Using mathematical programming heuristics in a multicriteria network flow context

In this paper, we propose a local search procedure to test the robustness of a specific ‘satisfying point’ neighbourhood. It consists of the following steps: (1) build an indifference area around the satisfying point in the criteria space by using thresholds (this takes into account the possible uncertainty, vagueness and/or inaccuracy of data); (2) find some points in the satisfying point neighbourhood and the corresponding solutions in the decision variables space; (3) test the quality of these solutions from the point of view of user preference. The indifference area is defined by adding constraints to the network model. This approach, which allows us to verify the adequacy of the model, has been applied to a set of multicriteria network flow problems. A heuristic method, based on Lagrangian duality and subgradient techniques, exploits the combinatorial structure of network flow problems in order to find certain feasible points.     

Dead Ends and Detours En Route to Total Syntheses of the 1990s A list of abbreviations can be found at the end of the article

From the very beginning organic chemistry and total synthesis have been intimately joined. In fact, one of the first things that freshmen in organic chemistry learn is how to join two molecules together to obtain a more complex one. Of course they still have a long way to go to become fully mature synthetic chemists, but they must have the primary instinct to build molecules, as synthesis is the essence of organic chemistry. With the different points of view that actually coexist in the chemical community about the maturity of the science (art, or both) of organic synthesis, it is clear that nowadays we know how to make almost all of the most complex molecules ever isolated. The primary question is how easy is it to accomplish? For the readers of papers describing the total synthesis of either simple or complex molecules, it appears that the routes followed are, most of the time, smooth and free of troubles. The synthetic scheme written on paper is, apparently, done in the laboratory with few, if any, modifications and these, essentially, seem to be based on finding the optimal experimental conditions to effect the desired reaction. Failures in the planned synthetic scheme to achieve the goal, detours imposed by unexpected reactivity, or the absence of reactivity are almost never discussed, since they may diminish the value of the work reported. This review attempts to look at total synthesis from a different side; it will focus on troubles found during the synthetic work that cause detours from the original synthetic plan, or on the dead ends that eventually may force redesign. From there, the evolution from the original route to the final successful one that achieves the synthetic target will be presented. The syntheses discussed in this paper have been selected because they contain explicit information about the failures of the original synthetic plan, together with the evolution of the final route to the target molecule. Therefore, they contain a lot of useful negative information that may otherwise be lost.     

Crystallization of KNbO3 in a B2O3 glass network

The ferroelectric material potassium niobate (KNbO₃) has a large number of exceptional electronic and optical properties with important technological applications. Due to the high preparation difficulties and costs of the single crystals, a considerable interest in the preparation of glass-ceramics with the KNbO₃ crystal phase exists. In this work we present the preparation of a glass, with the composition 40B₂O₃–40K₂O–20Nb₂O₅ (% mole), through the melt-quenching method and glass-ceramics obtained by controlled heat-treatments. The samples structure was analyzed using X-ray power diffraction (XRD), scanning electron microscopy (SEM) and Raman spectroscopy. KNbO₃ crystals were detected in the glass sample treated at 500 °C. For treatments at temperatures above 500 °C, other niobium-based crystal phases are present. The behavior of the heat-treatment temperature parameter, in the glass and glass ceramic structure, is discussed.