Synthesis and Crystal Structure of a Copper（Ⅱ） Compound Constructed by N-（4,6- Dimethoxylpyrimidin）-N＇-（ethoxycarbonyl）thiourea

A copper（Ⅱ） complex Cu（L）2（NO3）2 constructed by the L （L = N-（4,6-dimethoxylpyrimidin）-N＇-（ethoxycarbonyl）thiourea） ligand crystallizes in monoclinic, space group C2/c with a = 16.2416（16）, b = 9.1385（7）, c = 22.0008（18） A, β = 108.077（2）°, V = 3104.3（5） A^3, Dc = 1.627 g/cm^3, Z = 4, C20H28CuN10O14S2, Mr = 760.18,μ（MoKa） = 0.920 mm^-1, F（000） = 1564, R = 0.0471 and wR = 0.1284 for 2239 observed reflections （I 〉 2σ（I））. X-ray diffraction shows the existence of weak complementary intramolecular N-H...O （DA） hydrogen bonds which further strengthen the coordination from the two L ligands with the Cu（Ⅱ） ion, intermolecular C-H...O hydrogen bonds and weak π...π stacking interactions, leading to the formation of a multi-dimensional supramolecular network.     

Ligand-Regulated Regiodivergent Hydrosilylation of Isoprene under Iron Catalysis

A method for the regiodivergent and stereoselective hydrosilylation of the basic industrial feedstock isoprene with unactivated silanes has been developed using earth-abundant iron catalysts. The manipulation of regioselectivity relies on fine modification of the coordination geometry of the iron center. While a bidentate pyridine imine ligand promoted the formation of allylic silanes through 4,1-addition, selectivity for the 3,4-adduct homoallylic silanes was observed with a tridentate nitrogen ligand. Experimental studies and analysis were carried out to elucidate the reaction mechanism and the factors enabling manipulation of the regioselectivity. This study contributes to the art of regioselectivity control in alkene hydrofunctionalization.     

Ⅱ类超导体相变特征热力学探析

本文 以 Ⅱ类超导体 Ａｂｒｉｋｏｓｏｖ磁通结构理论为依据,采用典型的热力学方法,论证了 Ⅱ类超导体在 Ｈｃ１相变点由 Ｍｅｉｓｓｎｅｒ态到低场混合态的相变,以及在 Ｈｃ２相变点由高场混合态到正常态的相变性质．我们的论证结果表明：Ⅱ类超导体在Ｈｅ相交点与Ｈｅ相变点的相变均为二级相变,两相的比热差方程直接依赖相平衡曲线关系,且理论值与实验值比较的一致性约为９０％．１引言 Ｉ类超导体的热力学一级相变理论已被大家所熟知,相比之下,Ⅱ类超导体热力学相变理论还有待于进一步发展与完善．曾在六十年代, Ｍｏｒｉｎ等人…     

Optimization of mesh screen for enhancing jet impingement heat transfer

The variations of flow structure and heat transfer characteristics of impinging air jets with respect to mesh solidity are compared for two mesh screen locations at small nozzle-to-plate spacings. Results show that the uniform incoming flow structure produces higher heat transfer rates in the impingement region. The heat transfer enhancement largely depends on nozzle-to-plate spacing, mesh solidity, and jet Reynolds number. The mechanism of heat transfer enhancement is analyzed in light of the field synergy principle.     

Biodegradable in situ gel-forming controlled vancomycin delivery system based on a thermosensitive mPEG-PLCPPA hydrogel

In this study, a biodegradable in situ gel-forming controlled drug delivery system based on a thermosensitive methoxy polyethylene glycol-co-poly (lactic acid-co-aromatic anhydride) (mPEG-PLCPPA) hydrogel was studied. The hydrogels were formed by micelle aggregation with rising temperature. The hydrogels underwent a temperature-dependent sol–gel–sol transition, which was a flowing sol at ambient temperature and a non-flowing gel at the physiological body temperature. The residual weight and pH value changes after degradation and the viscosity properties of the hydrogel were investigated. The in vitro release behavior of vancomycin from the mPEG-PLCPPA hydrogels at different concentrations was also investigated. The results showed that the mPEG-PLCPPA amphiphilic copolymer could self-assemble to form micelles at low concentrations, and that the particle sizes gradually increased with increasing temperature. The hydrogel maintained a stable degradation rate and provided a moderate pH microenvironment after degradation for 30 days. Vancomycin sustained a stable release profile from the hydrogel over a 10-day period. Furthermore, good biocompatibility was proven by MTT assay and live and dead test. Therefore, the mPEG-PLCPPA hydrogel shows promise as an injectable local antibiotic delivery system.     

Construction of Bridged Benzazepines via Photo-Induced Dearomatization

Bridged benzazepine scaffolds, possessing unique structural and physicochemical activities, are widespread in various natural products and drugs. The construction of these skeletons often requires elaborate synthetic effort with low efficiency. Herein, we develop a simple and divergent approach for constructing various bridged benzazepines by a photocatalytic intermolecular dearomatization of naphthalene derivatives with readily available α-amino acids. The bridged motif is created via a cascade sequence involving photocatalytic 1,4-hydroaminoalkylation, alkene isomerization and cyclization. Interestingly, the diastereoselectivity can be regulated through different reaction modes in the cyclization step. Moreover, aminohydroxylation and its further bromination have also been demonstrated to access highly functionalized bridged benzazepines. Preliminary mechanistic studies have been performed to get insights into the mechanism. This method provides a divergent synthetic approach for construction of highly functionalized bridged benzazepines, which have been otherwise difficult to access.     

催化NH吲哚的C2异戊烯基化反应:肽后期多样化和两步全合成tryprostatin B

异戊烯基化吲哚生物碱是一类同时具有吲哚环和类异戊二烯基团的天然产物,主要来源于各种真菌中.异戊烯基的存在可以增强化合物的亲脂性,使其能够更容易地穿过脂溶性的细胞膜与靶蛋白相结合,因此,这类天然产物往往表现出优异的生物活性.例如,从烟曲霉中分离的吲哚生物碱tryprostatins A和B是由L-色氨酸和L-脯氨酸组合而...     

声空化场下单相对流传热的实验研究

以水、乙醇和丙酮为工质，首次通过实验研究了声空化场的热效应、单相对流换热受空化时间．纳米颗粒和实验工质的影响及恒热流密度下单相对流换热系数随声空化强度的变化，并就其强化传热机理进行了分析。     

All-optical switching and passive mode-locking based on non-linear polarization rotation in a semiconductor quantum well amplifier

Owing to differences in the selection rules of electron transitions between TE and TM modes in a quantum well structure, and optical amplifier with such a structure manifests linear birefringence and anisotropy of gain-absorption saturation. The anisotropy leads to the evolution of power-dependent polarization in the optical amplifier. We demonstrate experimentally efficient non-linear self-switching based on this phenomenon in an InGaAs/GaAs single quantum well amplifier. Also, by utilizing the non-linear polarization evolution, we show numerically passive mode-locking of a semiconductor laser with a ring cavity.