Route stability in vehicle routing decisions: a bi-objective approach using metaheuristics

In this paper, we argue that vehicle routing solutions are often tactical decisions, that should not be changed too often or too much. For marketing or other reasons, vehicle routing solutions should be stable, i.e. a new solution (when e.g. new customers require service) should be as similar as possible to a solution already in use. Simultaneously however, this new solution should still have a good quality in the traditional sense (e.g. small total travel cost). In this paper, we develop a way to measure the difference between two vehicle routing solutions. We use this distance measure to create a metaheuristic approach that will find solutions that are “close” (in the solution space) to a given baseline solution and at the same time have a high quality in the sense that their total distance traveled is small. By using this approach, the dispatcher is offered a choice of Pareto-optimal solutions, allowing him to make a trade-off between changing his existing solution and allowing a longer travel distance. Some experiments are performed to show the effectiveness of the approach.     

A finite cutting plane method for facial disjunctive programs

This paper shows that any linear disjunctive program with a finite number of constraints can be transformed into an equivalent facial program. Based upon linear programming technique, a new, finite cutting plane method is presented for the facial programs.

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Zusammenfassung Die Arbeit zeigt, daß jedes lineare disjunktive Optimierungsproblem mit endlich vielen Restriktionen in ein äquivalentes Fazetten-Problem transformiert werden kann. Auf der Grundlage von linearer Optimierungstechnik wird für das Fazetten-Problem ein neues, endliches Schnittebenenverfahren vorgestellt.

     

Influence of internal degrees of freedom on the structure of one-dimensional systems

Summary The influence of internal degrees of freedom on the behaviour of one-dimensional systems is discussed. For systems with half-filled bands the coupling to internalviz. lattice coordinates decides whether Peierls distortion is caused by intramonomer coordinates or by a lattice coordinate. Thereby the various intramonomer degrees of freedom act cooperatively. We show that there is a small regime of parameters where both kinds of distortion exist simultaneously. For increasing temperature we find that distortions can also move from the lattice coordinate to the intramonomer coordinate.     

Fejér means of functions on noncommutative Vilenkin groups with respect to the character system

Summary It is known that the Fejér means - with respect to the character system of the Walsh, and bounded Vilenkin groups - of an integrable function converge to the function a.e. In this work we discuss analogous problems on the complete product of finite, not necessarily Abelian groups with respect to the character system for functions that are constant on the conjugacy classes. We find that the nonabelian case differs from the commutative case. We prove the a.e. convergence of the (C,1) means of the Fourier series of square integrable functions. We also prove the existence of a function f∊L^q for some q >1 such that sup |σ_n f | = + ∞ a.e. This is a sharp contrast between the Abelian and the nonabelian cases.     

Application of tris-allyl-DOTA in the preparation of DOTA-peptide conjugates

The synthesis of tris-allyl-DOTA starting from cyclen and its application in the preparation of DOTA-peptide conjugates is reported. Clinically important conjugates such as DOTA-Tyr³-octreotide (DOTA-TOC), DOTA-Tyr³-octreotate (DOTA-TATE) as well as a DOTA-RGD peptide were synthesized in high yields with Fmoc solid phase peptide synthesis. The final, extremely reliable de-allylation was achieved on solid phase by different methods identifying morpholine/Pd(0) as the most suitable one obtaining all DOTA peptide conjugates in high yields. All DOTA-peptides were purified by reversed phase HPLC and structural identity was proved using MALDI-TOF mass spectrometry.     

On the Point-Particle (Newtonian) Limit¶of the Non-Linear Hartree Equation

We consider the nonlinear Hartree equation describing the dynamics of weakly interacting non-relativistic Bosons. We show that a nonlinear M?ller wave operator describing the scattering of a soliton and a wave can be defined. We also consider the dynamics of a soliton in a slowly varying background potential W(ɛx). We prove that the soliton decomposes into a soliton plus a scattering wave (radiation) up to times of order ɛ⁻¹. To leading order, the center of the soliton follows the trajectory of a classical particle in the potential W(ɛx). Received: 30 June 2000 / Accepted: 25 June 2001