全文获取类型
收费全文 | 187篇 |
免费 | 11篇 |
国内免费 | 4篇 |
专业分类
化学 | 169篇 |
晶体学 | 1篇 |
力学 | 2篇 |
数学 | 19篇 |
物理学 | 11篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2020年 | 2篇 |
2018年 | 1篇 |
2017年 | 2篇 |
2016年 | 4篇 |
2015年 | 2篇 |
2014年 | 4篇 |
2013年 | 10篇 |
2012年 | 8篇 |
2011年 | 16篇 |
2010年 | 8篇 |
2009年 | 4篇 |
2008年 | 16篇 |
2007年 | 6篇 |
2006年 | 18篇 |
2005年 | 15篇 |
2004年 | 16篇 |
2003年 | 10篇 |
2002年 | 9篇 |
2001年 | 6篇 |
2000年 | 3篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1994年 | 4篇 |
1993年 | 1篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1884年 | 1篇 |
排序方式: 共有202条查询结果,搜索用时 31 毫秒
61.
Dr. Carmen Sousa Dr. Coen de Graaf Andrii Rudavskyi Dr. Ria Broer Dr. Jörg Tatchen Dr. Mihajlo Etinski Dr. Christel M. Marian 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(51):17541-17551
The mechanism of the light‐induced spin crossover of the [Fe(bpy)3]2+ complex (bpy=2,2′‐bipyridine) has been studied by combining accurate electronic‐structure calculations and time‐dependent approaches to calculate intersystem‐crossing rates. We investigate how the initially excited metal‐to‐ligand charge transfer (MLCT) singlet state deactivates to the final metastable high‐spin state. Although ultrafast X‐ray free‐electron spectroscopy has established that the total timescale of this process is on the order of a few tenths of a picosecond, the details of the mechanisms still remain unclear. We determine all the intermediate electronic states along the pathway from low spin to high spin and give estimates for the deactivation times of the different stages. The calculations result in a total deactivation time on the same order of magnitude as the experimentally determined rate and indicate that the complex can reach the final high‐spin state by means of different deactivation channels. The optically populated excited singlet state rapidly decays to a triplet state with an Fe d6(${{\rm t}{{5\hfill \atop {\rm 2g}\hfill}}}$ ${{\rm e}{{1\hfill \atop {\rm g}\hfill}}}$ ) configuration either directly or by means of a triplet MLCT state. This triplet ligand‐field state could in principle decay directly to the final quintet state, but a much faster channel is provided by internal conversion to a lower‐lying triplet state and subsequent intersystem crossing to the high‐spin state. The deactivation rate to the low‐spin ground state is much smaller, which is in line with the large quantum yield reported for the process. 相似文献
62.
Structure of a Complex Formed by a Protein and a Helical Aromatic Oligoamide Foldamer at 2.1 Å Resolution
下载免费PDF全文
![点击此处可从《Angewandte Chemie (International ed. in English)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jérémie Buratto Dr. Cinzia Colombo Dr. Marine Stupfel Dr. Simon J. Dawson Dr. Christel Dolain Dr. Béatrice Langlois d'Estaintot Dr. Lucile Fischer Dr. Thierry Granier Dr. Michel Laguerre Dr. Bernard Gallois Dr. Ivan Huc 《Angewandte Chemie (International ed. in English)》2014,53(3):883-887
In the search of molecules that could recognize sizeable areas of protein surfaces, a series of ten helical aromatic oligoamide foldamers was synthesized on solid phase. The foldamers comprise three to five monomers carrying various proteinogenic side chains, and exist as racemic mixtures of interconverting right‐handed and left‐handed helices. Functionalization of the foldamers by a nanomolar ligand of human carbonic anhydrase II (HCA) ensured that they would be held in close proximity to the protein surface. Foldamer–protein interactions were screened by circular dichroism (CD). One foldamer displayed intense CD bands indicating that a preferred helix handedness is induced upon interacting with the protein surface. The crystal structure of the complex between this foldamer and HCA could be resolved at 2.1 Å resolution and revealed a number of unanticipated protein–foldamer, foldamer–foldamer, and protein–protein interactions. 相似文献
63.
64.
