Synthese und Reaktionen von Bicyclo[6.4.0]dodecan-3-carbonsäure-Derivaten

Synthesis and Reactions of the Bicyclo[6.4.0]dodecane-3-carboxylic Acid Derivatives The synthesis and some consecutive reactions of the compounds 5-8 , derivatives of bicyclo[6.4.0]dodecane-3-carboxylic acid ( 1 ), are described. The esters 7 and 8 can be obtained by Baeyer-Villiger oxidation of 2-hydroxy-8-methyltricyclo[7.3.1.0^2,7]tridecan-13-one ( 4 ) and subsequent hydrolysis of the lactone 5 . The structure and configuration of these compounds has been evaluated by spectroscopic techniques (mainly 2D-NMR methods). The formation of 7 via 1,2-H shift and subsequent isomerization to 8 has been studied. The esters 11 and 13 are formed stereospecifically from 7 and 8 .     

New membrane materials for potassium-selective ion-sensitive field-effect transistors

Several polymeric materials were studied as membrane materials for potassium-selective ion-sensitive field-effect transistors (ISFETs) to overcome the problems related with the use of conventional plasticized poly(vinyl chloride) membranes casted on ISFET gate surfaces. Several acrylate materials, such as ACE, Epocryl and derivatives, showed no reproducible results. Three room-temperature vulcanizing (RTV)-type silicone rubbers were tested. The addition-type RTV-2 silicone rubber was not suitable as a membrane material, but the condensation-type RTV-1 and especially the RTV-2 silicone rubber showed good results. ISFETs with a Silopren membrane showed a durability of at least 2 months.     

Analytical quality control by solid sampling GFAAS in the production of animal tissue reference materials: lead and cadmium in bovine liver reference materials

Summary The function of solid sampling graphite furnace atomic absorption spectrometry (SS-GFAAS) in the laboratory-internal preparation, production and standardization of bovine liver reference material is described. Analytical quality assurance was achieved by using a wet digestion decomposition procedure and GFAAS (WD-GFAAS) as well as three different methods of SS-GFAAS. It will be shown, that SS-GFAAS is an adequate and efficacious method of analytical quality control in the production of reference materials. Details are given about the preliminary steps of sample selection and preparation, applying SS-GFAAS both as a screening method and for the detection of contamination during the production of the reference materials. The element contents of the four bovine liver materials measured after decomposition with nitric acid in the open system by GFAAS and also by Flame-AAS, using the slotted tube atom trap, are compared statistically with the results obtained by SS-GFAAS. In solid sampling analyses three different systems were applied: a solid sampling ZAA-spectrometer with platform-boat, a D₂AA-spectrometer with solid sampling graphite tube and platform-drawer and an autoprobe-D₂AA-spectrometer with solid sampling autoprobe and graphite tube.     

Heteronuclear solid-state correlation spectroscopy

Two-dimensional NMR methods are proposed for correlating the spectra of abundant and dilute spins in solids. The techniques simplify assignment and permit determination of shielding tensors even when extensive overlaps occur. Spin diffusion among abundant spins can be observed indirectly.     

Effect of Substituents and of Wavelength of Irradiation on the Photo-Fries-Rearrangement of Enol-Esters Preliminary Communication

Enol-esters 1a-1e undergo clean Photo-Fries-rearrangements without side reactions. With anthroyl derivatives the reaction is observed only at 254 nm, not at 366 nm.     

Theory of chirality functions,generalized for molecules with chiral ligands

The theory of chirality functions described in a previous publication is generalized to allow for chiral ligands. In the earlier theory, all symmetry operations of the molecular frame could be thought of as permutations of the ligands among the sites; in the present work, improper rotations not only permute the ligands, but convert them into mirror images. The group that generates all isomers from a given ordered molecule belonging to a frame with n sites is now the hyperoctahedral group of order 2ⁿ n! consisting of all possible combinations of permutations and site reflections. The representation theory of these groups is described, and applied to the problem of constructing qualitatively complete chirality functions, and of deciding which ligand partitions, and which isomer mixtures, are chiral. It is found useful to classify chiral representations of the covering group as ligand specific and class specific. The ligand specific representations describe chiral properties which are common to all frames and arise purely from the chirality of the ligands, while the class specific representations describe the chiral properties of the frame. A number of examples are explicitly worked out.     

