全文获取类型
收费全文 | 905篇 |
免费 | 40篇 |
国内免费 | 2篇 |
专业分类
化学 | 767篇 |
晶体学 | 4篇 |
力学 | 8篇 |
数学 | 78篇 |
物理学 | 90篇 |
出版年
2024年 | 1篇 |
2023年 | 17篇 |
2022年 | 35篇 |
2021年 | 35篇 |
2020年 | 25篇 |
2019年 | 29篇 |
2018年 | 13篇 |
2017年 | 10篇 |
2016年 | 37篇 |
2015年 | 35篇 |
2014年 | 32篇 |
2013年 | 54篇 |
2012年 | 66篇 |
2011年 | 84篇 |
2010年 | 51篇 |
2009年 | 46篇 |
2008年 | 57篇 |
2007年 | 56篇 |
2006年 | 48篇 |
2005年 | 45篇 |
2004年 | 36篇 |
2003年 | 34篇 |
2002年 | 19篇 |
2001年 | 11篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 7篇 |
1997年 | 2篇 |
1996年 | 12篇 |
1995年 | 2篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有947条查询结果,搜索用时 2 毫秒
231.
232.
M. Elisa Cristiana Grigorescu Ileana Vasiliu M. Bulinski V. Kuncser Dana Predoi G. Filoti Aurelia Meghea Nicoleta Iftimie Maria Giurginca C. Onose 《Optical and Quantum Electronics》2007,39(4-6):523-531
The paper deals with optical and electronic properties of the aluminophosphate glasses containing Fe–Mn and Fe–Cr ion pairs in different concentration. The influence of the mixed alkali ions over the electronic properties has been investigated. The optical behavior (optical transmission) of the glass samples has been studied by UV-VIS spectroscopy and the refractive index dependency on wavelength has been discussed. The transmission spectra show features specific for the doping transition ions (TM), revealing different oxidation states of iron (Fe2+/Fe3+), manganese (Mn2+/Mn3+) and chromium (Cr3+/Cr6+) in the vitreous network. Mössbauer spectroscopy offers information regarding the TM oxidation states, redox processes and the iron coordination symmetry in the vitreous network. In the case of Fe–Mn doped glasses, the percentage of Fe2+ is about 40% and a doubled iron content leads to an increasing of Fe2+ percentage up to 53%. The replacing of lithium ions by natrium ions (mixed alkali effect) provides an increasing of the Fe2+ percentage up to 56%. The occurrence of the tetrahedral or octahedral symmetry of Fe2+ ions bonded by O2? ions depends on the transition ion nature and Li+/Na+ ratio. Infrared absorption spectra of the pair transition ions-doped aluminophosphate glasses reveal optical phonons specific for the phosphate glass matrix. 相似文献
233.
234.
Poole JS Hadad CM Platz MS Fredin ZP Pickard L Guerrero EL Kessler M Chowdhury G Kotandeniya D Gates KS 《Photochemistry and photobiology》2002,75(4):339-345
The absorption and fluorescence spectra of 3-aminobenzo-1,2,4-triazine di-N-oxide (tirapazamine) have been recorded and exhibit a dependence on solvent that correlates with the Dimroth ET30 parameter. Time-dependent density functional theory calculations reveal that the transition of tirapazamine in the visible region is pi-->pi* in nature. The fluorescence lifetime is 98+/-2 ps in water. The fluorescence quantum yield is approximately 0.002 in water. The fluorescence of tirapazamine is efficiently quenched by electron donors via an electron-transfer process. Linear Stern-Volmer fluorescence quenching plots are observed with sodium azide, potassium thiocyanate, guanosine monophosphate and tryptophan (Trp) methyl ester hydrochloride. Guanosine monophosphate, tyrosine (Tyr) methyl ester hydrochloride and Trp methyl ester hydrochloride appear to quench the fluorescence at a rate greater than diffusion control implying that these substrates complex with tirapazamine in its ground state. This complexation was detected by absorption spectroscopy. 相似文献
235.
Tung YS Vlachos F Feshitan JA Borden MA Konofagou EE 《The Journal of the Acoustical Society of America》2011,130(5):3059-3067
The activation of bubbles by an acoustic field has been shown to temporarily open the blood-brain barrier (BBB), but the trigger cause responsible for the physiological effects involved in the process of BBB opening remains unknown. Here, the trigger cause (i.e., physical mechanism) of the focused ultrasound-induced BBB opening with monodispersed microbubbles is identified. Sixty-seven mice were injected intravenously with bubbles of 1-2, 4-5, or 6-8 μm in diameter and the concentration of 10(7) numbers/ml. The right hippocampus of each mouse was then sonicated using focused ultrasound (1.5 MHz frequency, 100 cycles pulse length, 10 Hz pulse repetition frequency, 1 min duration). Peak-rarefactional pressures of 0.15, 0.30, 0.45, or 0.60 MPa were applied to identify the threshold of BBB opening and inertial cavitation (IC). Our results suggest that the BBB opens with nonlinear bubble oscillation when the bubble diameter is similar to the capillary diameter and with inertial cavitation when it is not. The bubble may thus have to be in contact with the capillary wall to induce BBB opening without IC. BBB opening was shown capable of being induced safely with nonlinear bubble oscillation at the pressure threshold and its volume was highly dependent on both the acoustic pressure and bubble diameter. 相似文献
236.
