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The alum-borneol nanoemulsion(ABN), which combines the mineral medicine alum and the botanical medicine borneol, has been applied for approximately 40 years in the clinical treatment of burns, scalds, radiation dermatitis and shingles, and has a good curative effect. However, the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation, which greatly affects the efficacy of the drug. In this study, polyvinylpyrrolidone(PVP) was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF) by electrospinning. The results showed that the stable system with good drug dispersion was 2:3(alum:borneol). The dissolution content of borneol from the ABPF was about 80% in 4 h, which was much higher than that of the alum-borneol liquid(ABL) and ABN. The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN. The composite fiber markedly increased the drug content of borneol, which was 800 times of that in ABN. The fiber had a higher solubility than the nanoemulsion in vitro, which is of great importance for the de-velopment of new forms for the clinical application of alum and borneol. 相似文献
23.
实验室中水声材料声学参数的测量主要在水声声管中进行。管内平面波声速是正确测量这些参数的基础。该文提出一种基于四水听器结合不同边界的测量充水弹性管中声速的新方法。该方法利用4个固定位置处的水听器,采用最小二乘的方法,使得两组水听器分别得到的声管末端入射波声压差值的平方最小的声速即为管内平面波声速。该方法利用单频信号,在每一频率点均可测得声速,可以在任一种声管末端边界下进行测量,同时无需知道各水听器到边界的精确距离,在文中的3种边界下声速测量结果具有很好的一致性,实验操作简单、误差很小。该方法的仿真结果与管内声速的理论值吻合得很好,同时实验测量结果与仿真值之间的误差很小,证明了方法的准确性以及鲁棒性,为声管声速测量提供一个很好的思路。 相似文献
24.
Jian Li Guangrui Chen Zhiyun Meng Zhuona Wu Hui Gan Xiaoxia Zhu Peng Han Taoyun Liu Fanjun Wang Ruolan Gu Guifang Dou 《Molecules (Basel, Switzerland)》2022,27(9)
Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. However, its application is challenged by its poor dissolubility and oral bioavailability. The present study aimed to improve the bioavailability of CEP by optimizing its solubility and through a pulmonary delivery method, which improved its bioavailability by five times when compared to that through the oral delivery method (68.07% vs. 13.15%). An ultra-performance liquid chromatography tandem-mass spectrometry (UPLC-MS/MS) method for quantification of CEP in rat plasma was developed and validated to support the bioavailability and pharmacokinetic studies. In addition, pulmonary fibrosis was recognized as a sequela of COVID-19 infection, warranting further evaluation of the therapeutic potential of CEP on a rat lung fibrosis model. The antifibrotic effect was assessed by analysis of lung index and histopathological examination, detection of transforming growth factor (TGF)-β1, interleukin-6 (IL-6), α-smooth muscle actin (α-SMA), and hydroxyproline level in serum or lung tissues. Our data demonstrated that CEP could significantly alleviate bleomycin (BLM)-induced collagen accumulation and inflammation, thereby exerting protective effects against pulmonary fibrosis. Our results provide evidence supporting the hypothesis that pulmonary delivery CEP may be a promising therapy for pulmonary fibrosis associated with COVID-19 infection. 相似文献
25.
压电加速度传感器是同振型矢量水听器的核心部件。为了满足低频高灵敏度矢量水听器的应用需求,提出并研究一种具有层合梁结构的低频高灵敏度加速度传感器。结合弹性力学和压电方程推导层合梁加速度传感器的加速度灵敏度解析解表达式,通过有限元仿真对层合梁加速度传感器尺寸进行优化,给出优化后的尺寸范围。从优化的尺寸范围中选取两种不同尺寸进行加速度传感器振动特性的仿真分析及实物制作(其中压电材料为PZT-5)与性能测试。仿真与测试结果均表明,相比已有的同尺寸金属梁加速度传感器,层合梁加速度传感器可以有效降低谐振频率并提升加速度灵敏度。当压电层厚度为0.5 mm时,加速度灵敏度最大提升3.9 dB,谐振频率下降23%。测试结果与理论分析相符。 相似文献
26.
Henri J.-M. Dou Parina Hassanaly Jacky Kister Jacques Metzger 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):355-358
Abstract Alkylation via phase transfer catalysis of several ambident anions of the |N–C–S|? type leads exclusively to S-substitution. Yields obtained are better or equal to those given by conventional methods and experimental work-up is very much simplified compared to the latter. 相似文献
27.
