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981.
纸基生物传感器由于其具有成本低、操作方便、生物可降解、识别元件用量低等优点,近年来受到了广泛的关注。其中,以功能核酸作为识别元件的纸基荧光生物传感器具有较高的灵敏度、瞬时响应以及实时检测等特性,在便携式传感设备方面展现出巨大的潜力。此外,将核酸作为识别元件的纸基无细胞蛋白合成平台,通过条件合成的报告荧光蛋白可实现对病毒、重金属等目标物的特异性检测,具有良好的应用前景。首先,本文介绍了基于核酸的纸基荧光生物传感器的设计,特别是基于核酸的识别元件与纸基材料的结合方式。其次,总结了基于核酸的纸基荧光生物传感器在临床诊断、食品安全检测、环境污染物检测等不同领域的最新研究进展,讨论了其优势与局限性。最后,探讨了基于核酸的纸基荧光生物传感器的发展方向与应用前景,以期为相关领域的研究提供参考。 相似文献
982.
Hua Lei Meixuan Wu Ying Liu Fan Mo Jiayao Chen Shilong Ji Yan Zou Xiaoping Dong 《中国化学快报》2021,32(7):2317-2321
Photocatalysis technology has been proved to be a potential strategy for removal of organic dyes, however high-power light sources are generally necessary to initiate photocatalytic reaction. In this work, we employed an excellent photocatalyst of Bi2WO6 with visible light harvest and meanwhile an intrinsic ferroelectricity, which realized the efficient degradation of organic dye via the synergetic photopiezocatalysis. Through coupling the illumination by a low-power (9 W) LED and the ultrasonic vibration (120 W) by an ultrasonic cleaner, the nanoflower-like Bi2WO6 composed of ultrathin nanosheets showed a much more enhanced photopiezocatalysis performance for purification of organic dye than the individual photocatalysis and piezocatalysis. Furthermore, the high mineralization efficiency and the good durability of the Bi2WO6 catalyst were demonstrated. The possible mechanism of photopiezocatalysis was finally proposed, where the ultrasound-induced piezoelectric field in Bi2WO6 drove photo-generated electrons and holes to diffuse along opposite directions, consequently promoting the separation efficiency of charge carriers. This work indicates that the synergetic photopiezocatalysis by coupling irradiation and ultrasonic vibration is a promising strategy to purify organic pollutants in wastewater. 相似文献
983.
984.
985.
Lingli Lei Yuanyuan Zhang Ying Jiang Lulu Xiong Yingshuai Liu Chang Ming Li 《Electroanalysis》2021,33(10):2180-2186
Biomimetic electrochemical sensors are very promising not only due to their lower expense and longer stability than conventional enzymatic ones, but they also often suffer from simultaneously achieving high sensitivity and good selectivity. Here we present a well-defined Au@Co3O4/CeO2 yolk-shell nanostructure (YSN) that is first synthesized and exploited as highly efficient electrocatalysts for hydrogen peroxide (H2O2) detection. The introduced CeO2 in Co3O4 matrix greatly facilitates the migration of lattice oxygen, which increases the concentration of surface oxygen vacancies (Oa), remarkably enhancing the adsorption ability of H2O2 and promoting the decomposition of H2O2 for faster electron transfer than pristine Au@Co3O4 core-shell nanostructure (CSN). The abundant Oa of Au@Co3O4/CeO2 YSN is confirmed by X-ray photoelectron spectroscopy (XPS) and electron paramagnetic resonance (EPR). The as-prepared biomimetic sensor delivers a wide dynamic range (5.0 nM to 5.4 μM), a low limit of detection (LOD) (2.74 nM), and a high sensitivity (35.67 μA μM−1 cm−2), paving a new way to construct an ultrasensitive and selective enzyme-free biomimetic electrochemical sensor. Furthermore, the sensor is used to real-time monitor H2O2 released from human cervical cancer cells (HeLa) and human umbilical vein endothelial cells (HUVEC), demonstrating its great potential in practical applications. 相似文献
986.
Xiaoya Wang Bingbing Liu Jie Li Yunyun Zhai Haiqing Liu Lei Li Herui Wen 《Electroanalysis》2021,33(6):1484-1490
2D metal-organic framework (MOF) has potential applications in electrocatalysis owing to fast mass transfer, charge transfer and large specific surface area. Here, we had prepared three conductive 2D MOF based on Ni, NiCo and Co in a simple and rapid way. The 2D nanostructure of MOF was confirmed by SEM and TEM. The chemical composition was studied by XRD, Raman and XPS spectrum. The electrochemical oxidation and detection was investigated through cyclic voltammetry and current-time method. Their sensing performance for urea was determined by varying oxidation potentials and metal sites. The non-enzymatic Ni-, NiCo- and Co-MOF sensors had good catalytic activity for urea. Compared with NiCo- and Co-MOF, Ni-MOF had a wider linear range (0.5–832.5 μM), high sensitivity (1960 μA mM−1 cm−2), low detection limit (0.471 μM), and fast response time. The sensors had well repeatability, reproducibility, and selectivity to specific interfering species. Furthermore, Ni- and NiCo-MOF modified electrode was also applied to detection of milk samples. The results showed that the recovery was satisfactory, which further confirmed the effectiveness of non-enzyme sensor. In general, the highly-sensitive 2D Ni- and NiCo-MOF modified electrode has great potential as nonenzymatic urea sensors for real samples detection in hydrogen energy, clinical diagnostics, and environmental protection, et al. 相似文献
987.
