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21.
We report high-power vacuum-ultraviolet (vuv) generation at the Lyman- alpha wavelength of 121.6nm , using a simple experimental system. vuv radiation is produced through two-photon-resonant difference-frequency mixing with a tunable ArF excimer laser and a Nd:YAG-pumped dye laser. Using phase-matched mixtures of Kr and Ar at a total pressure of 650 mbar, we produced 7-microJ energies at Lyman- alpha in approximately 5ns (1.3kW) , as measured directly with a pyroelectric energy probe. Measurements indicate that higher powers are possible with system optimization. A tuning range of 0.1nm was achieved for a fixed gas mole fraction at a total pressure of 650 mbar. Qualitative agreement is found between measured tuning profiles and theoretical predictions. 相似文献
22.
Haresh S. Kalasariya Nikunj B. Patel Akanksha Yadav Kahkashan Perveen Virendra Kumar Yadav Faris M. Munshi Krishna Kumar Yadav Shamshad Alam You-Kyung Jung Byong-Hun Jeon 《Molecules (Basel, Switzerland)》2021,26(24)
Cosmetic industries are highly committed to finding natural sources of functional active constituents preferable to safer materials to meet consumers’ demands. Marine macroalgae have diversified bioactive constituents and possess potential benefits in beauty care products. Hence, the present study was carried out to characterize the biochemical profile of marine macroalga Chaetomorpha crassa by using different techniques for revealing its cosmetic potentials. In results, the FTIR study characterized the presence of different bioactive functional groups that are responsible for many skin-beneficial compounds whereas six and fifteen different important phycocompounds were found in GCMS analysis of ethanolic and methanolic extracts, respectively. In the saccharide profile of C. crassa, a total of eight different carbohydrate derivatives were determined by the HRLCMS Q-TOF technique, which showed wide varieties of cosmetic interest. In ICP AES analysis, Si was found to be highest whereas Cu was found to be lowest among other elements. A total of twenty-one amino acids were measured by the HRLCMS-QTOF technique, which revealed the highest amount of the amino acid, Aspartic acid (1207.45 nmol/mL) and tyrosine (106.77 nmol/mL) was found to be the lowest in amount among other amino acids. Their cosmetic potentials have been studied based on previous research studies. The incorporation of seaweed-based bioactive components in cosmetics has been extensively growing due to its skin health-promoting effects. 相似文献
23.
Adel M. Ahmad Hamdoon A. Mohammed Tarek M. Faris Abeer S. Hassan Hebatallah B. Mohamed Mahmoud I. El Dosoky Esam M. Aboubakr 《Molecules (Basel, Switzerland)》2021,26(24)
The study aimed to develop a new glutathione (GSH) oral formulation to enhance the delivery of GSH and counter the nephrotoxicity of the anticancer drug, cyclophosphamide (CP). A nanostructured lipid carrier glutathione formulation (GSH-NLCs) composed of glutathione (500 mg), stearic and oleic acid (300 mg, each), and Tween® 80 (2%, w/v) was prepared through the emulsification-solvent-evaporation technique, which exhibited a 452.4 ± 33.19 nm spheroidal-sized particulate material with narrow particle size distributions, −38.5 ± 1.4 mV zeta potential, and an entrapment efficiency of 79.8 ± 1.9%. The GSH formulation was orally delivered, and biologically tested to ameliorate the CP-induced renal toxicity in a rat model. Detailed renal morphology, before and after the GSH-NLCs administration, including the histopathological examinations, confirmed the ameliorating effects of the prepared glutathione formulation together with its safe oral delivery. CP-induced oxidative stress, superoxide dismutase depletion, elevation of malondialdehyde levels, depletion of Bcl-2 concentration levels, and upregulated NF-KB levels were observed and were controlled within the recommended and near normal/control levels. Additionally, the inflammatory mediator marker, IL-1β, serum levels were marginally normalized by delivery of the GHS-NLCs formulation. Oral administration of the pure glutathione did not exhibit any ameliorating effects on the renal tissues, which suggested that the pure glutathione is reactive and is chemically transformed during the oral delivery, which affected its pharmacological action at the renal site. The protective effects of the GSH-NLCs formulation through its antioxidant and anti-inflammatory effects suggested its prominent role in containing CP-induced renal toxicity and renal tissue damage, together with the possibility of administrating higher doses of the anticancer drug, cyclophosphamide, to achieve higher and effective anticancer action in combination with the GSH-NLCs formulation. 相似文献
24.
