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101.
Pardasani D Kanaujia PK Gupta AK Tak V Shrivastava RK Dubey DK 《Journal of chromatography. A》2007,1141(2):151-157
Alkylphosphonic acids (APAs), particularly the methyl-, ethyl-, isopropyl- and n-propyl-phosphonic acids are important markers of extremely toxic nerve agents. Hence, their detection and identification is of vital importance to verification of chemical weapons convention (CWC). Verification analysis of CWC requires development of fast, reliable, simple and reproducible sample preparation methods of water and soil samples. Present investigation is focused on the optimization of alkylation of APAs in water with subsequent extraction of alkylated acids by hollow fiber liquid phase microextraction (HF-LPME). This simple and sensitive sample preparation of APAs from water offered better recoveries in comparison to conventionally used extraction technique. Under optimized conditions, the APAs were detected at the concentration of 0.5-0.75 microg/mL with S/N ratio > or = 5, whereas the LODs for alkyl APAs (monobasic APAs) were achieved up to 0.1 microg/mL. The developed method was finally tested with water samples supplied in 19th official proficiency test conducted by the OPCW. 相似文献
102.
103.
Avik Mazumder Hemendra K. Gupta Prabhat Garg Rajeev Jain Devendra K. Dubey 《Journal of chromatography. A》2009,1216(27):5228-5234
This paper details an on-flow liquid chromatography–ultraviolet–nuclear magnetic resonance (LC–UV–NMR) method for the retrospective detection and identification of alkyl alkylphosphonic acids (AAPAs) and alkylphosphonic acids (APAs), the markers of the toxic nerve agents for verification of the Chemical Weapons Convention (CWC). Initially, the LC–UV–NMR parameters were optimized for benzyl derivatives of the APAs and AAPAs. The optimized parameters include stationary phase C18, mobile phase methanol:water 78:22 (v/v), UV detection at 268 nm and 1H NMR acquisition conditions. The protocol described herein allowed the detection of analytes through acquisition of high quality NMR spectra from the aqueous solution of the APAs and AAPAs with high concentrations of interfering background chemicals which have been removed by preceding sample preparation. The reported standard deviation for the quantification is related to the UV detector which showed relative standard deviations (RSDs) for quantification within ±1.1%, while lower limit of detection upto 16 μg (in μg absolute) for the NMR detector. Finally the developed LC–UV–NMR method was applied to identify the APAs and AAPAs in real water samples, consequent to solid phase extraction and derivatization. The method is fast (total experiment time ∼2 h), sensitive, rugged and efficient. 相似文献
104.
Chandan K. Dubey 《Discrete Applied Mathematics》2009,157(1):149-163
An undirected graph G=(V,E) with a specific subset X⊂V is called X-critical if G and G(X), induced subgraph on X, are indecomposable but G(V−{w}) is decomposable for every w∈V−X. This is a generalization of critically indecomposable graphs studied by Schmerl and Trotter [J.H. Schmerl, W.T. Trotter, Critically indecomposable partially ordered sets, graphs, tournaments and other binary relational structures, Discrete Mathematics 113 (1993) 191-205] and Bonizzoni [P. Bonizzoni, Primitive 2-structures with the (n−2)-property, Theoretical Computer Science 132 (1994) 151-178], who deal with the case where X is empty.We present several structural results for this class of graphs and show that in every X-critical graph the vertices of V−X can be partitioned into pairs (a1,b1),(a2,b2),…,(am,bm) such that G(V−{aj1,bj1,…,ajk,bjk}) is also an X-critical graph for arbitrary set of indices {j1,…,jk}. These vertex pairs are called commutative elimination sequence. If G is an arbitrary indecomposable graph with an indecomposable induced subgraph G(X), then the above result establishes the existence of an indecomposability preserving sequence of vertex pairs (x1,y1),…,(xt,yt) such that xi,yi∈V−X. As an application of the commutative elimination sequence of an X-critical graph we present algorithms to extend a 3-coloring (similarly, 1-factor) of G(X) to entire G. 相似文献
105.
J.B. Shukla Shalini Sharma B. Dubey Prawal Sinha 《Nonlinear Analysis: Real World Applications》2009,10(1):54-70
In this paper, a nonlinear mathematical model is proposed and analyzed to study the survival of a resource-dependent population. It is assumed that this population and its resource are affected simultaneously by a toxicant (pollutant) emitted into the environment from external sources as well as formed by precursors of this population. It is shown that as the cumulative rates of emission and formation of the toxicant into the environment increase, the densities of population and its resource settle down to lower equilibria than their initial carrying capacities, and their magnitudes decrease as rates of emission and formation of the toxicant increase. On comparing different cases, it is noted that when population is not affected directly by the toxicant but only its resource is affected, the possibility of its survival is greater than the case when both are affected simultaneously. But for large emission rate of toxicant, the affected resource may be driven to extinction under certain conditions and the population which wholly depends on it may not survive for long even if it is not affected directly by the toxicant. 相似文献
106.
