Electrochemical conversions of alkyl alkylidenecyanoacetates into 3-substituted dialkyl 1,2-dicyanocyclopropane-1,2-dicarboxylates

Electrolysis of alkyl alkylidenecyanoacetates in an undivided cell in the presence of alkali metal halides as mediators afforded 3-substituted dialkyl 1,2-dicyanocyclopropane-1,2-dicarboxylates in 50–85% yields. Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 8, pp. 1546–1549, August, 1999.     

Stereoselective electrochemical transformation of 4-substituted cyclohexanones into cis-5-substituted 2,2-dimethoxycyclohexanols

Electrolysis of 4-substituted cyclohexanones in methanol in the presence of sodium halides as mediators in an undivided cell results in the stereoselective formation of cis-5-substituted 2,2-dimethoxycyclohexanols in 70—80% yields.     

Electrocatalytic cascade approach to the synthesis of dihydro-2'H,3H-spiro[1-benzofuran-2,5'-pyrimidines]

Chemistry of Heterocyclic Compounds - Electrocatalytic cascade assembly of benzylidenebarbiturates and cyclohexane-1,3-diones in methanol in the presence of sodium bromide as mediator in an...     

The first example of the cascade assembly of a spirocyclopropane structure: direct transformation of benzylidenemalononitriles and N,N′-dialkylbarbituric acids into substituted 2-aryl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitriles

The direct formation of substituted 2-aryl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitriles in 75-95% yields from benzylidenemalononitriles and N,N′-dialkylbarbituric acids is described.     

Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H‐Pyrano‐[4,3‐b]pyran‐5‐one and 4,6‐Dihydro‐5H‐pyrano‐[3,2‐c]pyridine‐5‐one Scaffolds

The general ‘on‐solvent’ PASE approach was found to be medicinally relevant for 4H,5H‐pyrano[4,3‐b]pyran‐5‐one and 4,6‐dihydro‐5H‐pyrano[3,2‐c]pyridine‐5‐one scaffolds. Ammonium acetate‐catalyzed multicomponent reaction of aldehydes and two different C–H acids in the presence of small amounts of EtOH results in fast (3 – 15 min) and efficient formation of scaffolds, promising for many diverse oriented medical applications.     

Pyridinium bromide as a new mediator for electrochemical transformations involving CH-acids

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Highly diastereoselective four-component synthesis of polysubstituted 2-piperidinones with three and four stereogenic centers

Research on Chemical Intermediates - A novel four-component diastereoselective synthesis of polysubstituted 2-piperidinones is reported. The Michael addition–Mannich cascade of...