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991.
Peter Pöchlauer Christian Himmer Paul Peringer Ernst Peter Müller Thomas Jenny Walter Petter 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-2):455-458
Abstract Spirophosphoranes are produced by reaction of 2–phenyl–1,3,2–dioxaphospholane with both 2- and 3–hydroxycarboxylic acid azides, whereas 1–phenyl–phospholane yields spirophosphoranes only upon reaction with the former. The structures of two spirophosphoranes have been determined by X-ray analysis. 相似文献
992.
Dr. Jakov Ivkovic Dr. Shalinee Jha Dipl.-Ing. Christian Lembacher-Fadum Dipl.-Ing. Johannes Puschnig Dr. Prashant Kumar Dr. Viktoria Reithofer Prof. Dr. Karl Gruber Prof. Dr. Peter Macheroux Prof. Dr. Rolf Breinbauer 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(56):14108-14120
Dipeptidyl peptidase III (DPP3) is a ubiquitously expressed Zn-dependent protease, which plays an important role in regulating endogenous peptide hormones, such as enkephalins or angiotensins. In previous biophysical studies, it could be shown that substrate binding is driven by a large entropic contribution due to the release of water molecules from the closing binding cleft. Here, the design, synthesis and biophysical characterization of peptidomimetic inhibitors is reported, using for the first time an hydroxyethylene transition-state mimetic for a metalloprotease. Efficient routes for the synthesis of both stereoisomers of the pseudopeptide core were developed, which allowed the synthesis of peptidomimetic inhibitors mimicking the VVYPW-motif of tynorphin. The best inhibitors inhibit DPP3 in the low μM range. Biophysical characterization by means of ITC measurement and X-ray crystallography confirm the unusual entropy-driven mode of binding. Stability assays demonstrated the desired stability of these inhibitors, which efficiently inhibited DPP3 in mouse brain homogenate. 相似文献
993.
Baptiste Schindler Agathe Depraz Depland Gina Renois-Predelus Gabriel Karras Bruno Concina Gulabi Celep Jacques Maurelli Vincent Loriot Eric Constant Richard Bredy Christian Bordas Franck Lépine Isabelle Compagnon 《International Journal for Ion Mobility Spectrometry》2017,20(3-4):119-124
An original workflow allowing inline FAIMS separation, electrospray ionization, mass analysis and ion spectroscopy (IRMPD: InfraRed Multiple Photon Dissociation) is presented for multidimensional molecular analysis. This new instrument consists of an ultraFAIMS (Owlstone) device interfaced to a linear ion trap (LTQ XL Thermo Scientific) which was modified for IRMPD spectroscopy. Two modes of operation are demonstrated on an isomeric mixture of paracetamol and 2-phenylglycine. In the first mode a FAIMS (high-Field Asymmetric waveform Ion Mobility Spectrometry) separation of the isomers is performed with a static compensation field for mass- and isomer- selective ion spectroscopy. In the second mode, the compensation field is scanned while the ions are irradiated at a fixed wavenumber. The advantages of this workflow as compared to traditional FAIMS-MS and IRMPD spectroscopy are described. The potential of the two modes for molecular spectroscopy and analytical applications, in particular the new “omics” are discussed. 相似文献
994.
995.
Leendert Vergeynst Herman Van Langenhove Pieter Joos Kristof Demeestere 《Analytica chimica acta》2013
Uniform guidelines for the data processing and validation of qualitative and quantitative multi-residue analysis using full-spectrum high-resolution mass spectrometry are scarce. 相似文献
996.
997.
We consider multi-component electrolyte solutions and plasmas in thermal equilibrium and define thermodynamic quantities for number densities which do not necessarily satisfy the condition of charge neutrality. It is shown that these quantities play a role in compressibility theorems for the pair correlation functions and in the generalized Debye shielding length. A fourth moment condition for the pair correlation functions is derived. We discuss to what extent non-uniform systems may be described in terms of local thermodynamics with added coulomb interactions. 相似文献
998.
999.
Sander Van Smaalen 《Phase Transitions》2013,86(1-4):169-174
The application of superspace groups to short-period superstructures is considered. For niobium tri-sulfide this is worked out in detail. It is shown that in that case the superspace group provides more symmetry then given by the space group of the supercell. Its consequences for the structure, the diffraction pattern and tensor-properties are discussed. 相似文献
1000.
J. van Soolingen R. J. De Lang R. den Besten P. A. A. Klusener N. Veldman A. L. Spek 《合成通讯》2013,43(11):1741-1744
1,8-Bis(diphenylphosphino)naphthalene has been obtained in good yields from 1,8-dilithionaphthalene and chlorodiphenylphosphine. 相似文献