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排序方式: 共有170条查询结果,搜索用时 31 毫秒
31.
Friedemann Leibfritz 《PAMM》2005,5(1):751-752
We consider the solution of the static output feedback (SOF) ℋ︁∞ control design problem. In particular, we solve the corresponding non–convex and nonlinear semidefinite program (NSDP), the so–called ℋ︁∞–NSDP, by a suitable optimization solver. Finally, we demonstrate the behavior of the solver on the COMPleibbenchmark collection. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
32.
Connor S. MacNeil Lauren N. Mendelsohn Hongyu Zhong Tyler P. Pabst Prof. Paul J. Chirik 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(23):8997-9001
Intermediates relevant to cobalt-catalyzed alkene hydroformylation have been isolated and evaluated in fundamental organometallic transformations relevant to aldehyde formation. The 18-electron (R,R)-(iPrDuPhos)Co(CO)2H has been structurally characterized, and it promotes exclusive hydrogenation of styrene in the presence of 50 bar of H2/CO gas (1:1) at 100 °C. Deuterium-labeling studies established reversible 2,1-insertion of styrene into the Co−D bond of (R,R)-(iPrDuPhos)Co(CO)2D. Whereas rapid β-hydrogen elimination from cobalt alkyls occurred under an N2 atmosphere, alkylation of (R,R)-(iPrDuPhos)Co(CO)2Cl in the presence of CO enabled the interception of (R,R)-(iPrDuPhos)Co(CO)2C(O)CH2CH2Ph, which upon hydrogenolysis under 4 atm H2 produced the corresponding aldehyde and cobalt hydride, demonstrating the feasibility of elementary steps in hydroformylation. Both the hydride and chloride derivatives, (X=H−, Cl−), underwent exchange with free 13CO. Under reduced pressure, (R,R)-(iPrDuPhos)Co(CO)2Cl underwent CO dissociation to form (R,R)-(iPrDuPhos)Co(CO)Cl. 相似文献
33.
S. Mittag D. Pabst L.B. Pikelner W. Pilz R. Tschammer A. Meister D. Seeliger K. Seidel 《Nuclear Physics A》1985,435(1):97-109
Transmission spectra were measured with the time-of-flight technique at the Dubna pulsed reactor for samples of metallic U, UO2, U3O8, and UO3 enriched in 235U, and were compared in the regions of nine low-energy resonances to observe chemically induced shifts. After elimination of contributions caused by different Doppler broadenings, the shifts are interpreted as changes of the mean-square charge radius for nuclei capturing neutrons. The 〈r2〉 of the compound-nucleus states show on average a weak diminution as compared with the ground-state value. 相似文献
34.
35.
Hugo B. C. Kleikamp Yue Mei Lin Duncan G. G. McMillan Jeanine S. Geelhoed Suzanne N. H. Naus-Wiezer Peter van Baarlen Chinmoy Saha Rogier Louwen Dimitry Y. Sorokin Mark C. M. van Loosdrecht Martin Pabst 《Chemical science》2020,11(11):3074
Nonulosonic acids, commonly referred to as sialic acids, are a highly important group of nine-carbon sugars common to all domains of life. They all share biosynthetic and structural features, but otherwise display a remarkable chemical diversity. In humans, sialic acids cover all cells which makes them important for processes such as cellular protection, immunity and brain development. On the other hand, sialic acids and other nonulosonic acids have been associated with pathological processes including cancer and viral infections. In prokaryotes, nonulosonic acids are commonly associated with pathogens, which developed through molecular mimicry a strategy to circumvent the host''s immune response. However, the remarkably large chemical diversity of prokaryotic nonulosonic acids challenges their discovery, and research on molecular characteristics essential for medical applications are often not feasible. Here, we demonstrate a novel, universal large-scale discovery approach that tackles the unmapped diversity of prokaryotic nonulosonic acids. Thereby, we utilize selective chemical labelling combined with a newly established mass spectrometric all-ion-reaction scanning approach to identify nonulosonic acids and other ulosonic acid-like sugars. In doing so, we provide a first molecular-level comparative study on the frequency and diversity across different phyla. We not only illustrate their surprisingly wide-spread occurrence in non-pathogenic species, but also provide evidence of potential higher carbon variants. Many biomedical studies rely on synthetic routes for sialic acids, which are highly demanding and often of low product yields. Our approach enables large-scale exploration for alternative sources of these highly important compounds.A novel large-scale survey approach for microbial nonulosonic acids (sialic acids) including a first molecular level comparative study is presented. 相似文献
36.
Jäger R Schmidt F Schilling B Brickmann J 《Journal of computer-aided molecular design》2000,14(7):631-646
A method for the localization, the quantification, and the analysis of hydrophobicity of a molecule or a molecular fragment is presented. It is shown that the free energy of solvation for a molecule or the transfer free energy from one solvent to another can be represented by a surface integral of a scalar quantity, the molecular free energy surface density (MolFESD), over the solvent accessible surface of that molecule. This MolFESD concept is based on a model approach where the solvent molecules are considered to be small in comparison to the solute molecule, and the solvent can be represented by a continuous medium with a given dielectric constant. The transfer energy surface density for a 1-octanol/water system is empirically determined employing a set of atomic increment contributions and distance dependent membership functions measuring the contribution of the increments to the surface value of the MolFESD. The MolFESD concept can be well used for the quantification of the purely hydrophobic contribution to the binding constants of molecule-receptor complexes. This is demonstrated with the sweeteners sucrose and sucralose and various halogen derivatives. Therein the relative sweetness, which is assumed to be proportional to the binding constant, nicely correlates to the surface integral over the positive, hydrophobic part of the MolFESD, indicating that the sweetness receptor can be characterized by a highly flexible hydrophobic pocket instead of a localized binding site. 相似文献
37.
