Flag-dipole and flagpole spinor fluid flows in Kerr spacetimes

Flagpole and flag-dipole spinors are particular classes of spinor fields that has been recently used in different branches of theoretical physics. In this paper, we study the possibility and consequences of these spinor fields to induce an underlying fluid flow structure in the background of Kerr spacetimes. We show that flag-dipole spinor fields are solutions of the equations of motion in this context. To our knowledge, this is the second time that this class of spinor field appears as a physical solution, the first one occurring as a solution of the Dirac equation in ESK gravities.     

Bell inequalities for continuous-variable correlations

We derive a new class of correlation Bell-type inequalities. The inequalities are valid for any number of outcomes of two observables per each of n parties, including continuous and unbounded observables. We show that there are no first-moment correlation Bell inequalities for that scenario, but such inequalities can be found if one considers at least second moments. The derivation stems from a simple variance inequality by setting local commutators to zero. We show that above a constant detector efficiency threshold, the continuous-variable Bell violation can survive even in the macroscopic limit of large n. This method can be used to derive other well-known Bell inequalities, shedding new light on the importance of non-commutativity for violations of local realism.     

Selection of antileishmanial sesquiterpene lactones from SistematX database using a combined ligand-/structure-based virtual screening approach

Molecular Diversity - Leishmaniasis refers to a complex of diseases, caused by the intracellular parasitic protozoans belonging to the genus Leishmania. Among the three types of disease...     

Pharmacological Approaches to the Treatment of Dementia in Down Syndrome: A Systematic Review of Randomized Clinical Studies

Down Syndrome (DS) is considered the most frequent form of Intellectual Disability, with important expressions of cognitive decline and early dementia. Studies on potential treatments for dementia in this population are still scarce. Thus, the current review aims to synthesize the different pharmacological approaches that already exist in the literature, which focus on improving the set of symptoms related to dementia in people with DS. A total of six studies were included, evaluating the application of supplemental antioxidant therapies, such as alpha-tocopherol; the use of acetylcholinesterase inhibitor drugs, such as donepezil; N-methyl-d-aspartate (NMDA) receptor antagonists, such as memantine; and the use of vitamin E and a fast-acting intranasal insulin. Two studies observed important positive changes related to some general functions in people with DS (referring to donepezil). In the majority of studies, the use of pharmacological therapies did not lead to improvement in the set of symptoms related to dementia, such as memory and general functionality, in the population with DS.     

Immunomodulatory Response of Mice Splenocytes Induced by RcaL, a Lectin Isolated from Cobia Fish (Rachycentron canadum) Serum

This work reports the isolation of a serum lectin from cobia fish (Rachycentron canadum) named RcaL. Immunomodulatory activity on mice splenocyte experimental cultures through cytotoxic assays and cytokine production were also performed. RcaL was obtained through precipitation with ammonium sulphate and affinity chromatography on a Concanavalin A-Sepharose 4B column. The ammonium sulphate fraction F3 showed the highest specific hemagglutinating activity and was applied to affinity chromatography. The lectin was eluted with methyl-α-d-mannopyranoside. RcaL showed highest affinity for methyl-α-d-mannopyranoside and d-mannose; eluted fractions of RcaL agglutinated rabbit erythrocytes (titre, 128^?1) retained 66 % of chromatographed lectin activity, and the obtained purification factor was 1.14. Under reducing conditions, a polypeptide band of 19.2 kDa was revealed in sodium dodecyl sulphate polyacrylamide gel electrophoresis (PAGE). PAGE confirmed RcaL as an acidic protein revealed in a single band. Cytotoxic and immunomodulatory assays with RcaL in mice splenocyte cultures showed that the lectin was not cytotoxic and induced higher interferon gamma and nitric oxide production in splenocyte cultures. Purified RcaL induced preferential Th1 response, suggesting that it acts as an immunomodulatory compound.     

Non-specific interactions of CdTe/Cds Quantum Dots with human blood mononuclear cells

In order to study biological events, researchers commonly use methods based on fluorescence. These techniques generally use fluorescent probes, commonly small organic molecules or fluorescent proteins. However, these probes still present some drawbacks, limiting the detection. Semiconductor nanocrystals - Quantum Dots (QDs) - have emerged as an alternative tool to conventional fluorescent dyes in biological detection due to its topping properties - wide absorption cross section, brightness and high photostability. Some questions have emerged about the use of QDs for biological applications. Here, we use optical tools to study non-specific interactions between aqueous synthesized QDs and peripheral blood mononuclear cells. By fluorescence microscopy we observed that bare QDs can label cell membrane in live cells and also label intracellular compartments in artificially permeabilized cells, indicating that non-specific labeling of sub-structures inside the cells must be considered when investigating an internal target by specific conjugation. Since fluorescence microscopy and flow cytometry are complementary techniques (fluorescence microscopy provides a morphological image of a few samples and flow cytometry is a powerful technique to quantify biological events in a large number of cells), in this work we also used flow cytometry to investigate non-specific labeling. Moreover, by using optical tweezers, we observed that, after QDs incubation, zeta potentials in live cells changed to a less negative value, which may indicate that oxidative adverse effects were caused by QDs to the cells.     

On existence, uniform decay rates and blow up for solutions of the 2-D wave equation with exponential source

This paper is concerned with the study of the nonlinear damped wave equation

Driving-dependent damping of Rabi oscillations in two-level semiconductor systems

We propose a mechanism to explain the nature of the damping of Rabi oscillations with an increasing driving-pulse area in localized semiconductor systems and have suggested a general approach which describes a coherently driven two-level system interacting with a dephasing reservoir. Present calculations show that the non-Markovian character of the reservoir leads to the dependence of the dephasing rate on the driving-field intensity, as observed experimentally. Moreover, we have shown that the damping of Rabi oscillations might occur as a result of different dephasing mechanisms for both stationary and nonstationary effects due to coupling to the environment. Present calculated results are found in quite good agreement with available experimental measurements.     

Existence and decay rate estimates for the wave equation with nonlinear boundary damping and source term

The wave equation with a source term is considered