Defined carrageenan derivatives as angiogenesis inhibitors

Three carrageenans derived from red algae and three partially modified carrageenans were tested for their ability to inhibit the formation of new blood capillaries on the chorionallantois membrane of the hen egg. It could be clearly demonstrated that they were better angiogenesis inhibitors than the standard compound suramin.     

Immunoassay methods for paralytic shellfish poisoning toxins

The current status of immunochemical techniques for analysis of paralytic shellfish poisoning (PSP) toxins is summarized. Important aspects regarding production of the biological reagents necessary for immunochemical methods, the characteristics of polyclonal and monoclonal antibodies against saxitoxin and neosaxitoxin, and the importance of test sensitivity and specificity are discussed. Applications of immunochemical techniques for PSP toxins include microtiter plate enzyme immunoasays and enzyme-linked immunofiltration assays for toxin detection, and immunoaffinity chromatography (IAC) for sample extract cleanup. A major advantage of enzyme immunoassay (EIA) is simplicity and rapidity of the test procedure, and higher sensitivity than other methods. However, quantitative agreement between EIA and mouse bioassay is dependent on antibody specificity and the toxin profile in the shellfish; thus, both over- and underestimation of total toxicity may occur. For screening purposes, however, EIAs offer major advantages over the mouse bioassay, which is criticized in Europe because of animal welfare. A major application of antibodies against PSP toxins is their use for extract cleanup by IAC, which gives highly purified extracts, thereby enhancing determination of PSP toxins by conventional physicochemical methods such as liquid chromatography. IAC can also be used to isolate PSP toxins for preparation of analytical standard solutions.     

Gelatin‐Alginate Gels and Their Enzymatic Modifications: Controlling the Delivery of Small Molecules

The release of molecules entrapped within biogels is dictated by diffusion laws. Innovative biogel architectures are conceived and tested to control small molecule delivery from gelatin gels. The ionic interactions modulate the release of small molecules. Alginate is then added to gelatin gels and further hydrolyzed; the influence of viscosity is discussed. Next, various mixed gels are compared, such as a gelatin‐alginate IPN and the original architecture of an alginate gel entrapped in a gelatin gel with or without a polysaccharidase. The relative influence of ionic interactions and diffusional constraints on the delivery of small charged molecules is explored, and a solution for controlling diffusion is proposed for any situation.

     

Messung von Rockingkurven eines polierten CaF2-Kristalls

It is reported on the measurement of rocking-curves of a polished CaF₂ crystal after stepwise removing of thin surface-layers. The discussion leads to a completion of the Raethermodel of polished surfaces by assuming an elastic deformed region under the mosaic-crystalline layer produced by the polishing process.     

Line tension and the shape of nanodroplets

Various factors are discussed which might influence the equilibrium contact angle of nanodroplets placed on a solid substrate. Special emphasis is put on the possible role of the dependence of the solid-liquid interface tension g^SL \gamma^{{{\rm SL}}}_{} on the pressure in the liquid, which in nanodrops considerably exceeds the saturation pressure. We show that certain published data regarding that dependence are meaningless because these have been deduced based on an inconsistent data analysis.     

A linearized Eulerian sound propagation model for studies of complex meteorological effects

Outdoor sound propagation is significantly affected by the topography (including ground characteristics) and the state of the atmosphere. The atmosphere on its part is also influenced by the topography. A sound propagation model and a flow model based on a numerical integration of the linearized Euler equations have been developed to take these interactions into account. The output of the flow model enables the calculation of the sound propagation in a three-dimensionally inhomogeneous atmosphere. Rigid, partly reflective, or fully absorptive ground can be considered. The linearized Eulerian (LE) sound propagation model has been validated by means of four different scenarios. Calculations of sound fields above rigid and grass-covered ground including a homogeneous atmosphere deviate from analytic solutions by < or = 1 dB in most parts of the computed domain. Calculations of sound propagation including wind and temperature gradients above rigid ground agree well with measured scale model data. Calculations of sound propagation over a screen including ground of finite impedance show little deviations to measured scale model data which are probably caused by an insufficient representation of the complex ground impedance. Further calculations included the effect of wind on shading by a screen. The results agree well with the measured scale model data.