Vertical and adiabatic electronic spectra have been investigated by means of combined density functional and multi-reference configuration interaction methods. Spin–orbit coupling has been determined employing a non-empirical spin–orbit mean-field operator. In the vertical absorption spectrum of isolated 7H-adenine, the transitions to the lowest 1 state, the optically bright 1 state, and a so far unknown 1(πH → (Ryd, σ*)) state are predicted to lie very close to each other. The strong 1 transition at 4.8 eV is the lowest excitation of 1(π → π*) type in 7H-adenine. It is red shifted by about 0.3 eV with respect to the corresponding excitation in the 9H-tautomer. We find the global minimum on the S1 potential energy hypersurface at about 4.2 eV for a 1 electronic structure. A potential well with a minimum at 4.3 eV exhibits mixed 1 character. A planar 1 structure with a potential energy of 4.6 eV constitutes a stationary point on the S1 surface. At the present stage it is unclear whether it corresponds to a minimum or a saddle-point. The lowest-lying 1(π → (Ryd, σ*)) state is metastable with respect to N7–H14 bond dissociation. Its inner (Rydberg) potential well with an adiabatic excitation energy of 4.6 eV represents another minimum on the S1 PEH. From the theoretical results presented in this work, we conclude that isolated 7H-adenine will be able to emit photons for excitation energies below 4.7 eV(264 nm). Above this threshold singlet excited 7H-adenine can undergo ultrafast non-radiative relaxation to the electronic ground state, either by hydrogen detachment via the 1(π → (Ryd, σ*)) channel or via a conical intersection of the 1 state along a ring puckering mode. The 3 T1 state can be efficiently populated via intersystem crossing from one of the S1 potential energy wells. Large-amplitude motions in the T1 state along an out-of-plane distortional coordinate lead to significant configuration interaction of the 1 and 1 structures which lend intensity to the phosphorescence. 相似文献
65.
Srinivas K Kauffmann B Dolain C Léger JM Ghosez L Huc I 《Journal of the American Chemical Society》2008,130(40):13210-13211
The bromination of helically folded oligoamides of 8-amino-4-isobutoxy-2-quinolinecarboxylic acid by N-bromosuccinimide has been investigated. Bromination occurs preferentially if not exclusively at one position in the sequence despite the presence of multiple, up to seven, a priori comparable, reaction sites. Reactions are up to 2 orders of magnitude faster in a folded octamer than in a short nonhelical dimer, despite the steric hindrance that is expected in a compact folded conformation. The presence of substituents remote from the reaction site have considerable influence, resulting in the loss of regioselectivity, or in the slowing down of the reaction by several orders of magnitude. 相似文献
66.
Hempen C Wanschers H van der Sluijs Veer G 《Analytical and bioanalytical chemistry》2008,391(1):263-270
A liquid chromatography(LC)/electrospray ionization tandem mass spectrometry (MS) method for the quantitative determination
of total homocysteine and methylmalonic acid and the monitoring of methionine, homocystine and succinic acid in plasma has
been developed. The analytes are determined under the presence of the deuterated internal standards methylmalonic acid-d
3 and homocystine-d
8. Although methylmalonic acid can be determined directly, a reduction step has to be carried out to ensure the measurement
of total homocysteine. Ultrafiltration was applied afterwards to deproteinize the samples prior to LC/MS injection. LC/MS
analysis is carried out isocratically using a mobile phase consisting of 5% methanol and 95% of a 0.06 M formic acid solution
on a reversed-phase C18 column at a flow rate of 0.5 mL/min. The MS measurement was separated into several periods: homocysteine,
homocystine and methionine were determined in the positive-ion mode, whereas the determinations of methylmalonic acid and
succinic acid were carried out in the negative-ion mode. The intraday coefficients of variation (CVs) were 2.9% or less and
3.2% or less for homocysteine and methylmalonic acid, respectively. Interday CVs ranged from 3.8 to 5.9% for homocysteine
and from 3.5 to 6.3% for methylmalonic acid. Analyte concentrations could reliably be determined, also far below the reference
values. Furthermore, the linearity was determined and a correlation study with respect to the existing homocysteine and methylmalonic
acid methods at Medisch Spectrum Twente Hospital was carried out. 相似文献
67.
Extensive time-dependent DFT (TDDFT) and DFT/multireference configuration interaction (MRCI) calculations are performed on the singlet and triplet excited states of free-base porphyrin, with emphasis on intersystem crossing processes. The equilibrium geometries, as well as the vertical and adiabatic excitation energies of the lowest singlet and triplet excited states are determined. Single and double proton-transfer reactions in the first excited singlet state are explored. Harmonic vibrational frequencies are calculated at the equilibrium geometries of the ground state and of the lowest singlet and triplet excited states. Furthermore, spin–orbit coupling matrix elements of the lowest singlet and triplet states and their numerical derivatives with respect to nuclear displacements are computed. It is shown that opening of an unprotonated pyrrole ring as well as excited-state single and double proton transfer inside the porphyrin cavity lead to crossings of the potential energy curves of the lowest singlet and triplet excited states. It is also found that displacements along out-of-plane normal modes of the first excited singlet state cause a significant increase of the 2|Hso|S1>, 1|Hso|S1>, and 1|Hso|S0> spin–orbit coupling matrix elements. These phenomena lead to efficient radiationless deactivation of the lowest excited states of free-base porphyrin via intercombination conversion. In particular, the S1→T1 population transfer is found to proceed at a rate of ≈107 s−1 in the isolated molecule. 相似文献
68.
