Accelerated passive MR catheter tracking into the carotid artery of canines

Background

Using magnetic resonance (MR) imaging for navigating catheters has several advantages when compared with the current “gold standard” modality of X-ray imaging. A significant drawback to interventional MR is inferior temporal and spatial resolutions, as high spatial resolution images cannot be collected and displayed at rates equal to X-ray imaging. In particular, passive MR catheter tracking experiments that use positive contrast mechanisms have poor temporal imaging rates and signal-to-noise ratio. As a result, with passive methods, it is often difficult to reconstruct motion artifact-free tracking images from areas with motion, such as the thoracic cavity.

Methods

In this study, several accelerated MR acquisition strategies, including parallel imaging and compressed sensing (CS), were evaluated to determine which method is most effective at improving the frame rate and passive detection of catheters in regions of physiological motion. Device navigation was performed both in vitro, through the aortic arch of an anthropomorphic chest phantom, and in vivo from the femoral artery, up the descending aorta into the supra-aortic branching vessels in canines.

Results and Discussion

The different parallel imaging methods produced images of low quality. CS with a two-fold acceleration was found to be the most effective method for generating tracking images, improving the image frame rate to 5.2 Hz, while maintaining a relatively high in-plane resolution. Using CS, motion artifact was decreased and the catheters were visualized with good conspicuity near the heart.

Conclusions

The improvement in the imaging frame rate by image acceleration was sufficient to overcome motion artifacts and to better visualize catheters in the thoracic cavity with passive tracking. CS preformed best at tracking. Navigation with passive MR catheter tracking was demonstrated from the femoral artery to the carotid artery in canines.     

The Infrared and 1H-NMR Spectra of 8-Hydroxyquinoline Adducts of 8-Hydroxyquinoline Complexes of Dioxouranium(VI), Thorium(IV) and Scandium(III)

The ¹H-nmr and infrared spectra of the complexes [M(ox)_n(Hox)] where M = UO₂ (n = 2), Th (n = 4) or Sc (n = 3) and Hox = 8-hydroxyquinoline are discussed. The nmr spectra of the adducts are uninformative with respect to the bonding and structure of these molecules since they dissociate in solution. The solid state ir spectra show that the adducted molecule of 8-hydroxyquinoline is bound to the metal through the phenolic oxygen, the proton forming an intramolecular hydrogen bond between the nitrogen atom of the adducted molecule and the oxygen atom of a neighbouring chelate ring. The mid-and far-ir spectra are reported for the first time and assignments for the δN-H, νM-O and νM-N modes have been made.     

Impact of intravenous nicotine on BOLD signal response to photic stimulation

Functional magnetic resonance imaging (fMRI) is increasingly being applied in the study of brain effects of nicotine. In addition, because tobacco smoking is common, many subjects studied with fMRI for other reasons may have appreciable levels of nicotine in plasma and brain during scanning. However, there is concern that the vascular effects of nicotine may alter the coupling between blood oxygen level dependent (BOLD) signal and neuronal activity. The objective of this study was to test for evidence of alteration of BOLD signal response of occipital cortex, a region with a relatively low concentration of neuronal nicotine receptors, to photic stimulation during intravenous infusion of nicotine. Nine nicotine dependent healthy smokers were withdrawn from nicotine under controlled conditions and then scanned while receiving photic stimulation and successive intravenous infusions of saline and nicotine. No evidence for an effect of nicotine on BOLD signal response to photic stimulation was detected at the doses studied. This observation suggests that nicotine does not alter the coupling between BOLD signal and neuronal activity in the visual cortex.     

Investigation at the chain segmental level of the miscibility of poly(vinyl chloride)/atactic poly(methyl methacrylate) blends

We employed high‐resolution ¹³C cross‐polarization/magic‐angle‐spinning/dipolar‐decoupling NMR spectroscopy to investigate the miscibility and phase behavior of poly(vinyl chloride) (PVC)/poly(methyl methacrylate) (PMMA) blends. The spin–lattice relaxation times of protons in both the laboratory and rotating frames [T₁(H) and T_1ρ(H), respectively] were indirectly measured through ¹³C resonances. The T₁(H) results indicate that the blends are homogeneous, at least on a scale of 200–300 Å, confirming the miscibility of the system from a differential scanning calorimetry study in terms of the replacement of the glass‐transition‐temperature feature. The single decay and composition‐dependent T_1ρ(H) values for each blend further demonstrate that the spin diffusion among all protons in the blends averages out the whole relaxation process; therefore, the blends are homogeneous on a scale of 18–20 Å. The microcrystallinity of PVC disappears upon blending with PMMA, indicating intimate mixing of the two polymers. © 2001 John Wiley & Sons, Inc. J Polym Sci Part B: Polym Phys 39: 2390–2396, 2001     

Finite line-transitive linear spaces: Theory and search strategies

The paper summarises existing theory and classifications for finite line-transitive linear spaces, develops the theory further, and organises it in a way that enables its effective application. The starting point is a theorem of Camina and the fifth author that identifies three kinds of line-transitive automorphism groups of linear spaces. In two of these cases the group may be imprimitive on points, that is, the group leaves invariant a nontrivial partition of the point set. In the first of these cases the group is almost simple with point-transitive simple socle, and may or may not be point-primitive, while in the second case the group has a non-trivial point-intransitive normal subgroup and hence is definitely point-imprimitive. The theory presented here focuses on point-imprimitive groups. As a non-trivial application a classification is given of the point-imprimitive, line-transitive groups, and the corresponding linear spaces, for which the greatest common divisor gcd（k, v - 1） ≤ 8, where v is the number of points, and k is the line size. Motivation for this classification comes from a result of Weidong Fang and Huffing Li in 1993, that there are only finitely many non-trivial point-imprimitive, linetransitive linear spaces for a given value of gcd（k, v - 1）. The classification strengthens the classification by Camina and Mischke under the much stronger restriction k ≤ 8： no additional examples arise. The paper provides the backbone for future computer-based classifications of point-imprimitive, line- transitive linear spaces with small parameters. Several suggestions for further investigations are made.     

Generalized Quadrangles and Transitive Pseudo‐Hyperovals

A pseudo‐hyperoval of a projective space , q even, is a set of subspaces of dimension such that any three span the whole space. We prove that a pseudo‐hyperoval with an irreducible transitive stabilizer is elementary. We then deduce from this result a classification of the thick generalized quadrangles that admit a point‐primitive, line‐transitive automorphism group with a point‐regular abelian normal subgroup. Specifically, we show that is flag‐transitive and isomorphic to , where is either the regular hyperoval of PG(2, 4) or the Lunelli–Sce hyperoval of PG(2, 16).