Digital solution of temperature distribution in an electrical machine using network analogy

An analytical method which predicts the temperature rise of the rotor and stator packets, and the associated endwindings of an induction motor is presented. The method also enables the prediction of the temperature rise of the coolant at discrete points in its flow path through the motor.     

Machinability improvement in Inconel-718 by enhanced tribological and thermal environment using textured tool

Journal of Thermal Analysis and Calorimetry - Machinability of Inconel-718 superalloy in conventional approach is poor—this fact necessitates advanced technological adoption such as improved...     

Ferroelectric phases in non-symmetric achiral bent liquid crystals towards ambient temperatures: a novel series with oxadiazol as central moiety

Extensive survey carried out in bent liquid crystals (BLCs) exhibiting ferroelectric (FE) phases suggested for the design of non-symmetric (NS) frame. Novel series of BLCs (C₈C_m) with distinct lateral moieties and heterocyclic central (oxadiazole) moiety, viz., octyl 4-(5-(4´-(alkyloxy) biphenyl-4-yl)-1,2,4-oxadiazol-3-yl)benzoates, are reported. NS BLC frame is realised by incorporating differing number of aromatic cores and varied length of end chains in the lateral moieties. Lateral moiety with biphenyl core is prepared by Suzuki coupling. Purity of the BLC product is confirmed by ¹H NMR and elemental analysis. LC phases exhibited by C₈C_m series of BLCs for m = 8, 10, 12, 15 and 16 are characterised by polarisation optical microscopy (POM), differential scanning calorimetry (DSC) and spontaneous polarisation (P_S) techniques. C₈C_m series are found to exhibit SmA, CrystalB, B₂, B₅, SmG and SmE phase variance. SmG occurs as monotropic phase. Temperature variation of P_S(T) studied in FE B₂ and B₅ phases by field reversal method infers a moderate P_S value of ~80–100 nC · cm^?2. Order parameter growth in FE B₂ and B₅ phases is analysed through P_S(T). Normalised order parameter θ_N exhibits asymptotic behaviour with universal temperature T^U. Influence of aromatic cores and length of end chains (in lateral moieties) on the thermal stability of FE phases is discussed in the wake of the data on other BLCs.     

Application of a UPLC‐MS/MS method for the analysis of alosetron in human plasma to support a bioequivalence study in healthy males and females

A simple, rapid and sensitive ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method has been developed and validated for the determination of alosetron (ALO) in human plasma. The assay method involved solid‐phase extraction of ALO and ALO 13C‐d3 as internal standard (IS) on a LichroSep DVB‐HL (30 mg, 1 cm³) cartridge. The chromatography was performed on an Acquity UPLC BEH C₁₈ (50 × 2.1 mm, 1.7 µm) column using acetonitrile and 2.0 mm ammonium formate, pH 3.0 adjusted with 0.1% formic acid (80:20, v/v) as the mobile phase in an isocratic mode. For quantitative analysis, the multiple reaction monitoring transitions studied were m/z 295.1/201.0 for ALO and m/z 299.1/205.1 for IS in the positive ionization mode. The method was validated over a concentration range of 0.01–10.0 ng/mL for ALO. Post‐column infusion experiment showed no positive or negative peaks in the elution range of the analyte and IS after injection of extracted blank plasma. The extent of ion‐suppression/enhancement, expressed as IS‐normalized matrix factor, varied from 0.96 to 1.04. The assay recovery was within 97–103% for ALO and IS. The method was successfully applied to support a bioequivalence study of 1.0 mg alosetron tablets in 28 healthy Indian male and female subjects. Copyright © 2015 John Wiley & Sons, Ltd.     

Synthesis on templates : Regiospecific synthesis of imidazoles

A new, biomimetic template operated strategy has been developed leading to regiospecific synthesis of imidazoles (CHARTS I & II).     

Sulfonamides and carbamates of 3-fluoro-4-morpholinoaniline (linezolid intermediate): synthesis,antimicrobial activity and molecular docking study

Research on Chemical Intermediates - The precursor compound 3-fluoro-4-morpholinoaniline (7) is an important intermediate of the antibiotic drug linezolid and was synthesized initially by the...