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The purpose of this study was to examine the phonatory characteristics of pig, sheep, and cow excised larynges and to find out which of these animal species is the best model for human phonation. Excised pig, sheep, and cow larynges were prepared and mounted over a tapered tube on the excised bench that supplied pressurized, heated, and humidified air in a manner similar to that for excised canine models. Each excised larynx was subjected to a series of pressure-flow experiments with adduction as major control parameter. The subglottal pressure, electroglottograph (EGG), mean flow rate, audio signal, and sound pressure level were recorded during each experiment. EGG signal was used to extract the fundamental frequency. It was found that pressure-frequency relations were nonlinear for these species with large rate of frequency changes for the pig. The average oscillation frequencies for these species were 220+/-57 Hz for the pig, 102+/-33 Hz for the sheep, and 73+/-10 Hz for the cow. The average phonation threshold pressure for the pig was 7.4+/-2.0 cm H(2)O, 6.9+/-2.9 cm H(2)O for the sheep, and 4.4+/-2.3 cm H(2)O for the cow. 相似文献
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Ghorbani AR Momenbeik F Khorasani JH Amini MK 《Analytical and bioanalytical chemistry》2004,379(3):439-444
A super-modified simplex (SMS) method has been used to optimize the mobile phase used for separation of seven water-soluble vitamins in multivitamin tablets by gradient micellar liquid chromatography (MLC) with ultraviolet (UV) detection at 254, 295, and 361 nm. Effect of column temperature and addition of organic modifier to the mobile phase on separation efficiency were investigated: the appropriate conditions used were a temperature of 35 degrees C and 1-butanol modifier. The sodium dodecyl sulfate (SDS) concentration, pH, and 1-butanol% in the mobile phase were chosen for simultaneous optimization using the SMS method. The optimum mobile phase was found to be 16 mmol L(-1) (mM) SDS, 0.02 M phosphate buffer, pH 3.6, and a gradient of 3.5-10% (v/v) butanol. The total analysis time for vitamins was 75 min. The analytical parameters including linearity ( r>0.9970), limit of detection (0.12-50 micro g mL(-1)), precision of method (relative standard deviation (RSD) <8.90%), and accuracy obtained by the recovery assay (88-103%) support the usefulness of the proposed method for the determination of the water-soluble vitamins. 相似文献
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Gustavo E. Imoberdorf Fariborz Taghipour Madjid Mohseni 《Journal of photochemistry and photobiology. A, Chemistry》2008,198(2-3):169-178
For modeling and optimization of photoreactors, knowing radiation distribution inside the reactor is essential because the kinetics of photochemical and photocatalytic reactions are strongly dependent on the local incident radiation. In this work, a Monte Carlo multi-lamp radiation model is proposed. The model takes into account the reflection on the surface of the lamps, the refraction in the quartz lamp envelope, as well as the adsorption and the isotropic re-emission of radiation in the mercury vapor of the lamp. To quantify the shadowing effect among the lamps, the effective transmittance through a UV-lamp turned on, a lamp turned off, and a lamp quartz envelope have been measured. For validation purposes, experimental measurements have been performed using one, two, and three lamps. The model predictions show good agreement with the experimental results. Finally, in order to simplify the numerical solution of the model, the validity of assuming the lamps 100% opaque and 100% transparent have been analyzed. 相似文献
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Seyed Ahmad Mohajeri Hossein Hosseinzadeh Fariborz Keyhanfar Javad Aghamohammadian 《Journal of separation science》2010,33(15):2302-2309
A new molecularly imprinted polymer for extraction of crocin from saffron stigmas was prepared using gentiobiose (a glycoside moiety in crocin structure) as a template. Crocin binding to gentiobiose imprinted polymer (Gent‐MIP) was studied in comparison with a blank nonimprinted polymer in aqueous media. Affinity of the Gent‐MIP for the crocin was more than the nonimprinted polymer at all concentrations. In Scatchard analysis, the number of binding sites in each gram of polymer (maximum binding sites) and dissociation constant of crocin to binding sites were 18.4 μmol/g polymer and 11.2 μM, respectively. The Gent‐MIP was then used as the sorbent in an SPE method for isolation and purification of crocin from methanolic extract of saffron stigmas. The recovery of crocin, safranal and picrocrocin was determined in washing and elution steps. The Gent‐MIP had significantly higher affinity for crocin than other compounds and enabled selective extraction of crocin with a high recovery (84%) from a complex mixture. The results demonstrated the possibility of using a part of a big molecule in preparing a molecularly imprinted polymer with a good selectivity for the main structure. 相似文献
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Glottal adduction is a primary laryngeal variable that helps to determine glottal configuration and phonatory output. Greater adduction of the vocal folds can be produced by narrowing the gap between the vocal processes or by bulging the medial surface of the vocal folds. This study examined phonatory effects due to changing the degree of bulging using a computational model. Bulging was modeled as a quadratic surface and was related to active muscle stress. Results indicated that bulging had a significant effect on glottal flow resistance, maximum glottal width and area, and mean glottal volume velocity. The results are discussed relative to clinical issues of hyperfunction. 相似文献