17β-雌二醇对血管紧张素Ⅱ诱导的心功能抑制的保护作用及其机制

为探讨17β-雌二醇(E2)对血管紧张素Ⅱ(AngⅡ)诱导的心功能抑制的保护作用及其可能的机制,应用Langendorff灌流装置,将含有AngⅡ,E2+AngⅡ及E2+ICI(182)+AngⅡ的灌流液灌注于离体大鼠心脏,比较心脏收缩功能参数;以差速贴壁法分离并培养乳鼠心肌细胞,用AngⅡ,AngⅡ+E2及AngⅡ+E2+ICI182分别刺激心肌细胞,以MTT法比较各组心肌细胞的增殖情况,并用Western Blotting方法检测p-p38水平.结果表明,雌激素可以改善AngⅡ诱导的心脏收缩舒张功能障碍,抑制AngⅡ诱导的心肌细胞的增殖,其调控机制可能与其干预p38MAPK信号通路的活化有关,雌激素的作用部分是通过其特异性受体实现的.     

N-[2-(1H-吲哚-3)乙基]-2-乙酰噻唑-4-甲酰胺及其类似物的合成

N-[2-(1H-吲哚-3)乙基]-2-乙酰噻唑-4-甲酰胺是最近从海洋细菌中分离得到的一种新型的天然杀藻剂, 以D-丙氨酸为原料合成了该化合物, 并用类似的方法首次合成了它的类似物2, 3和4. 其关键步骤为通过将取代的4-噻唑甲酸制成混酐与色胺连接的偶联反应. 各中间体都通过¹H NMR和¹³C NMR得到证实. 最终产品通过¹H NMR, ¹³C NMR和HRMS证实, 与文献所报道相一致.     

基于时间透镜原理实现微波信号时间反演

时间反演电磁学是一门新兴学科. 高效的电磁时间反演信号获取方式是时间反演技术获得应用的关键. 本文研究了一种基于时域成像原理获得时间反演微波信号的方法. 首先根据时间透镜原理, 推导出了实现波形时间反演的条件, 并对波形反演的过程进行了数值仿真. 然后设计了两种满足反演条件的啁啾电磁带隙结构来构造色散信道, 并通过实验得到了一个时隙长度为1.5 ns的时间反演信号. 由于啁啾电磁带隙结构与理想色散信道的差异, 实验结果中存在波形失真. 文章最后对造成失真的原因进行了分析.     

一类二阶非自治Hamilton系统的周期解

在线性增长和次线性增长条件下,利用临界点理论中的极小作用原理和鞍点定理,研究了二阶非自治Hamilton系统周期解的存在性问题,获得了一些新的可解性条件．     

具有“积分小”系数的中立型方程的振动性

讨论了中立型方程d/(dt)[x(t) - R(t)x(t - r)] + P(t)x(t - τ) - Q(t)x(t - δ) = 0,的振动性,其中P,Q,R∈C（[t₀,∞), R⁺）,r,τ,δ∈（0,∞）,得到若干新结果。     

Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory

Chinese Journal of Polymer Science - The development of biopolymers for biomedical applications has traditionally been based on new chemistries. However, there is growing recognition that the...     

Submanifolds of ℙn(l) with Splitting Tangent Sequence

Acta Mathematica Sinica, English Series - Let l be a line in a projective space ?n. We consider the blowing up ?n(l) of ?n along l. Assume that X is a smooth closed subvariety of...     

Electrostatic Shielding Boosts Electrochemical Performance of Alloy-Type Anode Materials of Sodium-Ion Batteries

The applications of alloy-type anode materials for Na-ion batteries are always obstructed by enormous volume variation upon cycles. Here, K⁺ ions are introduced as an electrolyte additive to improve the electrochemical performance via electrostatic shielding, using Sn microparticles (μ-Sn) as a model. Theoretical calculations and experimental results indicate that K⁺ ions are not incorporated in the electrode, but accumulate on some sites. This accumulation slows down the local sodiation at the “hot spots”, promotes the uniform sodiation and enhances the electrode stability. Therefore, the electrode maintains a high specific capacity of 565 mAh g⁻¹ after 3000 cycles at 2 A g⁻¹, much better than the case without K⁺. The electrode also remains an areal capacity of ≈3.5 mAh cm⁻² after 100 cycles. This method does not involve time-consuming preparation, sophisticated instruments and expensive reagents, exhibiting the promising potential for other anode materials.     

Molecular Simulations in Macromolecular Science

Chinese Journal of Polymer Science - Molecular simulations are now an essential part of modern chemistry and physics, especially for the investigation of macromolecules. They have evolved into...