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21.
22.
Philippe Négrel Emmanuelle Petelet-Giraud 《Trends in analytical chemistry : TRAC》2011,30(8):1279-1290
Isotopes of the water molecule (δ18O and δ2H) are a well-used tool for investigating groundwater origin and history (i.e. tracing the recharge conditions over time, processes occurring during infiltration of rainwater towards aquifers and those involved in the water-rock interaction, and mixing of different waters).This review covers several large European aquifers (Portugal, France, UK, Switzerland, Germany, Hungary, and Poland), which were investigated in terms of their recharge conditions, and the story of the groundwater at a large scale, involving recent, Holocene and Pleistocene components and their eventual mixing. 相似文献
23.
Nierengarten H Leize E Breuning E Garcia A Romero-Salguero F Rojo J Lehn JM Van Dorsselaer A 《Journal of mass spectrometry : JMS》2002,37(1):56-62
The self-assembly of the terdentate ligands 1a-h, based on terpyridine-like binding sites, with octahedrally coordinated metal ions, such as Fe(II), Co(II), Cu(II), Zn(II), Cd(II), Hg(II) and Pb(II), leads to the formation of the supramolecular grid-type complexes 2a-c(M(II)), 3d-g(M(II)) and 4h(M(II)). The structures and compositions of these coordination complexes in solution were deduced from electrospray mass spectrometry (ESMS) measurements. The results agree with the data available from x-ray radiocrystallography in the solid state and/or NMR spectroscopy in solution. ESMS may be applied in cases where other methods are difficult to use or inconclusive. This study stresses the power of ESMS in supramolecular chemistry. 相似文献
24.
Le Foulon FX Braud E Fabis F Lancelot JC Rault S 《Journal of combinatorial chemistry》2005,7(2):253-257
A 1140-library of thiophene ureidoacids was synthesized by the reaction of a set of 60 primary or secondary amines with a number of 19 thieno[3,2-d]- or thieno[2,3-d][1,3]oxazine-2,4-diones. All compounds were obtained by a simple solution-phase combinatorial strategy on a 200-400-mg scale with over 70% yields and purities over 80%. Sixty library members chosen at random were successfully characterized by standard 1H NMR, HPLC/MS, and IR studies. Analgesic, antalgic, and antiinflammatory potential were investigated. The 1140-member ureidothiophene carboxylic acid library will be used in high-throughput screening assays. 相似文献
25.
Kornev IA Bellaiche L Bouvier P Janolin PE Dkhil B Kreisel J 《Physical review letters》2005,95(19):196804
Ab initio simulations and experimental techniques are combined to reveal that, unlike what was commonly accepted for more than 30 years, perovskites and related materials enhance their ferroelectricity as hydrostatic pressure increases above a critical value. This unexpected high-pressure ferroelectricity is different in nature from conventional ferroelectricity because it is driven by an original electronic effect rather by long-range interactions. 相似文献
26.
Miqueu K Despagnet-Ayoub E Dyer PW Bourissou D Bertrand G 《Chemistry (Weinheim an der Bergstrasse, Germany)》2003,9(23):5858-5864
Density functional calculations are reported for complexes of general formula [(carbene)RhClL(2)] featuring model phosphino- and aminocarbenes. Both the cis and trans isomers of the rhodium(I) eta(1)-complexes (1-9) were investigated, and the influence of the rhodium co-ligands (L=ethylene, phosphine, or carbon monoxide) was evaluated. In the case of phosphinocarbenes and carbon monoxide as a ligand, a somewhat unusual coordination mode was observed, in which a significant intramolecular Cl-->C(carbene) interaction is present. The propensity of phosphino- and aminocarbenes to behave as four electron donors was also investigated both structurally and energetically on the related eta(2)-complexes 10-18. These results as a whole emphasize the structural versatility of phosphino- compared with aminocarbene complexes. 相似文献
27.
Boutreau L Léon E Salpin JY Amekraz B Moulin C Tortajada J 《European journal of mass spectrometry (Chichester, England)》2003,9(4):377-390
The analytical distinction of the most common isomeric underivatized hexoses was investigated by means of mass spectrometry experiments. Electrospray ionization and tandem mass spectrometry were used in the analysis of silver and copper-coordinated monosaccharides (D-glucose, D-galactose, D-fructose, O-methyl-alpha-D-glucose and O-methyl-beta-D-glucose). The results show that cationization by Ag(+) allows the differentiation of the three first monosaccharides while the complexes formed by association of Cu(+) with these three monosacharides display a similar reactivity that prevents stereoisomer distinction. Unlike copper, silver adduct-ions of both alpha and beta anomeric O-methyl-D-glucoses exhibit specific decomposition patterns (i.e. a loss of methanol for the alpha-anomer and a loss of silver hydride for the beta-anomer), which allow an easy characterization. A theoretical survey of selected complexes, based on the use of DFT calculations were carried out on both anomers in order to rationalize the experimental findings. 相似文献
28.
A new paclitaxel prodrug intended for use in Antibody-Directed Prodrug Therapy (ADEPT) or Prodrug Monotherapy (PMT) has been prepared. This prodrug was originally designed to be activated into the drug by human beta-glucuronidase. In order to enhance the liberation rate of paclitaxel, an elongated spacer system including a nitro-aromatic derivative and a N,N'-methylethylenediamine was incorporated between the sugar moiety and the drug. Indeed, this new prodrug proved to be activated significantly faster than a former paclitaxel prodrug containing a conventional spacer. 相似文献
29.
Chrostowska A Miqueu K Pfister-Guillouzo G Briard E Levillain J Ripoll JL 《Journal of Molecular Spectroscopy》2001,205(2):323-330
The flash vacuum thermolysis of cycloalkenyl allyl sulfides, potential precursors of unsubstituted cycloalkenethiones, has been investigated by photoelectron spectroscopy. This technique allowed us to characterize in the gas phase very reactive species of this series, the conjugated and nonconjugated cyclopentene and cyclohexenethiones, and to compare the reactivity of these compounds. The assignment of the PE spectra is supported by electronic structure calculations, particularly by the HF method at the MP2 level and the density functional theory (DFT) using the B3LYP and BP86 functionals with the 6-311G(d, p) basis set. Copyright 2001 Academic Press. 相似文献
30.
Véronique Cariou Stéphane Verdun Emmanuelle Diaz El Mostafa Qannari Evelyne Vigneau 《Advances in Data Analysis and Classification》2009,3(3):227-241
Within the scope of cluster analysis of variables, the selection of the appropriate number of clusters is of paramount interest. The strategy of determination of the appropriate number of clusters adopted herein is based on a hypothesis testing approach. It consists in testing whether the variation of a partition quality criterion between two consecutive partitions is far removed from the expected variation under the null-hypothesis stipulating a lack of structure. Three hypothesis testing strategies are detailed and compared in the scope of clustering of variables: Gap, Weighted Gap and a statistic associated with CLV methodology. Finally, an illustration is presented based on data from a preference study. 相似文献