The Synthesis,Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid

A novel two-dimensional copper(II) framework (LDU-1), formulated as {[Cu₂(L)₂·2NMP}n (H₂L = flavone-6,2′-dicarboxylic acid, NMP = N-Methyl pyrrolidone), has been constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-ray diffraction (PXRD). In the crystal structure, the Cu(II) shows hex-coordinated with the classical Cu paddle-wheel coordination geometry, and the flavonoid ligand coordinates with the Cu(II) ion in a bidentate bridging mode. Of particular interest of LDU-1 is the presence of anti-tumor activity against three human cancer cell lines including lung adenocarcinoma(A549), Michigan cancer foundation-7 (MCF-7), erythroleukemia (K562) and murine melanoma B16F10, indicating synergistic enhancement effects between metal ions and organic linkers. A cell cycle assay indicates that LDU-1 induces cells to arrest at S phase obviously at a lower concentration.     

Antibacterial Thiopeptide GE2270-Congeners from Nonomuraea jiangxiensis

Thiopeptides are macrocyclic natural products with potent bioactivity. Nine new natural thiopeptides (1–9) were obtained from a Nonomuraea jiangxiensis isolated from a terrestrial soil sample collected in Singapore. Even though some of these compounds were previously synthesized or isolated from engineered strains, herein we report the unprecedented isolation of these thiopeptides from a native Nonomuraea jiangxiensis. A comparison with the literature and a detailed analysis of the NMR and HRMS of compounds 1–9 was conducted to assign their chemical structures. The structures of all new compounds were highly related to the thiopeptide antibiotics GE2270, with variations in the substituents on the thiazole and amino acid moieties. Thiopeptides 1–9 exhibited a potent antimicrobial activity against the Gram-positive bacteria, Staphylococcus aureus with MIC₉₀ values ranging from 2 µM to 11 µM. In addition, all compounds were investigated for their cytotoxicity against the human cancer cell line A549, none of the compounds were cytotoxic.     

电子束发散角的直接测量技术模拟研究

切伦科夫辐射是一种方向性极好的辐射,其辐射能量发射方向严格地与带电粒子的运动方向相关,辐射光携带了带电粒子的方向信息,利用这种特性可以进行电子束发散角及其分布的测量。在基于切伦科夫辐射原理的基础上,考虑电子与物质作用时的多重库仑散射、电离等效应,进行了电子束发散角测量的蒙特卡罗数值模拟程序的建模工作,并完成了理想电子束及具有发散角分布的电子束的测量技术模拟工作。大量模拟结果显示,这种测量方法是可行的,具有对电子束发散角分布进行直接测量的能力,并且其测量系统结构简单。     

Diluting the Resistance of Built-in Electric Fields in Oxygen Vacancy-enriched Ru/NiMoO4-x for Enhanced Hydrogen Spillover in Alkaline Seawater Splitting

Recently, hydrogen spillover based binary (HSBB) catalysts have received widespread attention due to the sufficiently utilized reaction sites. However, the specific regulation mechanism of spillover intensity is still unclear. Herein, we have fabricated oxygen vacancies enriched Ru/NiMoO_4-x to investigate the internal relationship between electron supply and mechanism of hydrogen spillover enhancement. The DFT calculations cooperate with in situ Raman spectrum to uncover that the H* spillover from NiMoO_4-x to Ru. Meanwhile, oxygen vacancies weakened the electron supply from Ru to NiMoO_4-x, which contributes to dilute the resistance of built-in electric field (BEF) for hydrogen spillover. In addition, the higher ion concentration in electrolyte will promote the H* adsorption step obviously, which is demonstrated by in situ EIS tests. As a result, the Ru/NiMoO_4-x exhibits a low overpotential of 206 mV at 3.0 A cm⁻², a small Tafel slope of 28.8 mV dec⁻¹, and an excellent durability of 550 h at the current density of 0.5 A cm⁻² for HER in 1.0 M KOH seawater.     

Phototriggered color modulation of perovskite nanoparticles for high density optical data storage

Photoresponsive luminescent materials (PLMs) have attracted much attention in various optoelectronic fields, especially in optical data storage. Multi-wavelength (N-wavelength) based optical storage is a promising approach to increase the data storage density, but its current application is limited by the fact that most PLMs have only two-wavelength emissive states after certain light excitation, which requires simultaneous use of several PLMs and different irradiation light sources. In this study, we discovered that the wavelength of perovskite nanocrystals (PNCs) in the presence of dichloromethane (DCM) could be continuously and precisely tuned over a very wide color range (from red to violet) with the help of a single UV light source. The changes in crystal structures and optical properties of PNCs during UV irradiation were investigated in detail; the effects of capping ligand, solvent, UV irradiation power and time were evaluated, and the mechanism of UV triggered PNC fluorescence change was studied and is discussed. Finally, the applicability of PNCs/DCM film in N-wavelength-based high-density optical data storage was verified.