Pentadienyls vs cyclopentadienyls and reversal of metal-ligand bonding affinity with metal oxidation state: synthesis, molecular structures, and electronic structures of high-valent zirconium pentadienyl complexes

Molecules of the form Cp(6,6-dmch)ZrX(2) (Cp = eta(5)-cyclopentadienyl, X = Cl, Br, I; 6,6-dmch = eta(5)-6,6-dimethylcyclohexadienyl) have been synthesized, and the molecular and electronic structures have been investigated. These molecules allow direct comparison of the bonding and properties of pentadienyl and cyclopentadienyl ligands in the same high-oxidation-state metal complexes. Unlike the well-known Cp(2)ZrX(2) analogues, these Cp(6,6-dmch)ZrX(2) molecules are intensely colored, indicating significantly different relative energies of the frontier orbitals. Also unusual, the average Zr-C distances to the 6,6-dmch pentadienyl ligand are about 0.1 A longer than the average Zr-C distances to the cyclopentadienyl ligand for these Zr(IV) complexes, opposite of what is observed for the Zr(II) complex Cp(2,6,6-tmch)Zr(PMe(3))(2) (tmch = eta(5)-2,6,6-trimethylcyclohexadienyl), reflecting a dramatic reversal in the favorability of the bonding depending on the metal oxidation state. The experimental and computational results indicate that the color of the Cp(6,6-dmch)ZrX(2) complexes is due to a 6,6-dmch ligand-to-metal charge-transfer band. Compared to the Cp(2)ZrX(2) analogues, the Cp(6,6-dmch)ZrX(2) molecules have a considerably less stable HOMO that is pentadienyl-based and an essentially unchanged metal-based LUMO. Also, the lowest unoccupied orbital of pentadienyl is stabilized relative to cyclopentadienyl and becomes a better potential delta electron acceptor, thus contributing to the differences in structure and reactivity of the low-valent and high-valent metal complexes.     

pH sensitivity of Si--C linked organic monolayers on crystalline silicon surfaces.

The electrochemical behavior of Si--C linked organic monolayers is studied in electrolyte-insulator-Si devices, under conditions normally encountered in potentiometric biosensors, to gain fundamental knowledge on the behavior of such Si electrodes under practical conditions. This is done via titration experiments, Mott-Schottky data analysis, and data fitting using a site-binding model. The results are compared with those of native SiO(2) layers and native SiO(2) layers modified with hexamethyldisilazane. All samples display pH sensitivity. The number of Si--OH groups on the alkylated samples is calculated to be less than 0.7 % of that of a pure SiO(2) insulator, which still causes a pH sensitivity of approximately 25 mV per pH unit in the pH range: 4-7. The alkylated samples hardly suffer from response changes during up- and down-going titrations, which indicates that very little oxide is additionally formed during the measurements. The pK(a) values of all samples with monolayers (4.0-4.4) are lower than that of native SiO(2) (6.0). The long-term drift (of approximately 1 mV h(-1)) is moderate. The results indicate that biosensors composed of alkylated Si substrates are feasible if a cross-sensitivity towards pH in the sensor signal is taken into account.     

Phase Equilibria and Critical Curves of Binary Ammonia–Hydrocarbon Mixtures

Liquid or dense supercritical ammonia has been suggested as an extraction fluid. It is indeed good solvent for very different classes of compounds, as can be seen from phase diagrams. Such diagrams for binary systems of ammonia and hydrocarbons are presented and discussed on the basis of their critical curves. Apparatus and methods for the measurement of phase equilibria and equation of state data of fluid mixtures at high pressure are described.