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排序方式: 共有324条查询结果,搜索用时 31 毫秒
101.
Jinghua Shi Oguzhan Alagoz Fatih Safa Erenay Qiang Su 《Annals of Operations Research》2014,221(1):331-356
While chemotherapy is an effective method for treating cancers such as colorectal cancer, its effectiveness may be dampened by the drug resistance and it may have significant side effects due to the destruction of normal cells during the treatment. As a result, there is a need for research on choosing an optimal chemotherapy treatment plan that minimizes the number of cancerous cells while ensuring that the total toxicity is below an allowable limit. In this paper, we summarize the mathematical models applied to the optimal design of the cancer chemotherapy. We first elaborate on a typical optimization model and classify relevant literature with respect to modeling methods: Optimal control model (OCM) and others. We further classify the OCM models with respect to the solution method used. We discuss the limitations of the existing research and provide several directions for further research in optimizing chemotherapy treatment planning. 相似文献
102.
Fatih Özkaynak 《Nonlinear dynamics》2014,78(3):2015-2020
Random number generators are an important tool for cryptographic applications. In cryptographic protocol, randomness is essential properties since inadequate source of randomness can be effect security of whole system. This paper describes requirements of a robust random generator and proposes hybrid architecture to realize these requirements. Security analysis shows that output of proposed generator looks random. Therefore, proposed generator is used for cryptographic solutions. 相似文献
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105.
Ali İhsan Öztürk Fatih Aslan Ökkeş Yılmaz Mehmet Alğın Mustafa Arslan H. İbrahim Mutlu 《Phosphorus, sulfur, and silicon and the related elements》2013,188(5):585-595
Abstract Hexa(4-bromo-2-formyl-phenoxy)cyclotriphosphazene (2) and hexa(4-chloro-2- formyl-phenoxy)cyclotriphosphazene (3) were obtained from the reactions of hexachloro- cyclotriphosphazene (1) with 5-bromosalicylaldehyde and 5-chlorosalicylaldehyde in the presence of (C2H5)3N and K2CO3 at room temperature, respectively. The new two organocyclotriphosphazenes bearing formyl groups were reacted with 4-cyano aniline, 2-phenyl aniline, 4-aceto aniline, 5-chloro-2-hydroxy aniline, 2-hydroxy aniline, 4-hydroxy aniline, 2-(4-morpholino)ethyl amine, 4-carboxy aniline, 4-carbomoyl aniline, 2-mercapto aniline, and 5-amino isoquonoline to prepare cyclotriphosphazene derivatives containing a Schiff base at room temperature. However, fully phenoxy-substituted cyclotriphosphazenes containing a Schiff base were isolated from the reactions of the compound 2 and 3 with 5-chloro-2-hydroxy aniline, 2-hydroxy aniline, 4-hydroxy aniline, and 2-(4-morpholino)ethyl amine. The structures of the synthesized compounds were characterized by elemental analysis, IR, and NMR (1H, 13C, 31P) spectroscopy. According to the results of the analysis, all synthesized compounds were found to be fully substituted organocyclotriphosphazenes, such as hexa[4-bromo-2-(5-chloro-2-hydroxy-pheyliminomethyl)phenoxy]cyclotriphosphaze (2a). All cyclotriphosphazene derivatives synthesized gave fluorescence emission peaks in range between 300 nm and 410 nm. 相似文献
106.
In this study, the effect of addition Calcium carbonate (CaCO3) filler component on solid state thermal decomposition procedures of Polypropylene-Low Density Polyethylene (PP-LDPE; 90/10 wt%) blends involving different amounts (5, 10, 20 wt%) Calcium carbonate (CaCO3) was investigated using thermogravimetry in dynamic nitrogen atmosphere at different heating rates. An integral composite procedure involving the integral iso-conversional methods such as the Tang (TM), the Kissinger-Akahira-Sunose method (KAS), the Flynn-Wall-Ozawa (FWO), an integral method such as Coats-Redfern (CR) and master plots method were employed to determine the kinetic model and kinetic parameters of the decomposition processes under non-isothermal conditions. The Iso-conversional methods indicated that the thermal decomposition reaction should conform to single reaction model. The results of the integral composite procedures of TG data at various heating rates suggested that thermal processes of PP-LDPE-CaCO3 composites involving different amounts of CaCO3 filler component (5, 10, 20 wt%) followed a single step with approximate activation energies of 226.7, 248.9, and 252.0 kJ.mol? 1 according to the FWO method, respectively and those of 231.3, 240.1 and 243.0 kJ mol? 1 at 5°C min? 1 according to the Coats-Redfern method, the reaction mechanisms of all the composites was described from the master plots methods and are Pn model for composite C-1, Rn model for composites C-2 and C-3, respectively. It was found that the thermal stability, activation energy and thermal decomposition process changed by the increasing CaCO3 filler weight in composite structure. 相似文献
107.