Based on quantum chemistry calculations combined with the Marcus–Hush electron transfer theory, we investigated the charge‐transport properties of oligothiophenes (nTs) and oligopyrroles (nPs) (n=6, 7, 8) as potential p‐ or n‐type organic semiconductor materials. The results of our calculations indicate that 1) the nPs show intrinsic hole mobilities as high as or even higher than those of nTs, and 2) the vertical ionization potentials (VIPs) of the nPs are about 0.6–0.7 eV smaller than the corresponding VIPs of the nTs. Based on their charge‐transport ability and hole‐injection efficiency, the nPs have potential as p‐type organic semiconducting materials. Furthermore, it was also found that the maximum values of the electron‐transfer mobility for the nTs are larger by one‐to‐two orders of magnitude than the corresponding maximum values of hole‐transfer mobility, which suggests that the nTs have the potential to be developed as promising n‐type organic semiconducting materials owing to their electron mobility. 相似文献
28.
Advances in pesticide biosensors: current status, challenges, and future perspectives 总被引:1,自引:0,他引:1
Public concern over pesticide residues has been increasing dramatically owing to the high toxicity and bioaccumulation effects of pesticides and the serious risks that they pose to the environment and human health. It is therefore crucial to monitor pesticide residues by using various analytical methods and techniques, especially highly sensitive, highly selective, simple, rapid, cost-effective, and portable ones. Biosensor strategies have become research hotspots and ideal candidates for pesticide detection, having such features as high sensitivity, fast response, robustness, low cost and miniaturization, as well as in situ and real-time monitoring. This review covers advances in the design and fabrication of biosensors for pesticide detection since 2005. Special emphasis is placed on the state-of-art selection of receptors, the use of different transduction techniques and fast screening strategies, and the application of various biosensors developed in food and environmental safety. Both advantages and drawbacks of these techniques are then summarized. Finally, challenges, strategies, and perspectives in further developing pesticide biosensors are also discussed. Figure
Principle of operation of pesticide biosensors 相似文献
29.
We have developed a simple and efficient method for dispersive liquid-liquid microextraction of 4-nitrophenol, 2-naphthol and bisphenol A in real water samples. It is making use of solidified floating organic droplets of 1-dodecanol which has low density and a proper melting point. The type and volume of extraction solvent and dispersive solvent, the effect of salts, pH value and extraction time were optimized and resulted in enrichment factors of 84 for 4-nitrophenol, 123 for 2-naphthol, and 97 for bisphenol A. The limits of detection by HPLC are 1.50, 0.10 and 1.02 ng · mL?1, respectively. Excellent linearity is observed in the concentration range from 10 to 800 ng · mL?1, with coefficients of correlation ranging from 0.9988 to 0.9999. The relative standard deviations (for n?=?5) are from 3.2 to 5.3 %, and relative recoveries for the three phenols in tap, river and spring water range from 85.0 to 105.0 %, 98.3 to 110.0 %, and 98.6 to 109.0 %, respectively. Figure
Chromatograms of river water blank (b) and spiked river water (a, 500 ng ? mL?1) analyzed with DLLME-SFO-HPLC. Peak identification: (1) p-nitrophenol; (2) 2-naphthol; (3) bisphenol A. Liquid-liquid microextraction method based on solidification of floating organic droplet (DLLME-SFO) has a high enrichment factor (84, 123and 97), acceptable relative recovery (85.0 %–110.0 %), good repeatability (5.27 %, 3.54 % and 3.16 %) and a wide linear range (10–800 ng · mL?1) for the determination of p-nitrophenol, 2-naphthol and bisphenol A. 相似文献
30.
Shamsa Kanwal Qiang Ma Wenchao Dou Guannan Wang 《International journal of environmental analytical chemistry》2013,93(2):210-221
A new sensitive chemiluminescence (CL) method combined with continuous flow injection analysis is described for the determination of Cr(VI). Strong CL signals were generated by Cr(VI)-catalysed oxidation of gallic acid in the presence of potassium permanganate and hydrogen peroxide. Effects of reagent concentrations, temperature, pH, flow rates, mixing coil length and mixing flow sequences on the chemiluminescence intensity were studied. Under the optimised experimental conditions, the relationship between the logarithm of concentration (log?C) of Cr(VI) and the logarithm of intensity (log?I) is linear over the range of 2?×?10?11 – 5?×?10?4?mol?L?1, with the detection limit (3σ) of 4?×?10?12?mol?L?1. Relative standard deviation of ten measurements of 1?×?10?9?mol?L?1 Cr(VI) is 1.7%. This flow injection analysis (FIA) system proved to be able to analyse up to 40 samples h?1. Effects of various interferences possibly present in the water samples were investigated. Most cations and anions, as well as organic compounds, did not interfere with the determination of Cr(VI) in water samples. The experimental results obtained for chromium in reference materials were also in good agreement with the certified values. 相似文献