Bohne C Faulhaber K Giese B Häfner A Hofmann A Ihmels H Köhler AK Perä S Schneider F Sheepwash MA 《Journal of the American Chemical Society》2005,127(1):76-85
Mechanistic investigations of the photoinduced DNA damage by acridizinium salts (4a-azonia-anthracene derivatives) are presented. Irradiation of 9-bromoacridizinium in the presence of defined double- and single-stranded DNA oligomers under aerobic conditions leads to both frank strand breaks and alkali-labile sites as determined by polyacrylamide gel electrophoresis (PAGE). The extent of the DNA damage increases significantly in D(2)O and occurs selectively at guanosine residues. These observations reveal the formation of singlet oxygen ((1)O(2)) as reactive species, which oxidizes the DNA bases, above all the guanine bases. Further evidence for (1)O(2) formation was obtained from laser-flash spectroscopic investigations, which show intersystem crossing (S(1) to T(1)) of the excited states of the parent acridizinium and of the 9-bromo- and 9-amino-substituted derivatives. The resulting triplet state is efficiently quenched by oxygen (k(q) > 10(9) s(-)(1)M(-)(1)) to yield (1)O(2). Under anaerobic conditions, no significant alkali-labile lesions are observed, but frank strand breaks are induced; however, to lesser extent than under aerobic conditions. The DNA damage is suppressed in the presence of a radical scavenger, namely t-BuOH, and hydroxyl radicals are shown to be the reactive intermediates by trapping experiments with terephthalic acid. Moreover, the intercalated acridizinium molecules are not involved in the DNA damage reactions. The intercalated acridizinium salt leads to a primary PET reaction with the DNA bases; however, a fast BET transfer is proposed that regains the dye and the DNA, so that the excited intercalated dye does not contribute significantly to the overall DNA damage. 相似文献
38.
Rudolf Friedemann Kai Tittmann Ralph Golbik Gerhard Hübner 《International journal of quantum chemistry》2004,99(2):109-114
The diphosphate ester (ThDP) of thiamin (vitamin B1) is an important cofactor of enzymes within the carbohydrate metabolism. From experiments of site‐specific variants and nuclear magnetic resonance (NMR) studies, it is known that the protonation of the N1′ atom is a significant step in the coenzyme activation by the enzymatic environment. Therefore, we have performed density functional theory (DFT) calculations on the B3LYP/6‐31G* level of N1′H and N1′CH3 thiamin as model systems to study the protonation and methylation effect on the structure and the electronic properties of the 4′‐amino group. The relaxed rotational barriers related to the C4′‐4′N bond are correlated with findings of 1H NMR studies and proton/deuterium exchange experiments. Moreover, the effect of N1′ protonation was studied in more detail on the hydroxyethyl‐thiamin carbanion (HETh?), a key intermediate during catalysis of some ThDP‐dependent enzymes. The relaxed rotational barriers related to the C2? C2α bond and the reaction coordinates of the proton transfer 4′N? H→C2α of HETh? and N1′H‐HETh? show that they are significantly determined by the protonation at N1′ of HETh?. The influence of the apoenzyme environment on the active coenzyme conformation is modeled in a very simple way. The characteristic torsion angles ΦT and ΦP are considered to be restricted in terms of their values in the corresponding enzyme as well as free optimization parameters. Frequency calculations were performed to characterize the minima and transition state structures, respectively. The applicability of the DFT method was checked by comparing calculations on the MP2‐HF‐SCF/6‐31G* level. © 2004 Wiley Periodicals, Inc. Int J Quantum Chem, 2004 相似文献
39.
Simone L. Pabst 《代数通讯》2013,41(11):5053-5065
In this paper we generalize the notion of Fountain-Gould order to the context of associative pairs. We give theorems about the existence and uniqueness of the left quotient pair and we obtain a Goldie-like haracterization which describes left orders in semiprime pairs coinciding with their socle. 相似文献
40.
Friedemann Kemm 《国际流体数值方法杂志》2011,67(4):404-440
This paper gives a comparative study of TVD‐limiters for standard explicit Finite Volume schemes. In contrast to older studies, it includes also unsymmetrical limiter functions that depend on the local CFL‐number. We classify the limiters and show how to extend these families of limiters. We introduce a new member of the Superbee family, which is adapted to Roe's linear third‐order scheme. Based on an idea by Serna and Marquina, new smooth limiters are introduced, which turn the van Leer and van Albada limiters into complete classes of limiters. The comparison of the limiters is done with some standard test cases. The results clarify the influence of the chosen limiter on the quality of the numerical results. Compared with ENO or WENO schemes, they also show the high resolution, which can be obtained by a CFL‐number‐dependent limiter when the grid is not highly refined. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献