The perovskite nanocrystals-dichloromethane (PNCs-DCM) with tunable fluorescent color under UV light are a new kind of photoresponsive luminescent materials (PLMs), which are qualified to apply in optical data storage.     

Effects of Extraction Methods on the Bioactivities and Nutritional Value of Virginia and Valencia-Type Peanut Oil

This study aimed to evaluate the effects of peanut varieties cultivated in Morocco (Virginia and Valencia) and extraction methods (cold press, CP; Soxhlet, Sox and maceration, and Mac) on the fatty acid profile, phytosterol, and tocopherol contents, quality characteristics, and antioxidant potential of peanut seed oil. The DPPH method was used to determine the antioxidant activity of the oils. The results revealed that fatty acid content was slightly affected by the extraction technique. However, the CP method was shown to be an excellent approach for extracting oil with desirable quality features compared to the Sox and Mac methods. Furthermore, the peanut oil extracted via CP carried a higher amount of bioactive compounds and exhibited remarkable antioxidant activities. The findings also revealed higher oleic acid levels from the Virginia oil, ranging from 56.46% to 56.99%. Besides, a higher total phytosterol and tocopherol content and DPPH scavenging capacity were obtained from the Valencia oil. Analyzing the study, it can be inferred that extraction method and variety both affect the composition of the peanut oil’s bioactive compounds and antioxidant activity. This information is relevant for extracting peanut oil with a greater level of compounds of industrial interest.     

Sophorolipids—Bio-Based Antimicrobial Formulating Agents for Applications in Food and Health

Sophorolipids are well-known glycolipid biosurfactants, produced mainly by non-pathogenic yeast species such as Candida bombicola with high yield. Its unique environmental compatibility and high biodegradable properties have made them a focus in the present review for their promising applications in diverse areas. This study aims to examine current research trends of sophorolipids and evaluate their applications in food and health. A literature search was conducted using different research databases including PubMed, ScienceDirect, EBSCOhost, and Wiley Online Library to identify studies on the fundamental mechanisms of sophorolipids and their applications in food and health. Studies have shown that various structural forms of sophorolipids exhibit different biological and physicochemical properties. Sophorolipids represent one of the most attractive biosurfactants in the industry due to their antimicrobial action against both Gram-positive and Gram-negative microorganisms for applications in food and health sectors. In this review, we have provided an overview on the fundamental properties of sophorolipids and detailed analysis of their applications in diverse areas such as food, agriculture, pharmaceutical, cosmetic, anticancer, and antimicrobial activities.     

Identification of Protosappanoside D from Caesalpinia decapetala and Evaluation of Its Pharmacokinetic,Metabolism and Pharmacological Activity

Protosappanoside D (PTD) is a new component isolated from the extract of Caesalpinia decapetala for the first time. Its structure was identified as protosappanin B-3-O-β-D-glucoside by ¹H-NMR, ¹³C-NMR, 2D-NMR and MS techniques. To date, the pharmacological activities, metabolism or pharmacokinetics of PTD has not been reported. Therefore, this research to study the anti-inflammatory activity of PTD was investigated via the LPS-induced RAW264.7 cells model. At the same time, we also used the UHPLC/Q Exactive Plus MS and UPLC-MS/MS methods to study the metabolites and pharmacokinetics of PTD, to calculate its bioavailability for the first time. The results showed that PTD could downregulate secretion of the pro-inflammatory cytokines. In the metabolic study, four metabolites were identified, and the primary degradative pathways in vivo involved the desaturation, oxidation, methylation, alkylation, dehydration, degradation and desugarization. In the pharmacokinetic study, PTD and its main metabolite protosappanin B (PTB) were measured after oral and intravenous administration. After oral administration of PTD, its T_max was 0.49 h, t_1/2z and MRT_(0–t) were 3.47 ± 0.78 h and 3.06 ± 0.63 h, respectively. It shows that PTD was quickly absorbed into plasma and it may be eliminated quickly in the body, and its bioavailability is about 0.65%.