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981.
982.
983.
Jung IH Lee YH Yoo JY Jeong SJ Sonn SK Park JG Ryu KH Lee BY Han HY Lee SY Kim DY Lee H Oh GT 《Experimental & molecular medicine》2012,44(5):311-318
In this study, the synergistic effect of 6-[4-(1-cyclohexyl- 1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H )-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and adhesion molecules such as monocyte chemoattractant-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and VCAM-1 which can initiate atherosclerosis were significantly reduced by the co-treatment of cilostazol with GbE. Further, the infiltration of macrophages into the intima was decreased by co-treatment. These results suggest that co-treatment of GbE with cilostazol has a more potent anti-atherosclerotic effect than treatment with cilostazol alone in hyperlipidemic ApoE null mice and could be a valuable therapeutic strategy for the treatment of atherosclerosis. 相似文献
984.
We demonstrate the self-assembly of tripeptide amphiphiles into spherical hollow capsules from linear nanoribbons via control of the molecular packing. We achieved a transition of arrangement from anisotropic to isotropic by an elaborate design of the molecular architecture. 相似文献
985.
Kobayashi S Inoue T Ando A Tamanoi H Ryu I Masuyama A 《The Journal of organic chemistry》2012,77(13):5819-5822
The total synthesis of hericerin, a pollen growth inhibitor from Hericium erinaceum, was achieved. We found that the reported structure of hericerin should be revised to be the carbonyl regioisomer. 相似文献
986.
987.
Goluch ED Nam JM Georganopoulou DG Chiesl TN Shaikh KA Ryu KS Barron AE Mirkin CA Liu C 《Lab on a chip》2006,6(10):1293-1299
Functionalized nanoparticles hold great promise in realizing highly sensitive and selective biodetection. We report a single disposable chip which is capable of carrying out a multi-step process that employs nanoparticles--a bio-barcode assay (BCA) for single protein marker detection. To illustrate the capability of the system, we tested for the presence of prostate specific antigen (PSA) in buffer solution and goat serum. Detection was accomplished at PSA concentrations as low as 500 aM. This corresponds to only 300 copies of protein analytes using 1 microL total sample volume. We established that the on-chip BCA for PSA detection offers four orders of magnitude higher sensitivity compared to commercially available ELISA-based PSA tests. 相似文献
988.
Choi SK Oh HM Lee SK Jeong DG Ryu SE Son KH Han DC Sung ND Baek NI Kwon BM 《Natural product research》2006,20(4):341-346
Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 microM, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources. 相似文献
989.
Stereoselective synthesis of novel 1'-alpha-substituted-4'-thionucleosides was achieved starting from D-gulonic acid gamma-lactone via stereoselective nucleophilic substitution. 相似文献
990.
Lim B Hwang JT Kim JY Ghim J Vak D Noh YY Lee SH Lee K Heeger AJ Kim DY 《Organic letters》2006,8(21):4703-4706
[reaction: see text] A new curable arylamine containing a perfluorocyclobutane (PFCB) structure without an acidic group was synthesized. The material was thermally cured on ITO after spin-coating. The polymer showed excellent solvent resistance, high thermal stability, high transparency, and good surface smoothness. 相似文献