Salzmann S Kleinschmidt M Tatchen J Weinkauf R Marian CM 《Physical chemistry chemical physics : PCCP》2008,10(3):380-392
(Time-dependent) Kohn-Sham density functional theory and a combined density functional/multi-reference configuration interaction method (DFT/MRCI) were employed to explore the ground and low-lying electronically excited states of thiophene. Spin-orbit coupling was taken into account using an efficient, nonempirical mean-field Hamiltonian. Phosphorescence lifetimes were calculated by means of spock.ci, a selecting direct multi-reference spin-orbit configuration interaction program. Throughout this paper, we use the following nomenclature: S1, S2,..., T1, T2,..., denominate electronic structures in their energetic order at the ground state minimum geometry, whereas S1, S2,..., T1, T2,..., refers to the actual order of electronic states at a given nuclear geometry. Multiple minima were found on the first excited singlet (S1) potential energy hypersurface with electronic structures S1 (piHOMO-1-->pi+piHOMO-->pi), S2 (piHOMO-->pi), and S3 (piHOMO-->sigma*) corresponding to the 2 1A1 (S1), 1 1B2 (S2), and 1 1B1 (S3) states in the vertical absorption spectrum, respectively. The S1 and S2 minimum geometries show out-of-plane deformations of the ring. The S3 electronic structure yields the global minimum on the S1 surface with an adiabatic excitation energy of merely 3.81 eV. It exhibits an asymmetric planar nuclear arrangement with one significantly elongated C-S bond. A constrained minimum energy path calculation connecting the S1 and S3 minima suggests that even low-lying vibrational levels of the S1 potential well can access the global minimum of the S1 surface. Nonradiative decay of the electronically excited singlet population to the electronic ground state via a close-by conical intersection will be fast. According to our work, this ring opening mechanism is most likely responsible for the lack of fluorescence in thiophene and the ultrafast decay of the S1 vibrational levels, as observed in time-resolved pump-probe femtosecond multiphoton ionization experiments. An alternative relaxation pathway leads from the S1 minimum via vibronic coupling to the S2 potential well followed by fast inter-system crossing to the T2 state. For an estimate of individual rate constants a quantum dynamical treatment will be required. The global minimum of the T1 surface has a chair-like nuclear conformation and corresponds to the T1 (1 3B2, piHOMO-->pi) electronic structure. Phosphorescence is weak here with a calculated radiative lifetime of 0.59 s. For the second potential well on the T1 surface with T3 (1 3B1, piHOMO-->sigma*) electronic structure, nonradiative processes are predicted to dominate the triplet decay. 相似文献
69.
Berni E Dolain C Kauffmann B Léger JM Zhan C Huc I 《The Journal of organic chemistry》2008,73(7):2687-2694
The synthesis of various 1,8-diaza-4,5-dialkoxy-2,7-anthracene dicarboxylic acid derivatives and their incorporation into cyclic and helically folded aromatic oligoamides are reported. The ability of the diaza-anthracene monomers to undergo photoaddition or head-to-tail photodimerization was investigated in the solid state and in solution. Quantitative conversion of a monomer diester to the corresponding head-to-tail photodimer could be achieved in the solid state without protection from oxygen. The formation of an emissive excimer between two diaza-anthracene units appended at the end of a helically folded oligomer was demonstrated. Intramolecular photodimerization was not observed in this compound, possibly due to the low thermal stability of the head-to-head photoadduct. A cyclic oligoamide composed of two diaza-anthracene and two pyridine units was shown to adopt a flat conformation and to form columnar stacks in the solid state. Longer, noncyclic oligoamides composed of one or two diaza-anthracene units were shown to adopt helical conformations that exist preferentially as double helical dimers. 相似文献
70.
We present a simple increment model for use in the rapid scoring of hydrogen bond strengths employing 15 chemically diverse donor and 28 acceptor terms. The increments cover a large variety of hydrogen bond donor and acceptor groups and are more specific than SYBYL atom types. The increments have been fitted to quantum chemical ab initio interaction energies of 81 small hydrogen‐bonded complexes determined at the level of second‐order Møller‐Plesset perturbation theory (MP2). The complexes have been chosen such as to represent the most important types of donor‐acceptor pairs found in biological systems. Sulphur is found to be a strong hydrogen bond acceptor while its donor capacities are weak. By taking CH acidic H donors into account, a linear correlation between MP2 energies and the increment model with a coefficient of correlation of r2 = 0.994 has been accomplished. The transferability of the fitted parameters has been assessed on a second set of complexes including larger molecules of biological relevance. Very good agreement has been achieved for noncyclic hydrogen bonds. Cooperative effects are not accounted for by the current increment model. For this reason, binding energies of strong cyclic hydrogen bonds, as e.g. present in DNA base pairs, are underestimated by about 30–40%. © 2007 Wiley Periodicals, Inc. J Comput Chem, 2007 相似文献