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41.
Control of the Electronic Ground State on an Electron‐Transfer Copper Site by Second‐Sphere Perturbations
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Marcos N. Morgada Dr. Luciano A. Abriata Ulises Zitare Dr. Damian Alvarez‐Paggi Prof. Daniel H. Murgida Prof. Alejandro J. Vila 《Angewandte Chemie (International ed. in English)》2014,53(24):6188-6192
The CuA center is a dinuclear copper site that serves as an optimized hub for long‐range electron transfer in heme–copper terminal oxidases. Its electronic structure can be described in terms of a σu* ground‐state wavefunction with an alternative, less populated ground state of πu symmetry, which is thermally accessible. It is now shown that second‐sphere mutations in the CuA containing subunit of Thermus thermophilus ba3 oxidase perturb the electronic structure, which leads to a substantial increase in the population of the πu state, as shown by different spectroscopic methods. This perturbation does not affect the redox potential of the metal site, and despite an increase in the reorganization energy, it is not detrimental to the electron‐transfer kinetics. The mutations were achieved by replacing the loops that are involved in protein–protein interactions with cytochrome c, suggesting that transient protein binding could also elicit ground‐state switching in the oxidase, which enables alternative electron‐transfer pathways. 相似文献
42.
Directing the self-assembly of organic building blocks with 2D templates has been a promising method to create molecular superstructures having unique physicochemical properties. In this work the on-surface self-assembly of simple ditopic functional molecules confined inside periodic nanotemplates was modeled by means of the lattice Monte Carlo simulation method. Two types of confinement, that is honeycomb porous networks and parallel grooves of controlled diameter and width were used in the calculations. Additionally, the effect of (pro)chirality of the adsorbing molecules on the outcome of the templated self-assembly was examined. To that end, enantiopure and racemic assemblies were studied and the resulting structures were identified and classified. The obtained findings demonstrated that suitable tuning of the structural parameters of the templates enables directing the self-assembly towards linear and cyclic aggregates with controlled size. Moreover, chiral resolution of the molecular conformers using honeycomb networks with adjusted pore size was found possible. Our theoretical predictions can be helpful in designing structured surfaces to direct self-assembly and polymerization of organic functional building blocks. 相似文献
43.
Dr. Ines E. Collings Dr. Elena Bykova Dr. Maxim Bykov Dr. Sylvain Petitgirard Dr. Michael Hanfland Dr. Damian Paliwoda Prof. Leonid Dubrovinsky Prof. Natalia Dubrovinskaia 《Chemphyschem》2016,17(21):3369-3372
The incorporation of noble gas atoms, in particular neon, into the pores of network structures is very challenging due to the weak interactions they experience with the network solid. Using high‐pressure single‐crystal X‐ray diffraction, we demonstrate that neon atoms enter into the extended network of ammonium metal formates, thus forming compounds Nex[NH4][M(HCOO)3]. This phenomenon modifies the compressional and structural behaviours of the ammonium metal formates under pressure. The neon atoms can be clearly localised within the centre of [M(HCOO)3]5 cages and the total saturation of this site is achieved after ~1.5 GPa. We find that by using argon as the pressure‐transmitting medium, the inclusion inside [NH4][M(HCOO)3] is inhibited due to the larger size of the argon. This study illustrates the size selectivity of [NH4][M(HCOO)3] compounds between neon and argon insertion under pressure, and the effect of inclusion on the high‐pressure behaviour of neon‐bearing ammonium metal formates. 相似文献
44.
Stahl F Moran D von Ragué Schleyer P Prall M Schreiner PR 《The Journal of organic chemistry》2002,67(5):1453-1461
Aromaticity criteria (magnetic susceptibility exaltations, nucleus independent chemical shifts (NICS), and aromatic stabilization energy (ASE) evaluations) for enediyne and enyne-allene cyclizations evaluated at (UBS)-BLYP/6-31G* all agree that the degrees of cyclic electron delocalization of the benzenoid systems formed by the Bergman (3) and Myers-Saito reactions (5) are comparable to benzene. The reaction enthalpy differences between the parent cyclizations and their benzannelated analogues are not entirely due to disparities in gained ASE during the reactions. The alternative formation of fulvene biradicals is not accompanied by favorable aromatic effects. 相似文献
45.
Computational studies have been used to examine the structural and energetic effects of adding small numbers of water molecules to ammonia, methylamine, dimethylamine, and trimethylamine, and their respective ammoniums ions using the effective fragment potential method. Distinct structural effects with only a few fragment water molecules are revealed. The complexity of structures increases with the number of water fragments with the water fragments forming complex networks. Structural and energetic effects are used to probe the so-called anomalous basicity effect of ammonia and the methylamines on going from the gas phase to aqueous solution. 相似文献
46.
[formula: see text] Apoptolidin (1) is a novel oncolytic lead that induces apoptosis in transformed cell lines with exceptional selectivity. We report the isolation and characterization of a ring-expanded macrolide isomer of apoptolidin: isoapoptolidin (2). The solution conformation of isoapoptolidin is described. The rate of isomerization was measured under biologically relevant conditions and found to approach equilibrium within the time frame of most cell-based assays. Isoapoptolidin's ability to inhibit mitochondrial F0F1-ATPase is over 10-fold less than that of apoptolidin. 相似文献
47.
Tadeusz Jankowski 《Czechoslovak Mathematical Journal》2002,52(3):553-563
The method of quasilinearization is a well-known technique for obtaining approximate solutions of nonlinear differential equations. In this paper we apply this technique to functional differential problems. It is shown that linear iterations converge to the unique solution and this convergence is superlinear. 相似文献
48.
We present a two-photon fluorescence microscope based on a three-port single-mode optical fiber coupler. It is found that the coupler behaves as a low-pass filter that can deliver an ultrashort-pulsed laser beam of as much as 150 mW of power in the wavelength range from 770 to 870 nm as well as collect a two-photon fluorescence signal in the visible range. As a result of using the fiber coupler, the new two-photon imaging system exhibts a number of advantages, including a compact arrangement, freedom from vibration from lasers and electronic devices, self-alignment, reduction of multiple scattering, and an enhanced optical sectioning effect. The effectiveness of the new instrument is demonstrated with a set of three-dimensional images of biological samples. This instrument may make two-photon fluorescence endoscopy possible for in vivo medical applications. 相似文献
49.
A theorem of Green, Lazarsfeld and Simpson (formerly a conjecture of Beauville and Catanese) states that certain naturally defined subvarieties of the Picard variety of a smooth projective complex variety are unions of translates of abelian subvarieties by torsion points. Their proof uses analytic methods. We refine and give a completely new proof of their result. Our proof combines galois-theoretic methods and algebraic geometry in positive characteristic. When the variety has a model over a function field and its Picard variety has no isotrivial factors, we show how to replace the galois-theoretic results we need by results from model theory (mathematical logic). Furthermore, we prove partial analogs of the conjecture of Beauville and Catanese in positive characteristic. 相似文献
50.
The inelastic neutron scattering (INS) and periodic density functional theory (DFT) vibrational spectra of H3B:NH3 are reported to 1600 cm-1. The H3B:NH3 structural and INS features, specifically the reduced solid-state B:N dative bond length and the altered B:N stretching frequency, are reproduced by the periodic DFT calculations, placing the B:N stretching mode at 800 cm-1, in excellent agreement with experiment relative to previous nonperiodic theoretical treatments of this molecule. 相似文献