Double gradient ion chromatography on a short carboxybetaine coated monolithic anion exchanger

An ultra-short 1.0 x 0.46 cm carboxybetaine coated monolithic anion exchanger has been used with a new double gradient ion chromatography (DG-IC) technique. The novel monolithic column can be used with flow rate gradients giving excellent peak efficiencies, and retention times can be simultaneously reduced through combining flow gradients with an eluent pH gradient.     

Synthesis of unsymmetrical 4,6-diarylpyrimidines

Unsymmetrical 4,6-diarylpyrimidines were synthesized using Suzuki coupling reaction via selective arylation of 4,6-dichloropyrimidine.     

Anatoxins and degradation products, determined using hybrid quadrupole time-of-flight and quadrupole ion-trap mass spectrometry: forensic investigations of cyanobacterial neurotoxin poisoning

The potent neurotoxins from cyanobacteria, anatoxin-a (AN), its methyl analogue, homoanatoxin-a (HMAN), and their degradation products, have been studied using nano-electrospray hybrid quadrupole time-of-flight mass spectrometry (QqTOF-MS). The anatoxin degradation products, which are readily produced in vivo by either reduction or epoxidation, were also examined in this study. The high mass accuracy QqTOF-MS data was used to confirm formula assignments for major product ions and quadrupole ion-trap (QIT)-MS was used to construct fragmentation pathways for anatoxins. Significant differences between these fragmentation pathways were observed. Comparisons between the spectra of compounds that differ in side-chain length (the AN and HMAN series) were used to identify ions that are characteristic of the homologues. The application to forensic samples in which the principal neurotoxin had undergone rapid biodegradation has been demonstrated and used to confirm anatoxin poisoning of dogs.     

Fast ion chromatography of inorganic anions and cations on a lysine bonded porous silica monolith

A 0.46 cm x 10.0 cm silica monolith column was modified through the in situ covalent attachment of lysine (2,6-diaminohexanoic acid) groups. Due to the zwitterionic nature of the resultant stationary phase, the modified monolithic column contained both cation and anion exchange capacity. In the case of cation exchange, the capacity was found to be relatively low at between 5 and 6.5 micromoles Me2+ per column. However, as expected, the lysine monolith exhibited a higher anion exchange capacity at 12-13 micromoles A- per column (at pH 3.0), which was found to be dependent upon column pH, due to the dissociation of the weak acid carboxylic acid groups. High-performance separations of transition metal cations and inorganic anions were achieved using the modified monolith, with the effects of eluent concentration, pH and flow rate evaluated. Using elevated flow rates of up to 5 mL/min the separation of nitrite, bromate, bromide, nitrate, iodide and thiocyanate was possible in approximately 100 s with peak efficiencies of between 50 and 100,000 N/m and retention time %RSD of under 0.3%.     

Taking a little off the top: nanorod array morphology and growth studied by focused ion beam tomography

The high surface area, large aspect ratio, and porous nature of nanorod arrays make them excellent foundation materials for many devices. Of the many synthesis techniques for forming nanorods, glancing angle deposition (GLAD) offers one of the more straightforward and flexible methods for ensuring control of alignment, porosity, and architecture of the nanorods. Here we demonstrate the first use of a dual-beam (focused ion beam (FIB) combined with scanning electron microscopy (SEM)) instrument to section and image the internal morphology of a nanorod array fabricated using the GLAD technique. We have used the FIB-SEM to reconstruct the 3D composition of TiO(2) nanorods, allowing us to visualize for the first time the core structures of many potential devices. We have also been able to probe the relationship between critical parameters such as diameter (w(act)), internanorod spacing (ν(act)), center-to-center spacing (c(act)), and nanorod population density (d(act)) and the depth of the nanocolumn (t) for a single homogeneous structure. A continuous data set was obtained from a single 5-μm-thick GLAD film, avoiding the artifacts arising from the analysis of the top surfaces of multiple samples of varying thicknesses. An analysis of the acquired sectioned data has allowed us to determine that the critical nanocolumn parameters follow a power-law scaling trend with w(act) = 9.4t(0.35) nm, ν(act) = 15.2t(0.25) nm, c(act) = 24.8t(0.31) nm, and d(act) = 3402t(-0.65) columns μm(-2). Using the FIB/SEM images acquired for the TiO(2) nanorods, we have also investigated the evolution of individual nanocolumns and have observed that bifurcation and branching play a significant role in the extinction or survival of these nanorods. These findings will allow for the optimization of nanorod properties for device applications. Also, the FIB sectioning and reconstruction process developed here will permit for the investigation of nanorod arrays formed from a range of synthesis techniques and materials.     

A multiligand based Pd catalyst for C-N cross-coupling reactions

An alternative approach to catalyst development, which led to a Pd catalyst based on two biarylphosphine ligands for C-N cross-coupling reactions, is reported. By effectively being able to take the form of multiple catalysts this system manifests the best properties that catalysts based on either of the two ligands exhibit separately and displays the highest reactivity and substrate scope of any system that has been reported to date for these reactions.     

Optical guided waves at graded metal-dielectric interfaces

Waveguides at interfaces with a linearly graded permittivity between a metal and a dielectric are studied. Analytic expressions for the dispersion relations, modes, losses, and cutoff wavelengths are derived and agree well with simulations. The gradation results in anomalous dispersion, a reduction in the energy velocity, and increased field confinement in the metal-dielectric transition region. These effects lead to increased propagation losses, which are sensitive to the spatial extent of the interface gradation.     

Dynamics of effort allocation and evolution of trust: an agent-based model

Trust is a dynamic and complex phenomenon and understanding the factors which affect its formation, evolution and disappearance is a critical research issue. It has been shown that trust plays a key role in how human and social capital develop, how economies grow and how societies progress. In this paper, we present an agent-based model of the relations between a dynamic effort allocation system, an evolving trust framework and a reputation module to study how changes in micro-level rent-seeking traits and decisions can shape the emergence of trust across the simulated environment. According to our results, variations in trust are correlated more with the returns to being productive, rather than rent-seeking. In line with previous studies, our model shows that higher than average levels of risk-taking by agents lead to further trust and gains during an interaction, though taken to an extreme, both trust and gain can decline as a result of reckless decisions. We also report on the formation of trust clusters in our model as an emergent phenomenon.     

Exploded manifolds

This paper provides an introduction to exploded manifolds. The category of exploded manifolds is an extension of the category of smooth manifolds with an excellent holomorphic curve theory. Each exploded manifold has a tropical part which is a union of convex polytopes glued along faces. Exploded manifolds are useful for defining and computing Gromov–Witten invariants relative to normal crossing divisors, and using tropical curve counts to compute Gromov–Witten invariants.