Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion

Background  

Multiple neuropeptides, sometimes with opposing functions, can be produced from one precursor gene. To study the roles of the different neuropeptides encoded by one large precursor we developed a method to overexpress minigenes and establish local secretion.     

Neutral transverse momentum spectra in 60 and 200A·GeV16O+nucleus and proton+nucleus reactions

Transverse momentum (p _T) distributions fo inclusive photons and neutral pions at midrapidity are measured with a lead glass calorimeter in 60 and are measured with a lead glass calorimeter in 60 and 200A·Gev¹⁶O+nucleus and and proton+nucleus reactions. Inclusive photon distributions are compared for central and peripheral reactions. The degree of centrality is determined either from the charged particle multiplicity or from the remaining projectile energy in the forward direction. Deviations from a nucleus+nucleus interaction model based upon linear extrapolation from p+p reactions are observed in central¹⁶O+Au data. The variation of theaverage transverse momentum is investigated as function of centrality. The target-mass and energy dependence of π⁰ p _T distributions are presented. For¹⁶O+Au a change of slope in these distributions is observed atp _t ≈0.8 GeV/c compatible with hydrodynamic expansion models.     

A study of the centrally produced π+π−π0 system formed in the reactionpp→p f (π+π−π0)p s at 300 GeV/c

The reactionpp→p _f (π⁺π^?π⁰)p _s , where the π⁺π^?π⁰ system is centrally produced, has been studied at 300 GeV/c. The π⁺π^?π⁰ mass spectrum shows evidence for the η, ω anda ₂ (1320) as well as an enhancement in thea ₁ (1260) region. A Dalitz plot analysis of the π⁺π^?π⁰ system has been performed. Thea ₁ (1260) parameters coming from the fit of the 1⁺ S wave arem=1208±15 MeV and Γ=430±50 MeV. No evidence is found for theh ₁(1170) orh ₁(1380).     

The production ofJ/ψ in 200 GeV/A oxygen-uranium interactions

The dimuon production in 200 GeV/nucleon oxygen-uranium interactions is studied by the NA 38 Collaboration. The production ofJ/ψ, correlated with the transverse energyET, is investigated and compared to the continuum, as a function of the dimuon massM and transverse momentumPT. A value of 0.64±0.06 is found for the ratio (ψ/Continuum at highET)/(ψ/Continuum at lowET), from which theJ/ψ relative suppression can be extracted. This suppression is enhanced at lowPT.     

Production ofρ +, −, 0 (770),η(550), ω(783) andf 2(1270) mesons in\bar v neon and ν neon charged current interactions

The production of the meson resonances ?(770) (all three charge states), η(550), ω(783) andf ₂(1270) in \(\bar v\) Ne and ν Ne charged current interactions is investigated in a bubble chamber experiment with BEBC at CERN. Except for thef ₂, the main features of resonance production are reasonably well described by the Lund model, although the average resonance multiplicities are overestimated by the model by (67±30)%. The average multiplicities of all resonances, including thef ₂, are well reproduced by a semiempirical model, whose parameters were determined from hadron interaction data.