Hao Xu Jie Zhu Xiong Wang Chao Shen Shengshen Meng Kai Zheng Chao Lei Longfeng Zhu 《Molecules (Basel, Switzerland)》2021,26(5)
Developing sustainable routes for the synthesis of zeolites is still a vital and challenging task in zeolite scientific community. One of the typical examples is sustainable synthesis of aluminosilicate EU-1 zeolite, which is not very efficient and environmental-unfriendly under hydrothermal condition due to the use of a large amount of water as solvent. Herein, we report a sustainable synthesis route for aluminosilicate EU-1 zeolite without the use of solvent for the first time. The physicochemical properties of the obtained EU-1 zeolite are characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetry-differential thermal analysis (TG-DTA), N2 sorption, inductively coupled plasma (ICP) analysis, and solid nuclear magnetic resonance (NMR), which show the product has high crystallinity, uniform morphology, large BET surface area, and four-coordinated aluminum species. Moreover, the impact of synthesis conditions is investigated in detail. The sustainable synthesis of aluminosilicate EU-1 zeolite under solvent-free 相似文献
988.
Shukun Wei Xiaoyou Hu Lingyu Du Linlin Zhao Hongjuan Xue Chaolun Liu James J. Chou Jin Zhong Yimin Tong Shuqing Wang Bo OuYang 《Molecules (Basel, Switzerland)》2021,26(5)
Hepatitis C Virus (HCV) is the key cause of chronic and severe liver diseases. The recent direct-acting antiviral agents have shown the clinical success on HCV-related diseases, but the rapid HCV mutations of the virus highlight the sustaining necessity to develop new drugs. p7, the viroporin protein from HCV, has been sought after as a potential anti-HCV drug target. Several classes of compounds, such as amantadine and rimantadine have been testified for p7 inhibition. However, the efficacies of these compounds are not high. Here, we screened some novel p7 inhibitors with amantadine scaffold for the inhibitor development. The dissociation constant (Kd) of 42 ARD-series compounds were determined by nuclear magnetic resonance (NMR) titrations. The efficacies of the two best inhibitors, ARD87 and ARD112, were further confirmed using viral production assay. The binding mode analysis and binding stability for the strongest inhibitor were deciphered by molecular dynamics (MD) simulation. These ARD-series compounds together with 49 previously published compounds were further analyzed by molecular docking. Key pharmacophores were identified among the structure-similar compounds. Our studies suggest that different functional groups are highly correlated with the efficacy for inhibiting p7 of HCV, in which hydrophobic interactions are the dominant forces for the inhibition potency. Our findings provide guiding principles for designing higher affinity inhibitors of p7 as potential anti-HCV drug candidates. 相似文献
989.
本文结合分子动力学方法和动力学蒙特卡罗方法, 研究了单个粒子入射硅引起的位移损伤缺陷的产生和演化过程; 基于Shockley-Read-Hall理论计算了单个粒子入射引起的位移损伤缺陷导致的泄漏电流增加及其演化过程, 比较了缺陷退火因子与泄漏电流退火因子之间的差异, 并将计算结果与实验值进行了对比. 结果表明, 计算泄漏电流时, 仅考虑一种缺陷的情况下缺陷退火因子与泄漏电流退火因子相同, 考虑两种缺陷类型情况下二者在数值上有所区别, 但缺陷退火因子仍能在一定程度上反映泄漏电流的退火行为. 分子动力学模拟中采用Stillinger-Weber势函数和Tersoff势函数时缺陷退火因子和泄漏电流退火因子与实验结果一致, 基于Stillinger-Weber势函数的计算结果与实验值更为接近. 相似文献
990.
Jin FangZhou Chen HongWei Rong Xing Zhou Hui Shi MingJun Zhang Qi Ju ChenYong Cai YiFu Luo ShunLong Peng XinHua Du JiangFeng 《中国科学:物理学 力学 天文学(英文版)》2016,59(3):1-7
A triad mode resonance, or three-wave resonance, is typical of dynamical systems with quadratic nonlinearities. Suspended cables are found to be rich in triad mode resonant dynamics. In this paper, modulation equations for cable’s triad resonance are formulated by the multiple scale method. Dynamic conservative quantities, i.e., mode energy and Manley-Rowe relations, are then constructed. Equilibrium/dynamic solutions of the modulation equations are obtained, and full investigations into their stability and bifurcation characteristics are presented. Various bifurcation behaviors are detected in cable’s triad resonant responses, such as saddle-node, Hopf, pitchfork and period-doubling bifurcations. Nonlinear behaviors, like jump and saturation phenomena, are also found in cable’s responses. Based upon the bifurcation analysis, two interesting properties associated with activation of cable’s triad resonance are also proposed, i.e., energy barrier and directional dependence. The first gives the critical amplitude of high-frequency mode to activate cable’s triad resonance, and the second characterizes the degree of difficulty for activating cable’s triad resonance in two opposite directions, i.e., with positive or negative internal detuning parameter. 相似文献