Ş. Yalçin D.R. Crosley G.P. Smith G.W. Faris 《Applied physics. B, Lasers and optics》1999,68(1):121-130
Received: 17 June 1998/Revised version: 17 September 1998 相似文献
25.
Faris Alrumaihi Masood Alam Khan Ali Yousif Babiker Mohammed Alsaweed Faizul Azam Khaled S. Allemailem Ahmad A. Almatroudi Syed Rizwan Ahamad Mahdi H. Alsugoor Khloud Nawaf Alharbi Nahlah Makki Almansour Arif Khan 《Molecules (Basel, Switzerland)》2022,27(7)
Garlic’s main bioactive organosulfur component, diallyl trisulfide (DATS), has been widely investigated in cancer models. However, DATS is not suitable for clinical use due to its low solubility. The current study seeks to improve DATS bioavailability and assess its chemopreventive and chemosensitizing properties in an AOM-induced colorectal cancer model. The polyethylene glycol coated Distearoylphosphatidylcholine/Cholesterol (DSPC/Chol) comprising DATS-loaded DATSL and doxorubicin (DOXO)-encapsulated DOXL liposomes was prepared and characterized. The changes in the sensitivity of DATS and DOXO by DATSL and DOXL were evaluated in RKO and HT-29 colon cancer cells. The synergistic effect of DATSL and DOXL was studied by cell proliferation assay in the combinations of IC10, IC25, and IC35 of DATSL with the IC10 of DOXL. AOM, DATSL, and DOXL were administered to different groups of mice for a period of 21 weeks. The data exhibited ~93% and ~46% entrapment efficiency of DATSL and DOXL, respectively. The size of sham liposomes was 110.5 nm, whereas DATSL and DOXL were 135.5 nm and 169 nm, respectively. DATSL and DOXL exhibited significant sensitivity in the cell proliferation experiment, lowering their IC50 doses by more than 8- and 14-fold, respectively. However, the DATSL IC10, IC25, and IC35 showed escalating chemosensitivity, and treated the cells in combination with DOXL IC10. Analysis of histopathological, cancer marker enzymes, and antioxidant enzymes revealed that the high dose of DATSL pretreatment and DOXL chemotherapy is highly effective in inhibiting AOM-induced colon cancer promotion. The combination of DATSL and DOXL indicated promise as a colorectal cancer treatment in this study. Intermolecular interactions of DATS and DOXO against numerous cancer targets by molecular docking indicated MMP-9 as the most favourable target for DATS exhibiting binding energy of −4.6 kcal/mol. So far, this is the first research to demonstrate the chemopreventive as well as chemosensitizing potential of DATSL in an animal model of colorectal cancer. 相似文献
26.
We demonstrate a new method for performing protein assays with very small volumes ( approximately 1.7 muL to 14 pL). Using a laser to modify local surface energy, we manipulate, fuse, and mix droplets containing horseradish peroxidase and its substrates. A detection limit of approximately 30 attomoles of reacting enzyme was measured by optical absorption. We discuss the possibility of extending this lower limit to zeptomoles of enzyme. 相似文献
27.
A time dependent approach to self-adjointness is presented and it is applied to quantum mechanical Hamiltonians which are not semi-bounded. Sufficient conditions are given for self-adjointness of Schrödinger and Dirac Hamiltonians with potentials which are unbounded at infinity. The method is the introduction of an auxiliary operatorN≧0 whose rate of change (commutator with the Hamiltonian) is bounded by a multiple ofN. 相似文献
28.
William G. Faris 《Foundations of Physics》1982,12(1):1-26
Stochastic mechanics may be used to described the spin of atomic particles. The spin variables have the same expectations as in quantum mechanics, but not the same distributions. They play the role of hidden variables that influence, but do not determine, the results of Stern-Gerlach experiments involving magnets. During the course of such an experiment spin becomes correlated with position. The case of two particles with zero total spin occurs in Bohm's version of the Einstein-Rosen-Podolsky experiment.This material is based upon work supported by the National Science Foundation under Grant No. MCS-8002945. 相似文献
29.
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