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91.
Abdoullah Bimoussa Ali Oubella Yassine Laamari Mourad Fawzi Mouhi Eddine Hachim My Youssef Ait Itto Hamid Morjani El Mostafa Ketatni Olivier Mentre Aziz Auhmani 《Journal of heterocyclic chemistry》2021,58(12):2334-2347
A new 1,2,3-triazole sesquiterpenic named (4aR,5aS,7aR,10aR,10bR)-10-benzyl-5,5-dichloro-1,1,4a,7a-tetramethyl-1,2,3,4,4a,5,7a,10,10a,10b decahydrocyclopropa[2′,3′]cyclohepta [1′,2′:3,4]benzo[1,2-d][1,2,3]triazol-7(6H)-one was synthesized by a dipolar cycloaddition 1,3 between benzyl azide and α,β-unsaturated sesquiterpene ketone catalyzed by titanium tetrachloride TiCl4. It was obtained with a good yield and characterized using single-crystal X-ray diffraction technique, infra red (IR) spectroscopy, High Resolution Mass Spectrometry (HRMS), UV-Visible, and 1H and 13C NMR spectroscopies. The optimization by the density functional theory (DFT) method was carried out to study the formation mechanism of the derivative. The selected compounds 1 – 4 exhibited anticancer activities in vitro against namely fibrosarcoma (HT-1080), lung carcinoma (A-549), and breast (MCF-7 and MDA-MB-231 cell lines with IC50 in the range of 10.02–44.71 μM). In addition to using flow cytometry and the apoptosis assay, cell cycle arrest at the S phase (10 μM) and G2/M arrest in (5 and 10 μM) was performed for compound 4 in fibrosarcoma (HT-1080) cancer cells. Results suggested that compound 4 test with good activity against HT-1080 cells with IC50 value from 10.02 μM and induced the apoptotic effect. Theoretical studies were realized to estimate the molecular proprieties that lead to a high potential of cytotoxic effect, which is in agreement with the experimental results. 相似文献
92.
Zhang X Jiang M Fawzi AA Li X Shung KK Puliafito CA Zhang HF Jiao S 《Optics letters》2010,35(23):4018-4020
We investigated the feasibility of simultaneously imaging two distinctive molecular contrasts provided by the absorbed photons in biological tissues with a single light source. The molecular contrasts are based on two physical effects induced by the absorbed photons: photoacoustics (PA) and autofluorescence (AF). In an integrated multimodal imaging system, the PA and AF signals were detected by a high-sensitivity ultrasonic transducer and an avalanche photodetector, respectively. The system was tested by imaging ocular tissue samples, including the retinal pigment epithelium and the ciliary body. The acquired images provided information on the spatial distributions of melanin and lipofuscin in these samples. 相似文献
93.
94.
Al-Allaf Talal A. K. Rashan Luay J. Abu-Surrah Adnan S. Fawzi Riad Steimann Manfred 《Transition Metal Chemistry》1998,23(4):403-406
Treatment of cis-[Pt(dmso)2Cl2] with 2 mol of KBr or KI leads to the formation of the analogous dibromide or diiodide complexes. Treatment of [M(dmso)2Cl2] [M = Pt (cis-) or Pd (trans-)] with AgNO3 (2 mol) in H2O followed by 1mol of potassium oxalate, maleate, cyclobutane dicarboxylate (CBDC), malonate or 2mol of potassium cyclohexane carboxylate or pivalate leads to the formation of the corresponding PtII and PdII carboxylate complexes. The single crystal X-ray structure determination of [Pt(dmso)2(CBDC)] has been discussed and compared with data on other related complexes. The in vitro cytotoxic activity of some of these complexes against eight tumour cell lines has been examined using the MTT-colorimetric assay. 相似文献
95.
96.
Fawzi M. Yaqub 《Algebra Universalis》1990,27(2):289-298
Following A. Abian, we define amolecule of a partially ordered set to be any nonzero elementm with the property that any two nonzero elements less than or equal tom have a nonzero lower bound. In a Boolean algebra an element is a molecule iff it is an atom; however, in an arbitrary distributive lattice the notion of a molecule is too general to permit explicit characterization. In this note we examine the molecules in a coproduct of two distributive lattices and use our results to show that molecules play the same role in Post algebras as atoms do in Boolean algebras.Presented by R. S. Pierce.I would like to thank the referee for helpful comments that resulted in simplifying a number of proofs in this paper. 相似文献
97.
98.
Let P be a finite poset and let L={x
1<...n} be a linear extension of P. A bump in L is an ordered pair (x
i
, x
i+1) where x
ii+1 in P. The bump number of P is the least integer b(P), such that there exists a linear extension of P with b(P) bumps. We call L optimal if the number of bumps of L is b(P). We call L greedy if x
i
j for every j>i, whenever (x
i, x
i+1) is a bump. A poset P is called greedy if every greedy linear extension of P is optimal. Our main result is that in a greedy poset every optimal linear extension is greedy. As a consequence, we prove that every greedy poset of bump number k is the linear sum of k+1 greedy posets, each of bump number zero.This research (Math/1406/31) was supported by the Research Center, College of Science, King Saud University, Riyadh, Saudi Arabia. 相似文献
99.
Katharigatta N. Venugopala Pottathil Shinu Christophe Tratrat Pran Kishore Deb Raquel M. Gleiser Sandeep Chandrashekharappa Deepak Chopra Mahesh Attimarad Anroop B. Nair Nagaraja Sreeharsha Fawzi M. Mahomoodally Michelyne Haroun Mahmoud Kandeel Syed Mohammed Basheeruddin Asdaq Viresh Mohanlall Nizar A. Al-Shari Mohamed A. Morsy 《Molecules (Basel, Switzerland)》2022,27(9)
Alteration of insect growth regulators by the action of inhibitors is becoming an attractive strategy to combat disease-transmitting insects. In the present study, we investigated the larvicidal effect of 1,2,3-triazolyl-pyrimidinone derivatives against the larvae of the mosquito Anopheles arabiensis, a vector of malaria. All compounds demonstrated insecticidal activity against mosquito larvae in a dose-dependent fashion. A preliminary study of the structure–activity relationship indicated that the electron-withdrawing substituent in the para position of the 4-phenyl-pyrimidinone moiety enhanced the molecules’ potency. A docking study of these derivatives revealed favorable binding affinity for the sterol carrier protein-2 receptor, a protein present in the intestine of the mosquito larvae. Being effective insecticides against the malaria-transmitting Anopheles arabiensis, 1,2,3-triazole-based pyrimidinones represent a starting point to develop novel inhibitors of insect growth regulators. 相似文献
100.
Abstract The X-ray structures of the phosphametallacycloalkanes 11 were investigated to understand the anomalous chemical shift behavior of the phosphorus incorporated in the ringsystem. The 31P chemical shifts could not be related to bond angles and to Tolman angles. An electronic contribution to the δP value could be excluded, while the torsional angle effect proved to be the dominant factor. 相似文献