Serpil Aközcan Mücahit Yılmaz Fatih Külahcı 《Journal of Radioanalytical and Nuclear Chemistry》2014,299(1):95-101
Concentrations of 238U, 232Th, 226Ra, 40K and 137Cs are measured in collected soil samples from various locations in the Thrace region of Turkey. The activity concentrations range from 12.82 to 101.75 Bq kg?1 d.w. (dry weight) for 238U, from 5.16 to 73.34 Bq kg?1 d.w. for 232Th, from 185.54 to 5399 Bq kg?1 d.w. for 40K and from 11.42 to 90.73 Bq kg?1 d.w. for 226Ra. In addition to naturally occurring radionuclides, 137Cs activity concentration is determined between 3.05 and 46.78 Bq kg?1 d.w. for soil samples. Determination of the radiological hazard is achieved through calculations of the external terrestrial gamma dose rate in air (nGy h?1) and annual effective dose rate (mSv year?1) and the results are compared with the similar works in different countries. 相似文献
108.
Emre GÜZEL Fatih S
NMEZ Sultan ERKAN Kübra IKRIKI Adem ERGÜN Nahit GENER Oktay ARSLAN Makbule B KOAK 《Turkish Journal of Chemistry》2020,44(6):1565
The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes ( 1 and 2 ) are reported for the first time. The binding of p-sulfonylphenoxy moieties to the phthalocyanine structure favors excellent solubilities in water, as well as providing an inhibition effect on carbonic anhydrase (CA) I and II isoenzymes and paraoxonase (PON1) enzyme. According to biological activity results, both complexes inhibited hCA I, hCA II, and PON1. Whereas 1 and 2 showed moderate hCA I and hCA II (off-target cytosolic isoforms) inhibitory activity (Ki values of 26.09 µM and 43.11 µM for hCA I and 30.95 µM and 33.19 µM for hCA II, respectively), they exhibited strong PON1 (associated with high-density lipoprotein [HDL]) inhibitory activity (Ki values of 0.37 µM and 0.27 µM, respectively). The inhibition kinetics were analyzed by Lineweaver–Burk double reciprocal plots. It revealed that 1 and 2 were noncompetitive inhibitors against PON1, hCA I, and hCA II. These complexes can be more advantageous than other synthetic CA and PON inhibitors due to their water solubility. Docking studies were carried out to examine the interactions between hCA I, hCA II, and PON1 inhibitors and metal complexes at a molecular level and to predict binding energies. 相似文献
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110.
M. Fatih Tasgetiren Yun-Chia Liang Mehmet Sevkli Gunes Gencyilmaz 《European Journal of Operational Research》2007
In this paper, a particle swarm optimization algorithm (PSO) is presented to solve the permutation flowshop sequencing problem (PFSP) with the objectives of minimizing makespan and the total flowtime of jobs. For this purpose, a heuristic rule called the smallest position value (SPV) borrowed from the random key representation of Bean [J.C. Bean, Genetic algorithm and random keys for sequencing and optimization, ORSA Journal of Computing 6(2) (1994) 154–160] was developed to enable the continuous particle swarm optimization algorithm to be applied to all classes of sequencing problems. In addition, a very efficient local search, called variable neighborhood search (VNS), was embedded in the PSO algorithm to solve the well known benchmark suites in the literature. The PSO algorithm was applied to both the 90 benchmark instances provided by Taillard [E. Taillard, Benchmarks for basic scheduling problems, European Journal of Operational Research, 64 (1993) 278–285], and the 14,000 random, narrow random and structured benchmark instances provided by Watson et al. [J.P. Watson, L. Barbulescu, L.D. Whitley, A.E. Howe, Contrasting structured and random permutation flowshop scheduling problems: Search space topology and algorithm performance, ORSA Journal of Computing 14(2) (2002) 98–123]. For makespan criterion, the solution quality was evaluated according to the best known solutions provided either by Taillard, or Watson et al. The total flowtime criterion was evaluated with the best known solutions provided by Liu and Reeves [J. Liu, C.R. Reeves, Constructive and composite heuristic solutions to the P∥∑Ci scheduling problem, European Journal of Operational Research 132 (2001) 439–452], and Rajendran and Ziegler [C. Rajendran, H. Ziegler, Ant-colony algorithms for permutation flowshop scheduling to minimize makespan/total flowtime of jobs, European Journal of Operational Research, 155(2) (2004) 426–438]. For the total flowtime criterion, 57 out of the 90 best known solutions reported by Liu and Reeves, and Rajendran and Ziegler were improved whereas for the makespan criterion, 195 out of the 800 best known solutions for the random and narrow random problems reported by Watson et al. were improved by the VNS version of the PSO algorithm. 相似文献