Polarographic Catalytic Wave of Lysozyme

Lysozyme(LE)isatypicalproteinwithwell-knownstrUcture.Itcontainsfourdisulfidebonds,andthreeofthemarewraPpedinsideLEmolecule.Thedisulfidebondbetweencys6andcysl27isexposedexternallyinthehydrophilicregi0n.ItwasfoundthatLEyieldedapolarograPhicwaveinO.2mollLNaAc~HAc(pH4.7)buffersolution.Therewereareductionwave(IP,c)andanoxidationwave(IP,a)inthecyclicvoltanunogram.ThepeakcurrentratiobetweenIP,aandIP,cwasl:l.ThepeakpotentialEP,cofthereductionwavewas-().53V(vs,SCE),andtheEP,aoftheoxidatio…     

1R,3S-1,2,2-三甲基-1,3-环戊二胺为配体的铂髤配合物的合成、表征和抗肿瘤活性

本文合成了9种含有由天然D( )鄄樟脑衍生的1R,3S鄄1,2,2鄄三甲基鄄1,3鄄环戊二胺(A)为配体的铂髤配合物[Pt髤AX]{其中,X=(CH2)3C(COO-)2(1,1鄄环丁烷二羧酸根),2CH3OCH2COO-,2CH3CH2OCH2COO-,2CH3(CH2)3OCH2COO-,[OCH(CH3)COO]2-(乳酸根),(OCH2COO)2-(乙醇酸根),2CH3OCH2CH2OCH2COO-,2CH3CH2OCH2CH2OCH2COO-和2CH3(CH2)3OCH2CH2OCH2COO-}。通过元素分析、热重分析、红外光谱、1H核磁共振谱和电喷雾质谱等对配合物进行了表征。体外生物活性测试表明,部分配合物对A549人肺癌细胞和HCT鄄116人结肠癌细胞具有较强的抗肿瘤活性。     

Ni(OH)2纳米管的制备、表征及电化学性能

以多孔氧化铝为模板, 在不同溶液浓度下, 用化学沉积法制备了氢氧化镍纳米管. 采用XRD, SEM, TEM和HRTEM等手段, 对产物的物相、表面形貌及微结构进行了表征. 结果表明所得产物是高纯度的氢氧化镍纳米管, 外径约为180～220 nm, 管壁厚20～30 nm. 将所制备的氢氧化镍纳米管制成电极, 其电化学性能测试表明, Ni(OH)₂纳米管的中空结构特点, 能够有效地提高镍电极的充电效率、放电比容量、高倍率及高温放电性能. 机理分析表明中空结构的Ni(OH)₂纳米管对于提高碱性二次电池的综合性能有着极为重要的意义.     

Selective Synthesis of [2＋2] Macrocyclic Schiff Bases from Chiral 1,4-Diamines

[2＋2] macrocyclic Schiff bases of three kinds have been synthesized from chiral 1,4-diamines by use of different methods. Macrocyclic Schiff bases 1a-1c have been selectively obtained based on a non-templated dilution method from chiral 1,4-diamines a-c and dialdehyde DA1, whereas macrocycles 2a-2c have been selectively produced from reaction of diamines a-c and dialdehyde DA2 in the presence of boric acid as templates. Macrocyclic Schiff bases 3a-3c have been afforded in high selectivity from diamines a-c and dialdehyde DA3 by means of sodium-template. All the titled compounds have been confirmed by ^1H NMR and ESI-MS analyses.     

烷氧基酸为离去基团的铂(Ⅱ)配合物的体外活性研究

合成了5个以直链和带支链烷氧基乙酸为载体配基的顺铂类配合物,通过红外光谱、核磁共振氢谱和质谱对配合物进行了表征,并测试了化合物对肺腺癌SPC-A1和胃腺癌BGC823的体外抗肿瘤活性。生物活性测试结果表明,配合物的活性与离去基团有很大关系。配合物4(顺-二(异丙氧基乙酸根)·[(1R,2R)-1,2-反式环己二胺]合铂(Ⅱ))在2个细胞系中均显示最高的体外抗肿瘤活性,甚至超过顺铂。     

化学-生物法制备D-精氨酸和L-瓜氨酸

在水溶液中以水杨醛为催化剂,L-精氨酸可以快速消旋为DL-精氨酸．后以DL-精氨酸为底物,利用粪链球菌（Streptococcus faecalis）精氨酸脱亚胺酶对L-精氨酸的专一脱亚胺作用,同时制备D精氨酸和L-瓜氨酸,分别以92．3％,94．2％的产率获得光学纯的D-精氨酸和L-瓜氨酸．     

中子非弹性散射对Bi12GeO20和Bi12SiO20旋声性的研究

通过用中子非弹性散射测量旋声晶体高对称方向的横声学支声子色散曲线的劈裂,从三个方面研究了同构异质晶体Bi₁₂GeO₂₀和Bi₁₂SiO₂₀的旋声特性。值得注意的是,沿〈111〉方向传播的左旋、右旋圆偏振声子具有不同的衰减。其中传播速度快的圆偏振声子衰减较大,该结论为这两种晶体所证实,这是在晶体旋声性研究中首次观察到的现象。实验还直接确定了衰减较大的这支声子的寿命约为2×10^-11S。 关键词：     

First way of enantioselective synthesis of moxifloxacin intermediate

A new method of enantioselective synthesis of(S,S)-2,8-diazobicyclo [4.3.0] nonane was found by using(R)-2-amino-2phenyl-ethanol as chiral induction reagent.The entire synthetic process included 8 steps which were easy to operate with high yield.The purification method was only simple recrystallization or even used directly in the next step without further purification.The total yield was 29%.     

用UV-Vis法研究聚乙烯醇水溶液的透明度

用紫外可见分光光度计(UV-vis)测试了聚乙烯醇(PVA)水溶液和盐溶液的透明度,研究了PVA醇解度、电解质和温度对PVA溶液透明度的影响.实验结果表明,UV-Vis法是一种简便可行的测定PVA溶液透明度的方法.     

First-Principle Calculations for Thermodynamic Properties of LiBC Under High Temperature and High Pressure

The thermodynamic properties of LiBC are investigated by using the full-potential linearlzed muffin-tin orbital method （FP-LMTO） within the frame of density functional theory （DFT） and using the quasi-harmonic Debye model. The dependencies of the normalized lattice parameters a/a0 and c/c0, the ratio （c/a）/2, the normalized primitive volume V/V0 on pressure and temperature are successfully obtained. It is found that the interlayer covalent interactions （Li-B bonds or Li-C bonds） are more sensitive to temperature and pressure than intralayer ones （B-C bonds）, as gives rise to the extreme lattice anisotropy in the bulk hop LiBC.