Michael Weber Peter Gierschner Anne Klassen Elisa Kasbohm Jochen K. Schubert Wolfram Miekisch Petra Reinhold Heike Khler 《Molecules (Basel, Switzerland)》2021,26(10)
Paratuberculosis is an important disease of ruminants caused by Mycobacterium avium ssp. paratuberculosis (MAP). Early detection is crucial for successful infection control, but available diagnostic tests are still dissatisfying. Methods allowing a rapid, economic, and reliable identification of animals or herds affected by MAP are urgently required. This explorative study evaluated the potential of volatile organic compounds (VOCs) to discriminate between cattle with and without MAP infections. Headspaces above fecal samples and alveolar fractions of exhaled breath of 77 cows from eight farms with defined MAP status were analyzed in addition to stable air samples. VOCs were identified by GC–MS and quantified against reference substances. To discriminate MAP-positive from MAP-negative samples, VOC feature selection and random forest classification were performed. Classification models, generated for each biological specimen, were evaluated using repeated cross-validation. The robustness of the results was tested by predicting samples of two different sampling days. For MAP classification, the different biological matrices emitted diagnostically relevant VOCs of a unique but partly overlapping pattern (fecal headspace: 19, alveolar gas: 11, stable air: 4–5). Chemically, relevant compounds belonged to hydrocarbons, ketones, alcohols, furans, and aldehydes. Comparing the different biological specimens, VOC analysis in fecal headspace proved to be most reproducible, discriminatory, and highly predictive. 相似文献
237.
Dnes Berta Magd Badaoui Sam Alexander Martino Pedro J. Buigues Andrei V. Pisliakov Nadia Elghobashi-Meinhardt Geoff Wells Sarah A. Harris Elisa Frezza Edina Rosta 《Chemical science》2021,12(40):13492
The RNA helicase (non-structural protein 13, NSP13) of SARS-CoV-2 is essential for viral replication, and it is highly conserved among the coronaviridae family, thus a prominent drug target to treat COVID-19. We present here structural models and dynamics of the helicase in complex with its native substrates based on thorough analysis of homologous sequences and existing experimental structures. We performed and analysed microseconds of molecular dynamics (MD) simulations, and our model provides valuable insights to the binding of the ATP and ssRNA at the atomic level. We identify the principal motions characterising the enzyme and highlight the effect of the natural substrates on this dynamics. Furthermore, allosteric binding sites are suggested by our pocket analysis. Our obtained structural and dynamical insights are important for subsequent studies of the catalytic function and for the development of specific inhibitors at our characterised binding pockets for this promising COVID-19 drug target.The RNA helicase (non-structural protein 13, NSP13) of SARS-CoV-2 is essential for viral replication, and it is highly conserved among the coronaviridae family, thus a prominent drug target to treat COVID-19. 相似文献
238.
A rapid and sensitive technique is needed to analyze water and soils for chlorocatechols, common environmental pollutants produced from wood pulp chlorination and other processes. The soil bacteria Pseudomonas putida, harboring plasmid pSMM50R-B', selectively express beta-galactosidase in response to 3-chlorocatechol in pure water samples. The objective of the study was to determine whether background matrices in fresh water, sea water, soils, and organic solvents interfered with 3-chlorocatechol analysis by use of a bacteria-sensing system and by high-performance liquid chromatography (HPLC). Although 3-chlorocatechol detection by HPLC was not substantially affected by the background composition of aqueous or organic solvents, HPLC was ineffective in the analysis of contaminated soils due to irreversible contaminant sorption. Whereas detection by the bacteria-sensing system was reduced in the presence of aqueous and organic solvents, interferences could be reduced by sample dilution. 3-Chlorocatechol was detected when the bacteria were added directly to contaminated soils, suggesting that the organism enhanced desorption or had access to the sorbed compounds. Results indicate that the bacteria-sensing system has wide application for detection of 3-chlorocatechols in environmental samples, especially in soils where extraction and HPLC analysis are not efficient due to extensive contaminant sorption. 相似文献
239.
Manet I Manoli F Donzello MP Viola E Andreano G Masi A Cellai L Monti S 《Organic & biomolecular chemistry》2011,9(3):684-688
A water soluble Zn(II) porphyrazine drives the conformational equilibrium of the G-quadruplex of a human telomeric sequence exclusively towards a parallel conformation upon complexation. 相似文献
240.
Tyznik AJ Farber E Girardi E Birkholz A Li Y Chitale S So R Arora P Khurana A Wang J Porcelli SA Zajonc DM Kronenberg M Howell AR 《Chemistry & biology》2011,18(12):1620-1630
Natural killer T (NKT) cells recognize glycolipids presented by CD1d. The first antigen described, α-galactosyl ceramide (αGalCer), is a potential anticancer agent whose activity depends upon IFN-γ secretion. We report two analogs of αGalCer based on a naturally occurring glycosphingolipid, plakoside A. These compounds induce enhanced IFN-γ that correlates with detergent-resistant binding to CD1d and an increased stability of the lipid-CD1d complexes on antigen-presenting cells. Structural analysis on one of the analogs indicates that it is more deeply bound inside the CD1d groove, suggesting tighter lipid-CD1d interactions. To our knowledge, this is the first example in which structural information provides an explanation for the increased lipid-CD1d stability, likely responsible for the Th1 bias. We provide insights into the mechanism of IFN-γ-inducing compounds, and because our compounds activate human NKT cells, they could have therapeutic utility. 相似文献