DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes

Background  

Our group previously demonstrated that a DNA plasmid encoding the mycobacterial 65-kDa heat shock protein (DNA-HSP65) displayed prophylactic and therapeutic effect in a mice model for tuberculosis. This protection was attributed to induction of a strong cellular immunity against HSP65. As specific immunity to HSP60 family has been detected in arthritis, multiple sclerosis and diabetes, the vaccination procedure with DNA-HSP65 could induce a cross-reactive immune response that could trigger or worsen these autoimmune diseases.     

Analogy between unconventional superconductivity and unconventional states of liquid crystals

An analogy is stressed between the order-parameter symmetries of the two-dimensional d-pairing wave superconductors and of liquid-crystal mesophases formed from achiral bent-shaped molecules. It leads to a definition of a class of liquid-crystal states which are the analogs of the unconventional superconducting states, and are characterized by a loss of discrete symmetry operations of the parent state.     

Creatine kinase B deficient neurons exhibit an increased fraction of motile mitochondria

Background  

Neurons require an elaborate system of intracellular transport to distribute cargo throughout axonal and dendritic projections. Active anterograde and retrograde transport of mitochondria serves in local energy distribution, but at the same time also requires input of ATP. Here we studied whether brain-type creatine kinase (CK-B), a key enzyme for high-energy phosphoryl transfer between ATP and CrP in brain, has an intermediary role in the reciprocal coordination between mitochondrial motility and energy distribution. Therefore, we analysed the impact of brain-type creatine kinase (CK-B) deficiency on transport activity and velocity of mitochondria in primary murine neurons and made a comparison to the fate of amyloid precursor protein (APP) cargo in these cells, using live cell imaging.     

Semiconductor-metal transition in doped (CH)x: Thermoelectric power

Thermoelectric power studies of polyacetylene have been carried out as a function of dopant concentration and temperature. The thermopower of pure trans-(CH)_x is large $\text{(S =}\text{+850 μ V}\text{°K}\text{)}$ and positive consistent with p-type material. With iodine doping, (CHI_y)_x, the thermopower remains positive over the full range of concentration 0 < y < 0.22. The semiconductor-metal transition is clearly observed at n_c ? 3 mole %; S falls dramatically from $\text{S =}\text{+850 μ V}\text{°K}$ at y = 0.003 to $\text{S =}\text{+30 μ V}\text{°K}$ at y = 0.03. At higher concentrations, S remains nearly constant saturating at $\text{+18 μ V}\text{°K}$ in the heavily doped metallic polymer. Temperature dependences are consistent with metallic behavior at the highest dopant concentrations and hopping transport in the undoped and lightly doped polymer.     

Search for isovector giant monopole resonances via the Pb(3He,tp) reaction

The (nat)Pb(3He,tp) reaction at E(3He) = 177 MeV was studied to identify 2Planck's over 2piomega isovector monopole strength in Bi isotopes. Monopole strength was found in the region -45相似文献