A mathematical model of aging-related and cortisol induced hippocampal dysfunction

Background  

The hippocampus is essential for declarative memory synthesis and is a core pathological substrate for Alzheimer's disease (AD), the most common aging-related dementing disease. Acute increases in plasma cortisol are associated with transient hippocampal inhibition and retrograde amnesia, while chronic cortisol elevation is associated with hippocampal atrophy. Thus, cortisol levels could be monitored and managed in older people, to decrease their risk of AD type hippocampal dysfunction. We generated an in silicomodel of the chronic effects of elevated plasma cortisol on hippocampal activity and atrophy, using the systems biology mark-up language (SBML). We further challenged the model with biologically based interventions to ascertain if cortisol associated hippocampal dysfunction could be abrogated.     

Definition and measurement of the normalized electrical impedance of lossy piezoelectric resonators for ultrasonic transducers

Relevant equivalent circuit parameters and values of material constants of a piezoelectric resonator can be determined from measurements of its electrical input impedance as a function of frequency. The complex electrical impedance curves and the associated critical frequencies are the basis of this characterization by the piezoelectric resonance method. In this paper, the previously introduced concept of normalized electrical impedance of the lossy resonator, extended to include piezoelectric losses, is applied to the analysis of the effects of different types of intrinsic losses on peak values, bandwidths and characteristic frequencies. The resulting impedance patterns depend solely on the electromechanical coupling coefficient and the loss tangents, providing a useful tool for the analysis of low-Q resonators. The normalized impedance is experimentally evaluated from the basic data provided by an HP 4194A impedance analyser by means of specifically developed ASP programs.     

Au-nanoparticles grafted on plasma treated PE

Polyethylene (PE) surface was treated with Ar plasma. Activated surface was grafted from methanol solution of 1,2-ethanedithiol. Then the sample was immersed into freshly prepared colloid solution of Au-nanoparticles. Finally Au layer was sputtered on the samples. Properties of the modified PE were studied using various methods: AFM, EPR, RBS and nanoindentation. It was shown that the plasma treatment results in degradation of polymer chain (AFM) and creation of free radicals by EPR. After grafting with dithiol, the concentration of free radicals declines. The presence of Au and S in the surface layer after the coating with Au-nanoparticles was proved by RBS. Plasma treatment changes PE surface morphology and increases surface roughness, too. Another significant change in surface morphology and roughness was observed after deposition of Au-nanoparticles. Nanoindentation measurements show that the grafting with Au-nanoparticles increases adhesion of subsequently sputtered Au layer.     

Are hepatic and muscle T2 values different at 0.5 and 1.5 Tesla?

In an effort to determine whether T2 values of liver and muscle change with increasing field strength, 144 abdominal MR examinations were retrospectively evaluated. These patients were evaluated with a dual echo T2-weighted spin-echo sequence. Eighty-two of the examinations were performed at 0.5 Tesla and 72 at 1.5 Tesla (T). Eleven of the patients were evaluated with both MR systems with the same sequences. T2 values were also obtained from a Fe NH4(SO4)2 12H2O phantom. The T2 values of liver decreased from 57.8 +/- 11.3 at 0.5 T to 43.7 +/- 8.3 at 1.5 T. The T2 values of muscle decreased from 44.2 +/- 9 at 0.5 T to 35.4 +/- 7.2 at 1.5 T. Patients who were examined on both systems also demonstrated a decrease in both liver and muscle T2 values. For concentrations in the range of hepatic T2's, the phantom demonstrated a decrease in T2 values from 0.5 to 1.5 T ranging from 20.3 to 23.4%. All the T2 changes were statistically significant (p less than .05). The findings suggest that T2 values may depend on field strength, or may vary due to other hardware-related differences.     

Письма в редакцию ГЕОМАГНИТНЫЙ ЭФФЕКТ ШИРОКИХ ЛИВНЕЙ КОСМИ ЧЕСКИХ ЛУЧЕЙ

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Geomagnetic effect of extensive airshowers produced by cosmic rays

     

Production and decay angular distributions of the Y1 (1385) in the line-reversed reactions: π+p → K+Y1 (1385) and K−p → π−Y1 (1385) at 11.5 GeV/c

We have measured in a single experimental setup, the differential cross sections and decay angular distributions of the Y¹ (1385) produced in the two line-reversed reactions: $\text{π}{}^{\mathrm{+}}\text{p}\text{→}\text{K}{}^{\mathrm{+}}\text{Y}{}^{\mathrm{1+}}\text{(1385) (279}\text{events/ω}\text{b}\text{)}\text{and K}{}^{\mathrm{?}}\text{p}\text{→ π}{}^{\mathrm{?}}\text{Y}{}^{\mathrm{1+}}\text{(1385)}$ (190 events/ωb) at 11.5 GeV/c. The data have been derived from a triggered bubble-chamber experiment using the SLAC Hybrid Facility. We find the differential cross sections and Y¹ polarizations for the two reactions to be in agreement with exchange-degeneracy predictions, if kinematic differences are taken into account. The Stodolsky-Sakurai and additive quark model predictions are in agreement with the main features of the decay angular distributions of the Y¹ (1385), except for small violations at low momentum transfer, which can be associated with a finite helicity non-flip contribution in the forward direction.     

ГЕОМАГНИТНЫЙ ЭФФЕКТ ШИРОКИХ ЛИВНЕЙ КОСМИ ЧЕСКИХ ЛУЧЕЙ

( - .). , - , - , - . , D=30 40% , ; D=50 60%. .     

Multistrange baryon production in Au-Au collisions at sqrt[s(NN)]=130 GeV

The transverse mass spectra and midrapidity yields for Xis and Omegas are presented. For the 10% most central collisions, the (-)Xi(+)/h(-) ratio increases from the Super Proton Synchrotron to the Relativistic Heavy Ion Collider energies while the Xi(-)/h(-) stays approximately constant. A hydrodynamically inspired model fit to the Xi spectra, which assumes a thermalized source, seems to indicate that these multistrange particles experience a significant transverse flow effect, but are emitted when the system is hotter and the flow is smaller than values obtained from a combined fit to pi, K, p, and Lambdas.     

Measurement of transverse single-spin asymmetries for Dijet production in proton-proton collisions at sqrt[s]=200 GeV

We report the first measurement of the opening angle distribution between pairs of jets produced in high-energy collisions of transversely polarized protons. The measurement probes (Sivers) correlations between the transverse spin orientation of a proton and the transverse momentum directions of its partons. With both beams polarized, the wide pseudorapidity (-1< or = eta < or = +2) coverage for jets permits separation of Sivers functions for the valence and sea regions. The resulting asymmetries are all consistent with zero and considerably smaller than Sivers effects observed in semi-inclusive deep inelastic scattering. We discuss theoretical attempts to reconcile the new results with the sizable transverse spin effects seen in semi-inclusive deep inelastic scattering and forward hadron production in pp collisions.