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排序方式: 共有165条查询结果,搜索用时 31 毫秒
131.
Mark A. Bailey Matthew J. Ingram Declan P. Naughton Ken J. Rutt Howard T. Dodd 《Transition Metal Chemistry》2008,33(2):195-202
Aminosalicylic acids have been used to combat inflammatory bowel diseases (IBDs) for over 60 years. In this report, spectroscopic
studies on the Cu(II) complexation behaviour of the newly synthesised chelator ethylenediaminetetraacetic acid bis-(4-aminosalicylic
acid methyl ester) (4-EBAME), and the regiostereoisomer ethylenediaminetetraacetic acid bis-(5-aminosalicylic acid methyl
ester) (5-EBAME) are presented. Both conjugates bind to Cu(II) in an ideal 1:1 ratio, as shown by Job’s method and spectroscopic
titrations. 5-EBAME was screened in the NCI 60 cancer cell-line and showed anti-cancer properties. Neither of the conjugates
were degraded by bovine liver protease, although some de-esterification was seen at high pH over a 24-h period. These two
conjugates show potential as metal chelating anti-oxidants for use against IBDs. 相似文献
132.
Swanick KN Dodd DW Price JT Brazeau AL Jones ND Hudson RH Ding Z 《Physical chemistry chemical physics : PCCP》2011,13(38):17405-17412
Triazole-modified deoxycytidines have been prepared for incorporation into single-stranded deoxyribonucleic acid (ssDNA). Electrochemical responses and electrogenerated chemiluminescence (ECL) of these deoxycytidine (dC) analogues, 1-4, were investigated as the monomers. Cyclic voltammetry and differential pulse voltammetry techniques were used to determine the oxidation and reduction potentials of 1-4, along with the reversibility of their electrochemical reactions. The dC analogues, in N,N-dimethylformamide containing 0.1 M tetra-n-butylammonium perchlorate as electrolyte, exhibited weak relative ECL efficiencies following the annihilation mechanism, while these efficiencies were enhanced with the use of benzoyl peroxide following the coreactant mechanism. It was shown that these nucleosides could generate excited monomers, and excimers as seen by the red-shifted ECL maxima relative to their corresponding photoluminescence peak wavelengths. 相似文献
133.
A mathematical model is proposed for the process of vacuum superplasticforming. The model exploits the fact that in most industrialapplications the sheet aspect ratio (thickness/sheet width)is small. After an initial consideration of some of the moregeneral properties and the literature of superplastic materials,the elastic/plastic deformation of an internally-inflated thin-walledcylinder is examined. Plates of arbitrary geometry are thenconsidered. A quasisteady model in which the sheet moves througha sequence of steady states is developed. Some simplified closed-formsolutions are examined, but for general cases a system of nonlinearpartial differential equations must be solved numerically. Anefficient and accurate semi-explicit numerical scheme is proposedand a simplified stability analysis is presented; the methodis then used to compute properties of superplastic vacuum mouldedsheets in a number of practically motivated cases. 相似文献
134.
Alexandre Hentz Dr. Pascal Retailleau Prof. Dr. Vincent Gandon Dr. Kevin Cariou Dr. Robert H. Dodd 《Angewandte Chemie (International ed. in English)》2014,53(32):8333-8337
Two unprecedented N functionalizations of indoles with ynamides are described. By varying the electron‐withdrawing group on the ynamide nitrogen atom, either Z‐indolo‐etheneamides or indolo‐amidines can be selectively obtained under the same metal‐free reaction conditions. The scope and synthetic potential of these reactions, as well as some mechanistic insights provided by DFT calculations, are reported. 相似文献
135.
