Axially Symmetric Solution of the Weyl–Cartan Theory of Gravity and the Problem of the Rotation Curves of Galaxies

Russian Physics Journal -     

Glycation sites of human plasma proteins are affected to different extents by hyperglycemic conditions in type 2 diabetes mellitus

Glucose can modify proteins in human blood, forming early glycation products (e.g., Amadori compounds), which can slowly degrade to advanced glycation endproducts (AGEs). AGEs contribute significantly to complications of diabetes mellitus and, thus, represent markers of advanced disease stages. They are, however, currently unsuitable for early diagnosis and therapeutic monitoring. Here, we report sensitive strategies to identify and relatively quantify protein glycation sites in human plasma samples obtained from type 2 diabetes mellitus (T2DM) patients and age-matched nondiabetic individuals using a bottom-up approach. Specifically, Amadori peptides were enriched from tryptic digests by boronic acid affinity chromatography, separated by reversed-phase chromatography, and analyzed on-line by high-resolution mass spectrometry. Among the 52 Amadori peptides studied here were 20 peptides resembling 19 glycation sites in six human proteins detected at statistically significantly higher levels in T2DM than in the normoglycemic controls. Four positions appeared to be unique for T2DM within the detection limit. All 19 glycation sites represent promising new biomarker candidates for early diagnosis of T2DM and adequate therapeutic control, as they may indicate early metabolic changes preceding T2DM. Graphical Abstract

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The Use of Galvanic Displacement for Synthesizing Pt/Carbide (Mo2C,ZrC, NbC) Catalysts Highly Active in the Hydrogen Evolution Reaction

Russian Journal of Electrochemistry - The composite materials involving platinum nanoparticles on the surface of carbides of Mo, Zr, and Nb are synthesized by the currentless redox reaction between...     

Detailed kinetic mechanism of the multistep oxidation and combustion of isopentane and isohexane

A detailed kinetic mechanism was developed for the oxidation and combustion of isopentane (2-methylbutane) and isohexane (2-methylpentane), which describes both high-temperature reactions and a multistep process in the region of low temperatures. These hydrocarbons were chosen because they, together with isobutane, are the first members in the homologous series of isomerized alkanes and a higher member of this series—isooctane (2,2,4-trimethylpentane)—exhibited multistep self-ignition in experiments; in this case, the above isomers can be important intermediate products. The process of the multistep self-ignition of the above hydrocarbons under specific conditions occurs in three sequential steps (in the form of cold and blue flames and hot explosion) characteristic of normal alkanes. The calculations of self-ignition and flame propagation were performed by the developed mechanism; the results of the calculations were compared with the experimental data and their satisfactory qualitative and quantitative agreement was obtained.     

Thermal and structural characterization of bitumen by modulated differential scanning calorimetry

Journal of Thermal Analysis and Calorimetry - This paper presents the results of investigation of model bitumens, prepared by mixing of individual fractions of bitumen (saturates, aromatics, waxes,...     

Precipitation of Energetic Electrons from the Earth’s Radiation Belt Stimulated by High-Power HF Radio Waves for Modification of the Midlatitude Ionosphere

Radiophysics and Quantum Electronics - Based on the results of the experiments performed in 2005–2010 within the framework of the Sura—DEMETER program, we analyze the features of the...     

Artificial Precipitation of Energetic Electrons in a Magnetically Conjugate Region of the Ionosphere Relative to the Sura Facility

Radiophysics and Quantum Electronics - We analyze the features of energetic electron precipitation (with the maximum energy E ≥ 150 keV) from the Earth’s radiation belt into a...     

Cooling of silver bullet laser diode submodules

The feasibility of using microfinned microchannel structures in copper heat exchangers designed for cooling semiconductor modules that pump powerful solid-state lasers is considered. Efficient heat exchangers are developed, and pumping modules with a continuous radiation power of 760 W are produced.