling. Media spiked at the µg/g level with purified chemical warfare agents and a complex munitions grade sample of tabun, to simulate the quality of chemical warfare agent that might be used for terrorist purposes, were successfully analysed by DESI‐MS/MS. Sulfur mustard, a compound that has not been successfully analysed by electrospray mass spectrometry in the past, was also sampled using a SPME fiber and analysed for the first time by DESI‐MS/MS. Finally, the overall analytical approach involving SPME headspace sampling and DESI‐MS analysis was evaluated during a scenario‐based training live agent exercise. A sarin sample collected by the military was analysed and confirmed by DESI‐MS in a mobile laboratory under realistic field conditions. Copyright © 2007 Crown in the right of Canada. Published by John Wiley & Sons, Ltd. 相似文献
69.
70.