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排序方式: 共有103条查询结果,搜索用时 15 毫秒
91.
Dr. Yoan Brissonnet Coralie Assailly Dr. Amélie Saumonneau Dr. Julie Bouckaert Dr. Mike Maillasson Clémence Petitot Benoit Roubinet Dr. Blanka Didak Dr. Ludovic Landemarre Dr. Clarisse Bridot Dr. Ralf Blossey Prof. Dr. David Deniaud Dr. Xibo Yan Dr. Julien Bernard Prof. Dr. Charles Tellier Dr. Cyrille Grandjean Dr. Franck Daligault Dr. Sébastien G. Gouin 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(9):2358-2365
Sialidases (SAs) hydrolyze sialyl residues from glycoconjugates of the eukaryotic cell surface and are virulence factors expressed by pathogenic bacteria, viruses, and parasites. The catalytic domains of SAs are often flanked with carbohydrate-binding module(s) previously shown to bind sialosides and to enhance enzymatic catalytic efficiency. Herein, non-hydrolyzable multivalent thiosialosides were designed as probes and inhibitors of V. cholerae, T. cruzi, and S. pneumoniae (NanA) sialidases. NanA was truncated from the catalytic and lectinic domains (NanA-L and NanA-C) to probe their respective roles upon interacting with sialylated surfaces and the synthetically designed di- and polymeric thiosialosides. The NanA-L domain was shown to fully drive NanA binding, improving affinity for the thiosialylated surface and compounds by more than two orders of magnitude. Importantly, each thiosialoside grafted onto the polymer was also shown to reduce NanA and NanA-C catalytic activity with efficiency that was 3000-fold higher than that of the monovalent thiosialoside reference. These results extend the concept of multivalency for designing potent bacterial and parasitic sialidase inhibitors. 相似文献
92.
Clarisse Cornebise Flavie Courtaut Marie Taillandier-Coindard Josep Valls-Fonayet Tristan Richard David Monchaud Virginie Aires Dominique Delmas 《Molecules (Basel, Switzerland)》2020,25(23)
Age-related macular degeneration (AMD) is a degenerative disease of the retina where the molecular mechanism involves the production of vascular endothelial growth factor (VEGF), a factor of poor prognosis of the progression of the disease. Previous studies have shown that resveratrol, a polyphenol of grapevines, can prevent VEGF secretion induced by stress from retinal cells. Considering the fundamental role played by VEGF in development and progression of AMD, we investigate the potential effect of red wine extract (RWE) on VEGF secretion and its signaling pathway in human retinal cells ARPE-19. To examine the effect of RWE in ARPE-19, a quantitative and qualitative analysis of the RWE was performed by HPLC MS/MS. We show for the first time that RWE decreased VEGF-A secretion from ARPE-19 cells and its protein expression in concentration-dependent manner. RWE-induced alteration in VEGF-A production is associated with a down of VEGF-receptor 2 (VEGF-R2) protein expression and its phosphorylated intracytoplasmic domain. Subsequently, the activation of kinase pathway is disturbing and RWE prevents the phosphorylation of MEK and ERK 1/2 in human retinal cells ARPE-19. Finally, this study sheds light on the interest that the use of polyphenolic cocktails could represent in a prevention strategy. 相似文献
93.
94.
Fluorenyl Zinc Phosphonate Zn(H2O)PO3–C13H9·H2O: Hybrid Columnar Structure with Strong C–H···π Interactions
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Clarisse Bloyet Jean‐Michel Rueff Vincent Caignaert Jean‐François Lohier Julien Cardin Paul‐Alain Jaffrès Bernard Raveau 《无机化学与普通化学杂志》2017,643(3):250-255
A new zinc phosphonate Zn(H2O)PO3–C13H9 · H2O with a columnar structure was synthesized in hydrothermal conditions. This compound crystallizes in space group P21/c [a = 15.832(4) Å, b = 5.1915(10) Å, c = 17.519(4) Å and β = 114.479(6)°]. Its inorganic framework consists of isolated chains of corner‐sharing ZnO3(H2O) and PO3C tetrahedra. These chains are linked to fluorene cycles, forming hybrid columns, interconnected through C–H ··· π bonds. The photoluminescence properties of this hybrid material show that its emission bands are red shifted with respect to those of the mother phosphonic acid. This effect is explained on the basis of the structural constraints imposed by the inorganic Zn‐phosphonate chains. 相似文献
95.
