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61.
A parametric study to increase the enantioselectivity of Candida rugosa lipase (CRL) toward S-Naproxen production by the hydrolysis of racemic Naproxen methyl ester in an aqueous-organic biphasic
batch system was carried out. Effects of organic solvent type, aqueous phase/organic solvent volume ratio, agitation rate,
concentrations of the substrate and the enzyme, pH of the aqueous phase, and temperature on the en antiomeric excess for the
product (eep), on the enantiomeric ratio (E) and on the conversion (x) were evaluated. Employing isooctane as the solvent resulted in
higher eep, E, and x than those obtained in hexane, cyclohexane, and toluene. The higher the volume ratio of aqueous phase/organic solvent
employed, the higher the conversion and enantioselectivity achieved. The increase in agitation rate increased the hydrolysis
rate. Higher concentration of racemic Naproxen methyl ester than 10 mg/mL decreased both the conversion and enantioselectivity.
The increase in crude CRL concentration resulted in enhancement of x, but the decrease of feep and E. Acidic pH led to higher conversion and enantioselectivity than the medium and alkaline pH values. A further increase
in temperature to over 45°C decreased the conversion and enantioselectivity. The highest enantiomeric ratio achieved in the
S-Naproxen production was E=171.1, with x=49.8% and eep=95.7%. 相似文献
62.
Asymmetric organocatalytic sulfa-Michael reactions give access to enantiomerically enriched sulfur containing adducts that can be used as valuable chiral building blocks. A variety of chalcone derivatives were allowed to react with methyl thioglycolate under optimized conditions, in the presence of a bifunctional quinine derived sterically encumbered squaramide organocatalyst, giving rise to excellent stereoselectivities, up to 99%?ee. The designed catalyst system proved to be efficient even at gram scale and under milder reaction conditions. 相似文献
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Bozkir Cem Deniz Caglar Kundakcioglu O. Erhun Henry Andrea C. 《Journal of Global Optimization》2022,83(3):565-584
Journal of Global Optimization - In this study, we consider a health network that faces uncertain supply disruptions in the form of regional, nationwide, or worldwide drug shortages. Each hospital... 相似文献
68.
Cemil Ibis Nahide Gulsah Deniz 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):2324-2332
New S-,O-substituted naphthoquinone compounds (3a, 4b, 6, 7c, 9d, 10, 12, 13c, 14d, 15) were synthesized via vinilic substitution. 2,3-Dichloro-1,4-naphthoquinone gave 3a and 4b with 4,4′-thiobisbenzenethiol, respectively. Compounds 6 and 7c were obtained from the reaction of 2,3-dichloro-1,4-naphthoquinone with cyclohexylmercaptane. The compounds 9d and 10 were prepared from the reaction of 2,3-dichloro-1,4-naphthoquinone with 6-mercapto-1-hexanol. Compounds 12, 13c, 14d, and 15 were synthesized from the reaction of 2,3-dichloro-1,4-naphthoquinone with 1,6-hexanedithiol. Their structures were characterized by micro analysis, FT-IR, 1H NMR, 13C NMR, MS, UV-Vis, and fluorescence spectroscopy. 相似文献
69.
Two new lucidin type anthraquinone glycosides, putorinoside A (1) and putorinoside B (2) were isolated from Putoria calabrica, in addition to two known anthraquinone glycosides, lucidin 3-O-beta-glucopyranoside (3) and lucidin 3-O-primeveroside (4). Based on spectroscopic data, putorinosides A and B were identified as 2-hydroxymethyl-1-methoxy-3,5,6-trihydroxyanthraquinone 3-O-beta-glucopyranoside and 2-hydroxymethyl-1-methoxy-3,6-dihydroxyanthraquinone 3-O-beta-glucopyranoside, respectively. 相似文献
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