Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine

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Synthesis and characterization of oxidized cellulose

Samples of oxidized cellulose (OC) with various carboxyl contents and degrees of crystallinity were obtained by the oxidation of native and mercerized cellulose with a solution of nitrogen(IV) oxide in CCl₄. A detailed characterization of these OC samples was performed. The effect of oxidation conditions (concentration of N₂O₄ in the solution and oxidation time) and starting cellulose material on OC characteristics (carboxyl, carbonyl and nitrogen content, degree of crystallinity and polymerization, surface area and swelling, and acidic properties) was investigated. Reactivity in the oxidation process was higher in mercerized cellulose than in native cellulose. The action of dilute solutions (10–15%) of N₂O₄ did not affect the degree of crystallinity of cellulose samples. Under these conditions, the oxidation took place mainly in amorphous regions and on the surface of crystallites. Oxidation in a concentrated (40%) N₂O₄ solution led to the destruction of crystallites, which increased the surface area and swelling of cellulose in water. The surface area and the swelling of OC samples increased with a decrease in the index of crystallinity. The acidic properties of OC were shown to increase with an increase of swelling in water. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 4785–4791, 2004     

Branched Star-Type Polysilyllithium Compounds: The Effects of beta-Silyl Substitution and of Complexation on Their Molecular Structure

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Finite jet determination of local analytic CR automorphisms and their parametrization by 2-jets in the finite type case

We show that germs of local real-analytic CR automorphisms of a real-analytic hypersurface M in $\mathbb{C}$² at a point p M are uniquelydetermined by their jets of some finite order at p if and only if M is not Levi-flat near p. This seems to be the first necessary and sufficient result on finite jet determination and the first result of this kind in the infinite type case.If M is of finite type at p, we prove a stronger assertion: the local real-analytic CR automorphisms of M fixing p are analytically parametrized (and hence uniquely determined) by their 2-jets at p. This result is optimal since the automorphisms of the unit sphere are not determined by their 1-jets at a point of the sphere. The finite type condition is necessary since otherwise the needed jet order can be arbitrarily high [Kow1,2], [Z2]. Moreover, we show, by an example, that determination by 2-jets fails for finite type hypersurfaces already in $\mathbb{C)$³.We also give an application to the dynamics of germs of local biholomorphisms of $\mathbb{C)$².     

A Law of Large Numbers for the Zeroes of Heine–Stieltjes Polynomials

We determine the limiting density of the zeroes of Heine–Stieltjes polynomials (or of any set of points satisfying the conclusion of Heine–Stieltjes Theorem) in the thermodynamic limit and use this to prove a strong law of large numbers for the zeroes.     

Macroscopic Dimension of 3-Manifolds

In this paper we give the answer to the Gromov's question about the macroscopic dimension of universal coverings of closed manifolds in dimension 3. We prove that the macroscopic dimension of a universal covering of a closed Riemannian 3-manifold cannot be equal to 2.     

Identification of pyrrolo-pyridine derivatives as novel class of antibacterials

Molecular Diversity - A series of 5-oxo-4H-pyrrolo[3,2-b]pyridine derivatives was identified as novel class of highly potent antibacterial agents during an extensive large-scale high-throughput...     

Travelling wave mathematical analysis and efficient numerical resolution for a one-dimensional model of solid propellant combustion

We investigate a model of solid propellant combustion involving surface pyrolysis coupled to finite activation energy gas-phase combustion. Existence and uniqueness of a travelling wave solution are established by extending dynamical system tools classically used for premixed flames, dealing with the additional difficulty arising from the surface regression and pyrolysis. An efficient shooting method allows to solve the problem in phase space without resorting to space discretisation nor fixed-point Newton iterations. The results are compared to solutions from a CFD code developed at ONERA, assessing the efficiency and potential of the method, and the impact of the modelling assumptions is evaluated through parametric studies.     

Spectral stability of periodic waves in the generalized reduced Ostrovsky equation

We consider stability of periodic travelling waves in the generalized reduced Ostrovsky equation with respect to co-periodic perturbations. Compared to the recent literature, we give a simple argument that proves spectral stability of all smooth periodic travelling waves independent of the nonlinearity power. The argument is based on the energy convexity and does not use coordinate transformations of the reduced Ostrovsky equations to the semi-linear equations of the Klein–Gordon type.     

Some Remarks on SLE Bubbles and Schramm’s Two-point Observable

Simmons and Cardy recently predicted a formula for the probability that the chordal SLE_8/3 path passes to the left of two points in the upper half-plane. In this paper we give a rigorous proof of their formula. Starting from this result, we derive explicit expressions for several natural connectivity functions for SLE_8/3 bubbles conditioned to be of macroscopic size. By passing to a limit with such a bubble we construct a certain chordal restriction measure and in this way obtain a proof of a formula for the probability that two given points are between two commuting SLE_8/3 paths. The one-point version of this result has been predicted by Gamsa and Cardy. Finally, we derive an integral formula for the second moment of the area of an SLE_8/3 bubble conditioned to have radius 1. We evaluate the area integral numerically and relate its value to a hypothesis that the area follows the Airy distribution.