Gerard Froyer Gu Y. Louarn Jean Louis Ciprelli Christian Clarisse 《Macromolecular Symposia》1997,122(1):355-362
Poly(3-octylthiophene) was used as a negative resist in e-beam microlithography. This conducting polymer fulfills the main requirements placed on materials which can be useful in this type of process. However, chemical modifications leading to crosslinking are not clearly established at this time. Approach of a mechanism is proposed in this paper which is supported by spectroscopic results obtained from the irradiated materials: it seems reasonable that crosslinking might occur between lateral alkyl groups eventually on carbon atoms in allylic position with the formation of a carbon - carbon double bond between locally stacked Poly(3-octylthiophene) chains. 相似文献
96.
FTIR Spectroscopy,SAXS and Electrical Conductivity Studies of the Hydrolysis and Condensation of Zirconium and Titanium Alkoxides 总被引:1,自引:0,他引:1
Harris Michael T. Singhal Amit Look Jee L. Smith-Kristensen Jennifer R. Lin Jar S. Toth Louis M. 《Journal of Sol-Gel Science and Technology》1997,8(1-3):41-47
A continuous flowing-rapid mixing technique was combined with FTIR, SAXS and electrical conductivity to study the early stages
of polymer formation and growth during the acid-catalyzed hydrolysis and condensation of titanium and zirconium alkoxides.
Reaction times as short as 80 milliseconds were investigated. FTIR spectroscopy was used to monitor the water and M−OR concentrations
during the reaction. Hydrolysis of ∼25–50% of the alkoxy groups was facile. The FTIR and SAXS data showed that condensation
was also very rapid. The activity and mobility of the ions in the solution were monitored by electrical conductivity measurements.
The decrease in the normalized solution conductivity during the reaction correlated with the loss of [M−OR]. Furthermore,
the radius of gyration of the growing polymers increased rapidly in regimes where the conductivity and [M−OR] decreased fastest.
This finding suggests that the mobility of some of the charge carrying species decreases because of the growth in size of
the polymers.
Managed by Lockheed-Martin Energy Systems, Inc. 相似文献
97.
98.
D.C. Look 《Surface science》2007,601(23):5315-5319
At low temperatures, typically up to 30 K or even higher, the electrical properties of bulk ZnO samples are nearly always dominated by a conductive near-surface region. Here we show that a single, low-temperature Hall-effect measurement, say at 20 K, and a reasonable assumption regarding the upper limit of the surface compensation ratio, yields a value of surface donor concentration ND,surf accurate to within about a factor two. Examples are given for bulk materials grown by the vapor-phase, melt, and hydrothermal processes. 相似文献
99.
Huguenard C Taulelle F Knott B Gan Z 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2002,156(1):131-137
The 2D satellite transition magic angle spinning (STMAS) experiment generates efficiently high-resolution isotropic NMR spectra of half-integer quadrupolar nuclei. The experiment involves excitation and coherence transfer of satellite transitions into the central transition. It requires efficient refocusing of satellite transitions and sample spinning at a very accurate magic angle to cancel the first-order quadrupolar interaction effect. A review of all parameters relevant to optimizing the STMAS experiment is presented, including pulse sequence calibration, regulating spinning speed, magic angle adjustment, optimization of satellite transition excitation, and coherence transfer for both I = 3/2 and I > or =5/2 nuclei. 相似文献
100.