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51.
V. I. Gel’fgat 《Computational Mathematics and Mathematical Physics》2013,53(8):1057-1061
Formulas for inverting nonsingular Toeplitz matrices with complex entries are derived. These formulas either refine known ones or are new. They make it possible to develop economical algorithms for calculating products of inverse Toeplitz matrices with vectors. 相似文献
52.
53.
T. E. Sukhanova V. A. Bershtein S. V. Valueva M. E. Vylegzhanina A. Ya. Volkov L. N. Borovikova L. M. Egorova V. A. Ryzhov M. L. Gel’fond 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2014,88(3):544-550
Water-soluble polymers poly-N-methacryloyloxyethyl-N,N,N-trimethylammonium methyl sulfate and poly(methacrylic acid) are found on the basis of spectral, thermophysical, structural, and morphological studies to form stable complexes with Photodithazine photosensitizer. 相似文献
54.
Haresh S. Kalasariya Nikunj B. Patel Akanksha Yadav Kahkashan Perveen Virendra Kumar Yadav Faris M. Munshi Krishna Kumar Yadav Shamshad Alam You-Kyung Jung Byong-Hun Jeon 《Molecules (Basel, Switzerland)》2021,26(24)
Cosmetic industries are highly committed to finding natural sources of functional active constituents preferable to safer materials to meet consumers’ demands. Marine macroalgae have diversified bioactive constituents and possess potential benefits in beauty care products. Hence, the present study was carried out to characterize the biochemical profile of marine macroalga Chaetomorpha crassa by using different techniques for revealing its cosmetic potentials. In results, the FTIR study characterized the presence of different bioactive functional groups that are responsible for many skin-beneficial compounds whereas six and fifteen different important phycocompounds were found in GCMS analysis of ethanolic and methanolic extracts, respectively. In the saccharide profile of C. crassa, a total of eight different carbohydrate derivatives were determined by the HRLCMS Q-TOF technique, which showed wide varieties of cosmetic interest. In ICP AES analysis, Si was found to be highest whereas Cu was found to be lowest among other elements. A total of twenty-one amino acids were measured by the HRLCMS-QTOF technique, which revealed the highest amount of the amino acid, Aspartic acid (1207.45 nmol/mL) and tyrosine (106.77 nmol/mL) was found to be the lowest in amount among other amino acids. Their cosmetic potentials have been studied based on previous research studies. The incorporation of seaweed-based bioactive components in cosmetics has been extensively growing due to its skin health-promoting effects. 相似文献
55.
Adel M. Ahmad Hamdoon A. Mohammed Tarek M. Faris Abeer S. Hassan Hebatallah B. Mohamed Mahmoud I. El Dosoky Esam M. Aboubakr 《Molecules (Basel, Switzerland)》2021,26(24)
The study aimed to develop a new glutathione (GSH) oral formulation to enhance the delivery of GSH and counter the nephrotoxicity of the anticancer drug, cyclophosphamide (CP). A nanostructured lipid carrier glutathione formulation (GSH-NLCs) composed of glutathione (500 mg), stearic and oleic acid (300 mg, each), and Tween® 80 (2%, w/v) was prepared through the emulsification-solvent-evaporation technique, which exhibited a 452.4 ± 33.19 nm spheroidal-sized particulate material with narrow particle size distributions, −38.5 ± 1.4 mV zeta potential, and an entrapment efficiency of 79.8 ± 1.9%. The GSH formulation was orally delivered, and biologically tested to ameliorate the CP-induced renal toxicity in a rat model. Detailed renal morphology, before and after the GSH-NLCs administration, including the histopathological examinations, confirmed the ameliorating effects of the prepared glutathione formulation together with its safe oral delivery. CP-induced oxidative stress, superoxide dismutase depletion, elevation of malondialdehyde levels, depletion of Bcl-2 concentration levels, and upregulated NF-KB levels were observed and were controlled within the recommended and near normal/control levels. Additionally, the inflammatory mediator marker, IL-1β, serum levels were marginally normalized by delivery of the GHS-NLCs formulation. Oral administration of the pure glutathione did not exhibit any ameliorating effects on the renal tissues, which suggested that the pure glutathione is reactive and is chemically transformed during the oral delivery, which affected its pharmacological action at the renal site. The protective effects of the GSH-NLCs formulation through its antioxidant and anti-inflammatory effects suggested its prominent role in containing CP-induced renal toxicity and renal tissue damage, together with the possibility of administrating higher doses of the anticancer drug, cyclophosphamide, to achieve higher and effective anticancer action in combination with the GSH-NLCs formulation. 相似文献
56.