Synthesis of α‐Benzylthiobenzimidazoleacetonitriles and Their Chemoselective Reduction of the Double Bond with NaBH4
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Srinivas Rao Sadhu Chittireddy Venkata Ramana Reddy Pramod Kumar Dubey 《Journal of heterocyclic chemistry》2016,53(1):74-79
Condensation of 2‐((1H‐benzimidazol‐2‐yl)thio)acetonitre 1 with aromatic aldehydes in methanol containing piperidine gave the corresponding 2‐((1H‐benzimidazol‐2‐yl)thio)‐3‐arylacrylonitrile 2 , which on treatment with NaBH4 in ethanol unexpectedly and chemoselectively gave 2‐((1H‐benzimidazol‐2‐yl)thio)‐3‐arylpropanenitrile 3 by the reduction of the double bond of 2 . 3 on methylation with dimethyl sulfate containing K2CO3 as a base and tetrabutylammonium bromide as PTC gave 2‐((1‐methylbenzimidazol‐2‐yl)thio)‐3‐arylpropanenitrile 6 . The latter could also be prepared in an alternative way by reaction of 1 with dimethyl sulfate giving the intermediary 2‐((1‐methylbenzimidazol‐2‐yl)thio)acetonitrile 4 , followed by condensation with aromatic aldehydes yielding 5 and subsequent reduction of 5 with NaBH4 in methanol. 6 could be directly synthesized by treatment of 4 with benzyl chloride in DMF and triethylamine as a base at 60°C for 5 h. 相似文献
107.
G. Anuradha G. Vasuki G. Surendrareddy A. Veerareddy P. K. Dubey 《Crystallography Reports》2014,59(4):527-535
The title compound 5-bromo-1-(2-cyano-pyridin-4-yl)-1H-indazole-3-carboxylic acid diethylamide, C18H16BrN5O, is prepared from 5-bromoindazole-3-carboxylic acid methylester. N 1-arylation is carried out with 4-chloro-2-cyanopyridine and the resulting product is converted to diethylamide by reacting with thionyl chloride and diethylamine. The structure is identified from its FT-IR, 1H NMR, 13C NMR spectroscopy, elemental analysis data and unambiguously confirmed by single crystal X-ray diffraction studies. There are two symmetry independent molecules in the asymmetric unit with no significant differences in bond lengths and angles. The title compound crystallizes in the triclinic system, space group \(P\bar 1\) , with a = 11.2330(2); b = 11.6130(2); c = 15.4710(3) Å, α = 92.515(1)°; β = 109.956(1)°; γ = 107.199(1)°; V = 1788.45(6)Å3 and z = 4. An intramolecular C-H…N hydrogen bond forms an S(6) ring motif in one of the unique molecules. In the crystal, two molecules are linked about a center of inversion by C-H…O hydrogen bonded dimers generating an R 2 2 (16) ring motif. The crystal packing is stabilized by C-H…N, C-H…O hydrogen bonds and π…π stacking interactions. 相似文献
108.
Ionic liquid catalyzed synthesis of 7-phenyl-1,4,6,7-tetrahydro-thiazolo[5,4-d]pyrimidine-2,5-diones
Prashant Singh Kamlesh Kumari Monica Dubey Vijay K. Vishvakarma Gopal K. Mehrotra Narender D. Pandey Ramesh Chandra 《Comptes Rendus Chimie》2012,15(6):504-510
A simple, green and catalyst free one pot synthesis of 7-phenyl-1,4,6,7-tetrahydro-thiazolo[5,4-d]pyrimidine-2,5-diones via a multicomponent reaction between thiazolidine-2, 4-dione (TZD), aromatic aldehyde and urea analogues is described. The ionic liquid has been used as a solvent as well as catalyst for this reaction. This reaction proceeded smoothly in good to excellent yields and offered several other advantages including short reaction time, simple experimental workup procedure and no by-products. 相似文献
109.
Weidner T Dubey M Breen NF Ash J Baio JE Jaye C Fischer DA Drobny GP Castner DG 《Journal of the American Chemical Society》2012,134(21):8750-8753
Extracellular biomineralization proteins such as salivary statherin control the growth of hydroxyapatite (HAP), the principal component of teeth and bones. Despite the important role that statherin plays in the regulation of hard tissue formation in humans, the surface recognition mechanisms involved are poorly understood. The protein-surface interaction likely involves very specific contacts between the surface atoms and the key protein side chains. This study demonstrates for the first time the power of combining near-edge X-ray absorption fine structure (NEXAFS) spectroscopy with element labeling to quantify the orientation of individual side chains. In this work, the 15 amino acid N-terminal binding domain of statherin has been adsorbed onto HAP surfaces, and the orientations of phenylalanine rings F7 and F14 have been determined using NEXAFS analysis and fluorine labels at individual phenylalanine sites. The NEXAFS-derived phenylalanine tilt angles have been verified with sum frequency generation spectroscopy. 相似文献
110.
Debamitra Chakravorty Saravanan Parameswaran Vikash Kumar Dubey Sanjukta Patra 《Applied biochemistry and biotechnology》2012,167(3):439-461
Organic solvent-stable lipases have pronounced impact on industrial economy as they are involved in synthesis by esterification, interesterification, and transesterification. However, very few of such natural lipases have been isolated till date. A study of the recent past provided few pillars to rely on for this work. The three-dimensional structure, inclusive of the surface and active site, of 29 organic solvent-stable lipases was analyzed by subfamily classification and protein solvent molecular docking based on fast Fourier transform correlation approach. The observations revealed that organic solvent stability of lipases is their intrinsic property and unique with respect to each lipase. In this paper, factors like surface distribution of charged, hydrophobic, and neutral residues, interaction of solvents with catalytically immutable residues, and residues interacting with essential water molecules required for lipase activity, synergistically and by mutualism contribute to render a stable lipase organic solvent. The propensity of surface charge in relation to stability in organic solvents by establishing repulsive forces to exclude solvent molecules from interacting with the surface and prohibiting the same from gaining entry to the protein core, thus stabilizing the active conformation, is a new finding. It was also interesting to note that lipases having equivalent surface-exposed positive and negative residues were stable in a wide range of organic solvents, irrespective of their LogP values. 相似文献