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31.
32.
Efficient method for visualization and isolation of proteins resolved in polyacrylamide gels 总被引:3,自引:0,他引:3
R T Francis J R Davie M Sayre E Rocha F Ziemer G Riedel 《Journal of chromatography. A》1984,298(1):115-121
Polyacrylamide gel electrophoresis is a popular method used to purify proteins for reconstitution experiments, amino acid composition and sequence determinations. In this report we describe methods that will be of general use in the isolation and characterization of proteins and the benefits of substituting boric acid for glycine in the electrophoresis tray buffers. We also describe how proteins resolved in a variety of gel systems (including those containing sodium dodecyl sulfate) may be rapidly visualized with 8-anilino-1-naphthalene sulfonic acid and efficiently transferred to a second gel for two-dimensional gel analysis, or isolated by electroelution for subsequent characterization. 相似文献
33.
Francis Pochat 《Tetrahedron letters》1981,22(37):3595-3596
Ar-C(CN)=NN=C(CN)-Ar and Ar-C(CN)=NNHCO-Ar′, easily prepared from the bromoderivatives Ar-CBr(SEt)-CN, afford in good yields, by heating in a basic medium, 3,6-diaryl-5 hydroxy-1,2,4-triazines. 相似文献
34.
A new protecting group has been developed for the exocyclic amino groups of nucleosides that occur in DNA. 3-Phenyl-[{N-(2-trimethylsilyl-ethoxycarbonyl)-2-amino}]-propanoic acid used as the protective agent. 相似文献
35.
Jockusch RA Kroemer RT Talbot FO Snoek LC Carçabal P Simons JP Havenith M Bakker JM Compagnon I Meijer G von Helden G 《Journal of the American Chemical Society》2004,126(18):5709-5714
The beta(1-->4) glycosidic linkage found in lactose is a prevalent structural motif in many carbohydrates and glycoconjugates. Using UV and IR ion-dip spectroscopies to probe benzyl lactoside isolated in the gas phase, we find that the disaccharide unit adopts only a single, rigid structure. Its fully resolved infrared ion-dip spectrum is in excellent agreement with that of the global minimum structure computed ab initio. This has glycosidic torsion angles of phi(H) (H1-C1-O-C4') approximately 180 degrees and psi(H) (C1-O-C4'-H4') approximately 0 degrees which correspond to a rotation of approximately 150 degrees about the glycosidic bond compared to the accepted solution-phase conformation. We discuss the biological implications of this discovery and the generality of the strategies employed in making it. 相似文献
36.
The reaction of PhSeCl and N-PSP with homogeranic acid () or homoneric acid () affords butanolides in a stereospecific way. Despite the large number of cyclic cases studied in the literature such acyclic systems were remained largely unexplored. PhSe+ was unable to realize polycyclization. 相似文献
37.
Kinetics of poly(ethylene terephthalate) glycolysis by diethylene glycol. I. Evolution of liquid and solid phases 总被引:1,自引:0,他引:1
The kinetics of uncatalysed glycolysis, at 220 °C, of poly(ethylene terephthalate) (PET) by diethylene glycol (DEG) in high excess has been studied. An experimental device allowing good separation, at reaction temperature, of the solid and liquid phases was set up.The results suggest that PET is initially depolymerized in the slightly swollen solid phase, by glycolysis of the amorphous interlamellar chains. This mechanism continues until a solid phase of highly crystallized polyester is obtained.The internal tensions engendered by this chemical modification cause cracks, delamination and mechanical disintegration of the polymer. The transfer towards the liquid phase is then strongly accelerated and the solvolysis of the depolymerization products continues in the liquid phase, up to equilibrium. 相似文献
38.
Mieszawska AJ Jalilian R Sumanasekera GU Zamborini FP 《Journal of the American Chemical Society》2005,127(31):10822-10823
This contribution describes the synthesis of gold nanorod (Au NR)/single-wall carbon nanotube (SWCNT) heterojunctions assembled directly on Si/SiOx substrates. SWCNTs are attached to amine-functionalized Si/SiOx substrates, and Au monolayer-protected clusters (MPCs) are adsorbed to the surface of SWCNTs through hydrophobic interactions. Seed-mediated reduction of HAuCl4 with ascorbic acid in the presence of cetyltrimethylammonium bromide (CTAB) onto the Au MPCs leads to the growth of larger Au nanostructures directly on the SWCNTs. Au NRs account for 19% of the nanostructures, some of which are attached directly to the sidewall and some at the ends of the SWCNTs. Raman spectroscopic measurements of SWCNTs before and after growth of the Au nanostructures reveal that the presence of Au leads to an approximately 50-fold enhancement of the Raman scattering signal. Combining 1D nanostructures of different materials (Au and carbon in this example) is of fundamental interest and may find use in nanoelectronics, chemical sensing, electrochemical, and spectroscopy applications. 相似文献
39.
Lithium diisopropylamide reacts with 2-fluoropyridine at low temperature: regioselectivity is excellent and metallation occurs without side reactions such as nucleophilic attack. 2-Fluoro-3-lithiopyridine is formed and with aldehydes it gives the corresponding fluorinated alcohols which are then selectively oxidized. Halogen substitution using amines leads to various 3-oxoalkyl- or 3-aroyl-2-aminopyridines. 相似文献
40.
The kinetics of poly(ethylene terephthalate) (PET) glycolysis by diethylene glycol (DEG), dipropylene glycol (DPG), glycerol (Gly) and mixtures of these glycols have been studied with two experimental procedures: uncatalysed at 220 °C and catalysed at 190 °C. An experimental device was set up allowing the isothermal kinetics to be monitored. A precise initial reaction time was obtained by separately warming the glycol and the polyester at the temperature of reaction before mixing them.The reactivity order of different glycols varies according to the conditions of temperature and catalysis. Schematically, the global reactivity does depend not only on the chemical reactivity of the glycol but also on its physico-chemical properties: ability to solvate the solid polyesters and polarity of the reaction mixture. Attempts to find synergic effects failed for almost all mixtures, except the mixture DPG + Gly in which the PET is digested more quickly than in pure DPG or Gly. 相似文献