排序方式: 共有42条查询结果,搜索用时 531 毫秒
31.
32.
33.
Zambelli B Bellucci M Danielli A Scarlato V Ciurli S 《Chemical communications (Cambridge, England)》2007,(35):3649-3651
The binding constants between Ni2+ and Helicobacterpylori NikR have been determined using isothermal titration microcalorimetry in order to rationalize the role of this protein as a nickel-dependent biological sensor. 相似文献
34.
Giulia Battistelli Maria Proetto Alexandra Mavridi-Printezi Matteo Calvaresi Alberto Danielli Paolo Emidio Constantini Claudia Battistella Nathan C. Gianneschi Marco Montalti 《Chemical science》2022,13(17):4884
Fluorogenic nanoparticles (NPs) able to sense different physiological environments and respond with disaggregation and fluorescence switching OFF/ON are powerful tools in nanomedicine as they can combine diagnostics with therapeutic action. pH-responsive NPs are particularly interesting as they can differentiate cancer tissues from healthy ones, they can drive selective intracellular drug release and they can act as pH biosensors. Controlled polymerization techniques are the basis of such materials as they provide solid routes towards the synthesis of pH-responsive block copolymers that are able to assemble/disassemble following protonation/deprotonation. Ring opening metathesis polymerization (ROMP), in particular, has been recently exploited for the development of experimental nanomedicines owing to the efficient direct polymerization of both natural and synthetic functionalities. Here, we capitalize on these features and provide synthetic routes for the design of pH-responsive fluorogenic micelles via the assembly of ROMP block-copolymers. While detailed photophysical characterization validates the pH response, a proof of concept experiment in a model cancer cell line confirmed the activity of the biocompatible micelles in relevant biological environments, therefore pointing out the potential of this approach in the development of novel nano-theranostic agents.pH-responsive micelles disassembly, upon acidification during lysosomal uptake, leads to fluorescence switch ON. These nanoparticles are promising candidates for the design of novel stimuli-responsive drug delivery systems. 相似文献
35.
36.
37.
38.
39.
40.