The microwave spectrum of 2, 5-dihydropyrrole

The microwave spectrum of 2, 5-dihydropyrrole has been measured up to J = 25 in both the ground and first vibrational excited states. The rotational constants for ν = 0 are A = 7650.61 ± 0.04 MHz, B = 7597.38 ± 0.04 MHz, C = 4085.63 ± 0.04 MHz and for ν = 1 the constants are A = 7650.65 ± 0.04 MHz, B = 7597.12 ± 0.04 MHz and C = 4085.71 ± 0.04 MHz. Centrifugal distortion corrections are included.     

Microanalysis of amoxicillin, flucloxacillin, and rifampicin in neonatal plasma

Simple and rapid reversed-phase high-performance liquid chromatographic assays with ultraviolet detection have been developed and validated for the determination of amoxicillin, flucloxacillin and rifampicin in neonatal plasma. Plasma samples were either precipitated with perchloric acid (amoxicillin) or methanol (rifampicin) or extracted with methylene chloride (flucloxacillin). Precision coefficients of variation and inaccuracy were less than 15% for all three assays. Only small sample volumes (20-40 microL) were required, making the assays suitable for therapeutic drug monitoring and pharmacokinetic studies in preterm and term neonates. The assays have successfully been applied to analysis of amoxicillin, flucloxacillin and rifampicin in previously published pharmacokinetic studies in neonates.