Adjuvant Effects of Dual Co-stimulatory Molecules on Cellular Responses to HIV Multiple-epitope DNA Vaccination

Designing adjuvants that can induce strong cytotoxic T cell responses is largely required for preparing DNA vaccines. In this study we explored dual costimulatory molecules 4-1BBL and OX40L as adjuvants to improve the efficiency of the HIV multiple-epitope DNA vaccine. When explored in the human dendritic cell-T cell based coculture system,dual costimulatory molecules significantly enhanced the anti-HIV T cell response of the HIV mul-tiple-epitope DNA vaccine,as detected by intracellular cytokine staining t...     

Microwave-assisted one-pot synthesis of 3-substituted-3,4-dihydrocoumarins via tendem Konevenagel and Hantzsch reactions

A convenient route for the synthesis of 3,4-dihydrocoumarin derivates from salicylaldehyde derivates and 1,3-dicarbonyl compounds under solvent-free microwave irradiation conditions was described. In this way, a range of compounds was obtained in moderate to good yields in a short reaction time.     

渐近φ伪压缩映象有限族的迭代程序的强收敛(英文)

Strong convergence theorems for approximation of common fixed points of asymptoticallyφ-quasi-pseudocontractive mappings and asymptoticallyφ-strictly- pseudocontractive mappings are proved in real Banach spaces by using a new compos- ite implicit iteration scheme with errors.The results presented in this paper extend and improve the main results of Sun,Gu and Osilike published on J.Math.Anal. Appl.     

A ONE-STEP EXPLICIT FORMULA FOR THE NUMERICAL SOLUTION OF STIFF ORDINARY DIFFERENTIAL EQUATION

In this paper, a new one-step explicit method of fourth order is derived. The new method is proved to be A-stable and L-stable, and it gives exact results when applied to the test equation y'=λy with Re(λ)<0, Also several numerical examples are included.     

Synthesis of new chiral 1,2,3,4-tertrahydroisoquinoline β-amino alcohol for asymmetric diethylzinc addition to aryl aldehydes(Ⅰ)

Four new chiral 1,2,3,4-tetrahydroisoquinoline-derived β-amino alcohols were synthesized from commercially available L-DOPA. These ligands were evaluated in the asymmetric addition of diethylzinc to benzaldehydes and showed different catalytic activities(up to 86%ee).The solvent played an important role in the enantioselective process.The transition state models were proposed to explain the reversion of the product configuration.     

强流相对论电子束的数值模拟

我们研制了CEBQ程序和ENVLOP程序，模拟稳态相对论电子束在二极管区的产生和加速，以及电子束在阳极通道内的传输过程。CEBQ程序模拟二极管区电子轨道，当阳极电压为1．5MV时，阴极总发射电流为17．9kA，进入阳极通道内的传输电流为4．3kA，阳极入口处D=4cm的束发射度为24．9cm．mrad。ENVLOP程序使用线性近似下的包络方程，描述电子束包络在螺旋管引导磁场作用下的变化，讨论了外加引导磁场对包络的影响。计算结果表明，在合适引导磁场作用下，束包络起伏较小，进入阳极通道的束流(4．3kA)能全部通过。     

毫米波圆柱波导自由电子激光放大器的数值模拟

本文以单粒子理论为基础，在不计空间电荷效应的近似条件下推导了带轴向引导磁场的三维圆柱波导非线性模拟方程组。用CAGFEL程序计算、分析了在带入口区、常数摇摆器条件下两组不同物理参数的自由电子激光放大器的物理模型。计算结果可靠，物理图象合理。对于其中的第二组参数还着重考查了光波频率、输入功率和摇摆器场振幅改变对输出功率和效率的影响。上述这些计算结果对0．7MeV 自由电子激光放大器的设计和实验具有一定的参考价值。     

聚合物侧基NMR弛豫相关函数

本文导出了聚合物为链段运动时,侧基进行非等价二位置和三位置跃迁内旋转、随机自由扩散内旋转以及受阻内旋转时的NMR弛豫相关函数,同时给出了相应的谱密度函数,并讨论了两个应用实例。     

LIA组元的脉冲功率调制系统研制

本文介绍一种以加速组元为终端负载的纳秒脉冲功率系统。获得的加速间隙电压为350kV，90ns(半高宽)，波形上升时间为30ns；Blumlein主开关工作电压大于280kV，抖动小予1.5ns(均方根值)。对同轴场畸变开关性能的进一步改善作了必要的讨论，提出了用等场强原则偏置触发极，比通常采用自然中位面方法，可使开关工作电压提高8．7％。