Ronan Gealageas Natalia P. Malikova Sandrine Picaud Aren J. Borgdorff Ludmila P. Burakova Philippe Brûlet Eugene S. Vysotski Robert H. Dodd 《Analytical and bioanalytical chemistry》2014,406(11):2695-2707
The main analytical use of Ca2+-regulated photoproteins from luminous coelenterates is for real-time non-invasive visualization of intracellular calcium concentration ([Ca2+]i) dynamics in cells and whole organisms. A limitation of this approach for in vivo deep tissue imaging is the fact that blue light emitted by the photoprotein is highly absorbed by tissue. Seven novel coelenterazine analogues were synthesized and their effects on the bioluminescent properties of recombinant obelin from Obelia longissima and aequorin from Aequorea victoria were evaluated. Only analogues having electron-donating groups (m-OCH3 and m-OH) on the C6 phenol moiety or an extended resonance system at the C8 position (1-naphthyl and α-styryl analogues) showed a significant red shift of light emission. Of these, only the α-styryl analogue displayed a sufficiently high light intensity to allow eventual tissue penetration. The possible suitability of this compound for in vivo assays was corroborated by studies with aequorin which allowed the monitoring of [Ca2+]i dynamics in cultured CHO cells and in hippocampal brain slices. Thus, the α-styryl coelenterazine analogue might be potentially useful for non-invasive, in vivo bioluminescence imaging in deep tissues of small animals. 相似文献
136.
137.
A. Scott Dodd 《Fresenius' Journal of Analytical Chemistry》1932,89(5-6):230-232
Ohne Zusammenfassung 相似文献
138.
I.G. Bearden H. Bøggild J. Boissevain P.H.L. Christiansen L. Conin J. Dodd B. Erazmus S. Esumi C.W. Fabjan D. Ferenc A. Franz J.J. Gaardhøje A.G. Hansen O. Hansen D. Hardtke H. van Hecke E.B. Holzer T.J. Humanic P. Hummel B.V. Jacak K. Kaimi M. Kaneta T. Kohama M. Kopytine M. Leltchouk A. Ljubičić Jr. B. Lörstad L. Martin A. Medvedev M. Murray H. Ohnishi G. Paić S.U. Pandey F. Piuz J. Pluta V. Polychronakos M. Potekhin G. Poulard D. Reichhold A. Sakaguchi J. Schmidt-Sørensen J. Simon-Gillo W. Sondheim T. Sugitate J.P. Sullivan Y. Sumi W.J. Willis K. Wolf N. Xu D.S. Zachary 《The European Physical Journal C - Particles and Fields》2002,23(2):237-247
Proton and deuteron production has been observed in S+S and S+Pb collisions at 200 AGeV and in Pb+Pb reactions at 158 AGeV at the CERN SPS accelerator. For Pb+Pb triton production was also measured. The p and d spectra as well as the p and t
spectra were observed in similar rapidity ranges and over similar ranges of transverse momenta per nucleon, making it possible
to interpret the cross sections of the composite particles in terms of coalescence mechanisms. Volumes of homogeneity were
extracted and compared to pion-pair HBT interferometry results. Special attention is given to the dependence on transverse
mass, centrality and rapidity.
Received: 23 July 2001 / Revised version: 16 November 2001 / Published online: 25 January 2002 相似文献
139.
Dodd K Morton D Worden S Narquizian R Nelson A 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(20):5857-5861
The desymmetrisation of centrosymmetric molecules by enantioselective carbon-carbon bond formation has been reported for the first time. A bimetallic zinc catalyst developed by Trost was exploited in the desymmetrisation of a centrosymmetric dialdehyde. The approach was successful with a range of ketone nucleophiles and was uniformly highly diastereoselective (>98:<2). The yield and the enantioselectivity of the reaction varied as a function of the ketone used, and the desymmetrised products were obtained in up to 74 % yield and 97 % ee (ee=enantiomeric excess). The desymmetrisation of centrosymmetric molecules by enantioselective carbon-carbon bond formation is an efficient and convergent synthetic approach which is likely to find wide application in synthesis, particularly in the total synthesis of natural products with embedded centrosymmetric fragments. 相似文献
140.