Numerical analysis of finite amplitude motion of waves and a moored floating body under severe storm conditions

The motion of a moored floating body under the action of wave forces, which is influenced by fluid forces, shape of the floating body and mooring forces, should be analysed as a complex coupled motion system. Especially under severe storm conditions or resonant motion of the floating body it is necessary to consider finite amplitude motions of the waves, the floating body and the mooring lines as well as non-linear interactions of these finite amplitude motions. The problem of a floating body has been studied on the basis of linear wave theory by many researchers. However, the finite amplitude motion under a correlated motion system has rarely been taken into account. This paper presents a numerical method for calculating the finite amplitude motion when a floating body is moored by non-linear mooring lines such as chains and cables under severe storm conditions.     

On the entropy of fusion

The asymptotic value of the melting entropy, i.e. ΔS_f = R ln 2 for vanishing relative change of volume on melting, can be derived from the vibrational entropy due to vibrating dislocations, which are introduced into a material on melting.     

Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitor

Intravascular clot formation is an important factor in a number of cardiovascular diseases. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), which is a key enzyme in coagulation cascade responsible for the generation of thrombin by limited proteolysis of its zymogen, prothrombin. We have investigated 1-arylsulfonyl-3-piperazinone derivatives, containing a 4-(piperidino)pyridine group in place of guanidino and/or amidino groups, and discovered compound M55113 (30a: 4-[(6-Chloro-2-naphthalenyl)sulfonyl]-1-[[1-(4-pyridinyl)-4-piperidinyl]methyl]piperazinone), as a potent inhibitor of FXa (IC50=0.06 microM) with high selectivity for FXa over trypsin and thrombin.     

Solvent free synthesis of polyaniline-clay nanocomposites from mechanochemically intercalated anilinium fluoride

Nanocomposites consisting of conducting polyaniline and clay minerals were successfully synthesized from mechanochemically intercalated anilinium fluoride; the nanocomposites prepared by the mechanochemical intercalation method contained much more polyaniline in the clay layers than those prepared by a conventional solution method.     

Effect of 1,10-phenanthroline on the extraction and separation of lithium(I), sodium(I) and potassium(I) with thenoyltrifluoroacetone

The extraction of Li⁺ with thenoyltrifluoroacetone (Htta) in the presence of 1,10-phenanthroline (phen) has been studied in various organic solvents. The remarkable enhancement of the extraction of Li⁺, that is a synergistic effect, was observed by the addition of phen, and the high extractability of Li⁺ was attained in toluene, benzene, chlorobenzene and o-dichlorobenzene. The extraction equilibrium of Li⁺, Na⁺ and K⁺ (denoted as M⁺) in the presence or absence of phen in chlorobenzene and the adduct formation reaction in the organic phase were studied in detail. The adduct of Li⁺ was Li(tta)(phen) in the wide concentration range of phen in the organic phase, while in Na⁺ and K⁺ M(tta)(phen)₂ also exists in the high concentration region. The maximum value of the separation factor between Li⁺ and Na⁺ was observed in the present system and was larger than that in the Htta-trioctylphosphine oxide (TOPO)-benzene system reported previously.