Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells

The innovative strategy of using nanoparticles in radiotherapy has become an exciting topic due to the possibility of simultaneously improving local efficiency of radiation in tumors and real-time monitoring of the delivered doses. Yttrium oxide (Y₂O₃) nanoparticles (NPs) are used in material science to prepare phosphors for various applications including X-ray induced photodynamic therapy and in situ nano-dosimetry, but few available reports only addressed the effect induced in cells by combined exposure to different doses of superficial X-ray radiation and nanoparticles. Herein, we analyzed changes induced in melanoma cells by exposure to different doses of X-ray radiation and various concentrations of Y₂O₃ NPs. By evaluation of cell mitochondrial activity and production of intracellular reactive oxygen species (ROS), we estimated that 2, 4, and 6 Gy X-ray radiation doses are visibly altering the cells by inducing ROS production with increasing the dose while at 6 Gy the mitochondrial activity is also affected. Separately, high-concentrated solutions of 25, 50, and 100 µg/mL Y₂O₃ NPs were also found to affect the cells by inducing ROS production with the increase of concentration. Additionally, the colony-forming units assay evidenced a rather synergic effect of NPs and radiation. By adding the NPs to cells before irradiation, a decrease of the number of proliferating cell colonies was observed with increase of X-ray dose. DNA damage was evidenced by quantifying the γ-H2AX foci for cells treated with Y₂O₃ NPs and exposed to superficial X-ray radiation. Proteomic profile confirmed that a combined effect of 50 µg/mL Y₂O₃ NPs and 6 Gy X-ray dose induced mitochondria alterations and DNA changes in melanoma cells.     

Hopf Algebras of Dimension 16

We complete the classification of Hopf algebras of dimension 16 over an algebraically closed field of characteristic zero. We show that a non-semisimple Hopf algebra of dimension 16, has either the Chevalley property or its dual is pointed.     

The first example of a recursive function which is not primitive recursive

The first example of a recursive function which is not primitive recursive is usually attributed to W. Ackermann. The authors of the present paper show that such an example can also be found in a paper by G. Sudan, published concomitantly with Ackermann's paper.     

On Harmonic and C-Harmonic 1-Differentiable Forms on Sasakian Manifolds

In this paper, we firstly extend some classical operators on Sasakian manifolds acting to 1-differentiable forms on Sasakian manifolds. Next in a similar manner with the study of C-harmonic forms, we define and extend such a study for the case of 1-differentiable forms on Sasakian manifolds.     

Approaching minimum time control of timed continuous Petri nets

This paper considers the problem of controlling timed continuous Petri nets under infinite server semantics. The proposed control strategy assigns piecewise constant flows to transitions in order to reach the target state. First, by using linear programming, a method driving the system from the initial to the target state through a linear trajectory is developed. Then, in order to improve the time of the trajectory, intermediate states are added by means of bilinear programming. Finally, in order to handle potential perturbations, we develop a closed loop control strategy that follows the trajectory computed by the open loop control by calculating a new state after each time step. The algorithms developed here are applied to a manufacturing system.     

Flasque resolutions of reductive group schemes

We generalize Colliot-Thélène’s construction of flasque resolutions of reductive group schemes over a field to a broad class of base schemes.     

Functional Liquid Crystal Elastomers Based on Dynamic Covalent Chemistry

The marriage of liquid crystal elastomers with dynamic covalent chemistry can be a new paradigm for the development of dynamic and intelligent polymers with versatile functionalities, which is of paramount significance for many emerging applications such as adaptive optics, soft robotics, bioinspired camouflage, 3D/4D printing technology and beyond. Read more in the Review by Wang, Feng et al. ( 10.1002/chem.202201957 )     

Visible-Light Assisted Covalent Surface Functionalization of Reduced Graphene Oxide Nanosheets with Arylazo Sulfones

We present an environmentally benign methodology for the covalent functionalization (arylation) of reduced graphene oxide (rGO) nanosheets with arylazo sulfones. A variety of tagged aryl units were conveniently accommodated at the rGO surface via visible-light irradiation of suspensions of carbon nanostructured materials in aqueous media. Mild reaction conditions, absence of photosensitizers, functional group tolerance and high atomic fractions (XPS analysis) represent some of the salient features characterizing the present methodology. Control experiments for the mechanistic elucidation (Raman analysis) and chemical nanomanipulation of the tagged rGO surfaces are also reported.