排序方式: 共有173条查询结果,搜索用时 31 毫秒
171.
Carina A. Valenzuela Ella J. Baker Camila O. De Souza Elizabeth A. Miles Philip C. Calder 《Molecules (Basel, Switzerland)》2021,26(19)
Endothelial dysfunction and inflammation are recognised factors in the development of atherosclerosis. Evidence suggests that intake of industrial trans fatty acids (TFAs) promotes endothelial dysfunction, while ruminant TFAs may have the opposite effect. The aim of this study was to compare the effects of elaidic acid (EA (18:1n-9t); an industrially produced TFA) and trans vaccenic acid (TVA (18:1n-7t); a natural TFA found in ruminant milk and meat) on inflammatory responses of endothelial cells (ECs). ECs (EA.hy926 cells) were cultured under standard conditions and exposed to TFAs (1 to 50 μM) for 48 h. Then, the cells were cultured for a further 6 or 24 h with tumour necrosis factor alpha (TNF-α, 1 ng/mL) as an inflammatory stimulant. ECs remained viable after treatments. TFAs were incorporated into ECs in a dose-dependent manner. Preincubation with EA (50 µM) increased production of MCP-1, RANTES, and IL-8 in response to TNF-α, while preincubation with TVA (1 µM) decreased production of ICAM-1 and RANTES in response to TNF-α. Preincubation with EA (50 µM) upregulated toll-like receptor 4 and cyclooxygenase 2 gene expression in response to TNF-α. In contrast, preincubation with TVA (1 µM) downregulated TNF-α induced nuclear factor kappa B subunit 1 gene expression. Preincubation of ECs with EA (50 µM) increased THP-1 monocyte adhesion. In contrast, preincubation of ECs with TVA (1 µM) reduced THP-1 monocyte adhesion, while preincubation of ECs with TVA (50 µM) decreased the level of surface expression of ICAM-1 seen following TNF-α stimulation. The results suggest that TVA has some anti-inflammatory properties, while EA enhances the response to an inflammatory stimulus. These findings suggest differential effects induced by the TFAs tested, fitting with the idea that industrial TFAs and ruminant TFAs can have different and perhaps opposing biological actions in an inflammatory context. 相似文献
172.
Tiago Alves Castro Bruna Santos Leite Larissa Santos Assuno Tayane de Jesus Freitas Nelson Barros Colauto Giani Andrea Linde Deborah Murowaniecki Otero Bruna Aparecida Souza Machado Camila Duarte Ferreira Ribeiro 《Molecules (Basel, Switzerland)》2021,26(23)
Most dyes used in the food industry are synthetic and can be a health hazard. Red tomato may serve as a natural alternative dye to replace synthetic colorants. This study aimed to review the literature on the addition of red tomato products (powder tomato, paste, freeze-dried, tomato peel powder, tomato pomace) to reduce the usage of synthetic dyes in the food industry. Red tomato products have been used as coloring in pasta, bologna, sausages, cookies, crackers, macaroons, hamburgers, breads, muffins, cheeses, and nuggets. The trans-cis isomerization of lycopene by oxidative processes directly affects the color of the pigment. The lycopene contained in tomato has antioxidant activity and could reduce or eliminate other oxidants and/or synthetic preservatives in food. Moreover, tomatoes in foods have high sensory scores, nutritional appeal, and marketing potential. However, its use as a food colorant has been not extensively explored. Therefore, further studies are still required, especially on the stability of carotenoids in tomatoes used in processed foods. 相似文献
173.
Camila C. Soares Angel E. Obispo Andrés G. Jirón Vicente Luis B. Castro 《Annalen der Physik》2023,535(5):2200258
In the present work, the relativistic quantum motion of massless fermions in a helicoidal graphene nanoribbon under the influence of a uniform magnetic field is investigated. Considering a uniform magnetic field (B) aligned along the axis of helicoid, this problem is explored in the context of Dirac equation in a curved space-time. As this system does not support exact solutions due to considered background, the bound-state solutions and local density of states (LDOS) are obtained numerically by means of the Numerov method. The combined effects of width of the nanoribbon (D), length of ribbon (L), twist parameter (ω), and B on the equations of motion and LDOS are analyzed and discussed. It is verified that the presence of B produces a constant minimum value of local density of state on the axis of helicoid, which is possible only for values large enough of ω, in contrast to the case for already studied in the literature. 相似文献