Mushtaq A. Ansari Ahmed Nadeem Saleh A. Bakheet Sabry M. Attia Mudassar Shahid Faris S. Alyousef Mohammed A. Alswailem Mohammed Alqinyah Sheikh F. Ahmad 《Molecules (Basel, Switzerland)》2021,26(7)
Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affecting the synovial joints. A highly potent antagonist of C-C chemokine receptor 5 (CCR5), maraviroc (MVC), plays an essential role in treating several infectious diseases but has not yet been evaluated for its potential effects on RA development. This study focused on evaluating the therapeutic potential of MVC on collagen-induced arthritis (CIA) in DBA/1J mice. Following CIA induction, animals were treated intraperitoneally with MVC (50 mg/kg) daily from day 21 until day 35 and evaluated for clinical score and histopathological changes in arthritic inflammation. We further investigated the effect of MVC on Th9 (IL-9, IRF-4, and GATA3) and Th17 (IL-21R, IL-17A, and RORγT) cells, TNF-α, and RANTES in CD8+ T cells in the spleen using flow cytometry. We also assessed the effect of MVC on mRNA and protein levels of IL-9, IL-17A, RORγT, and GATA3 in knee tissues using RT-PCR and western blot analysis. MVC treatment in CIA mice attenuated the clinical and histological severity of inflammatory arthritis, and it substantially decreased IL-9, IRF4, IL-21R, IL-17A, RORγT, TNF-α, and RANTES production but increased GATA3 production in CD8+ T cells. We further observed that MVC treatment decreased IL-9, IL-17A, and RORγt mRNA and protein levels and increased those of GATA3. This study elucidates the capacity of MVC to ameliorate the clinical and histological signs of CIA by reducing pro-inflammatory responses, suggesting that MVC may have novel therapeutic uses in the treatment of RA. 相似文献
57.
Orit Seri-Livni Cecile Saguy Faris Horani Efrat Lifshitz Dima Cheskis 《physica status solidi b》2021,258(3):2170015
58.
Faris Alrumaihi Masood Alam Khan Ali Yousif Babiker Mohammed Alsaweed Faizul Azam Khaled S. Allemailem Ahmad A. Almatroudi Syed Rizwan Ahamad Mahdi H. Alsugoor Khloud Nawaf Alharbi Nahlah Makki Almansour Arif Khan 《Molecules (Basel, Switzerland)》2022,27(7)
Garlic’s main bioactive organosulfur component, diallyl trisulfide (DATS), has been widely investigated in cancer models. However, DATS is not suitable for clinical use due to its low solubility. The current study seeks to improve DATS bioavailability and assess its chemopreventive and chemosensitizing properties in an AOM-induced colorectal cancer model. The polyethylene glycol coated Distearoylphosphatidylcholine/Cholesterol (DSPC/Chol) comprising DATS-loaded DATSL and doxorubicin (DOXO)-encapsulated DOXL liposomes was prepared and characterized. The changes in the sensitivity of DATS and DOXO by DATSL and DOXL were evaluated in RKO and HT-29 colon cancer cells. The synergistic effect of DATSL and DOXL was studied by cell proliferation assay in the combinations of IC10, IC25, and IC35 of DATSL with the IC10 of DOXL. AOM, DATSL, and DOXL were administered to different groups of mice for a period of 21 weeks. The data exhibited ~93% and ~46% entrapment efficiency of DATSL and DOXL, respectively. The size of sham liposomes was 110.5 nm, whereas DATSL and DOXL were 135.5 nm and 169 nm, respectively. DATSL and DOXL exhibited significant sensitivity in the cell proliferation experiment, lowering their IC50 doses by more than 8- and 14-fold, respectively. However, the DATSL IC10, IC25, and IC35 showed escalating chemosensitivity, and treated the cells in combination with DOXL IC10. Analysis of histopathological, cancer marker enzymes, and antioxidant enzymes revealed that the high dose of DATSL pretreatment and DOXL chemotherapy is highly effective in inhibiting AOM-induced colon cancer promotion. The combination of DATSL and DOXL indicated promise as a colorectal cancer treatment in this study. Intermolecular interactions of DATS and DOXO against numerous cancer targets by molecular docking indicated MMP-9 as the most favourable target for DATS exhibiting binding energy of −4.6 kcal/mol. So far, this is the first research to demonstrate the chemopreventive as well as chemosensitizing potential of DATSL in an animal model of colorectal cancer. 相似文献
59.
B. D. Gel’man 《Mathematical Notes》2005,78(1-2):194-203
In the present paper, we prove a fixed-point theorem for completely continuous multivalued mappings defined on a bounded convex closed subset X of the Hilbert space H which satisfies the tangential condition
, where T
X
(x) is the cone tangent to the set X at a point x. The proof of this theorem is based on the method of single-valued approximations to multivalued mappings. In this paper, we consider a simple approach for constructing single-valued approximations to multivalued mappings. This approach allows us not only to simplify the proofs of already-known theorems, but also to obtain new statements needed to prove the main theorem in this paper.__________Translated from Matematicheskie Zametki, vol. 78, no. 2, 2005, pp. 212–222.Original Russian Text Copyright © 2005 by B. D. Gel’man. 相似文献
60.
John W. Fowler Esma S. Gel Murat M. Köksalan Pekka Korhonen Jon L. Marquis Jyrki Wallenius 《European Journal of Operational Research》2010
We present a new hybrid approach to interactive evolutionary multi-objective optimization that uses a partial preference order to act as the fitness function in a customized genetic algorithm. We periodically send solutions to the decision maker (DM) for her evaluation and use the resulting preference information to form preference cones consisting of inferior solutions. The cones allow us to implicitly rank solutions that the DM has not considered. This technique avoids assuming an exact form for the preference function, but does assume that the preference function is quasi-concave. This paper describes the genetic algorithm and demonstrates its performance on the multi-objective knapsack problem. 相似文献