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161.
Radovan Hynek Iva Michalus Pavel Cejnar Jiří Šantrůček Sabina Seidlová Štěpánka Kučková Petra Sázelová Václav Kašička 《Electrophoresis》2021,42(23):2552-2562
Proteomic characterization of alveolar bones in oral surgery represents an analytical challenge due to their insoluble character. The implementation of a straightforward technique could lead to the routine use of proteomics in this field. This work thus developed a simple technique for the characterization of bone tissue for human maxillary and mandibular bones. It is based on the direct in-bone tryptic digestion of proteins in both healthy and pathological human maxillary and mandibular bone samples. The released peptides were then identified by the LC-MS/MS. Using this approach, a total of 1120 proteins were identified in the maxillary bone and 1151 proteins in the mandibular bone. The subsequent partial least squares–discrimination analysis (PLS-DA) of protein data made it possible to reach 100% discrimination between the samples of healthy alveolar bones and those of the bone tissue surrounding the inflammatory focus. These results indicate that the in-bone protein digestion followed by the LC-MS/MS and subsequent statistical analysis can provide a deeper insight into the field of oral surgery at the molecular level. Furthermore, it could also have a diagnostic potential in the differentiation between the proteomic patterns of healthy and pathological alveolar bone tissue. Data are available via ProteomeXchange with the identifier PXD026775. 相似文献
162.
Avcıbaşı Uğur Türkyarar Taner Karadağ Ayşegül Bakan Buket Yavaşoğlu Nefise Ülkü Karabay Kuşat Kevser Akgöl Sinan Gülcemal Derya Tekin Volkan Müftüler Fazilet Zümrüt Biber Topal Gökcen Parlak Yasemin Gümüşer Fikriye Gül 《Journal of Radioanalytical and Nuclear Chemistry》2021,329(2):511-525
Journal of Radioanalytical and Nuclear Chemistry - The aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties.... 相似文献
163.
164.
Oscar Hernandez Peter Pulay Philippe Maître Béla Paizs 《Journal of the American Society for Mass Spectrometry》2014,25(9):1511-1514
Using quantum chemical calculations and infrared multiphoton dissociation (IRMPD) spectroscopy in the fingerprint and X-H stretching regions, we demonstrate here that the all-Ala b 6 fragment ion features a macrocyclic structure with C2 symmetry. For this structure, the ionizing proton is equally shared by the Ala(1) and Ala(4) amide oxygens in a Zundel-type symmetric (X…H+…X) H-bond. Figure
? 相似文献
165.
Cătălin Tănase Lucia Odochian Tiberius Balaeş Gabriela Lisă Daniel Gherca Aurel Pui 《Journal of Thermal Analysis and Calorimetry》2014,115(1):947-953
This paper is aimed to analyse the thermal behaviour in air of edible mushrooms through nonisothermal (TG, DTG, DTA) and calorimetric (Berthelot calorimeter) methods. The studied mushrooms were Pleurotus ostreatus spontaneously grown and from culture and Agaricus bisporus from culture, currently used in alimentation but insufficiently investigated from this point of view. The analysis of TG–DTG–DTA curves has indicated that the degradation mechanism is complex and characteristic to every species and major differences between the cap and the stipe of investigated mushrooms have not been recorded. These species are thermally stable in the range of 30–160 °C. The thermal stability in terms of initial degradation temperature (T i °C) and the temperature corresponding to the conversion grade (T α=0.03 °C) indicate that the stipe has a thermal stability close to the cap one and that the cultivated mushrooms are more thermally stable than those spontaneously grown. The obtained results concerning the combustion of the sample using Berthelot calorimeter are in accordance with the TG–DTG–DTA analysis. The residue obtained is a measure of the mineral content and is quantitatively close. 相似文献
166.
Damien Hueber Marie Hoffmann Dr. Benoît Louis Prof. Dr. Patrick Pale Dr. Aurélien Blanc 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(14):3903-3907
Gold(I)‐polyoxometalate hybrid complexes 1 – 4 ([PPh3AuMeCN]xH4?xSiW12O40, x=1–4) were synthesized and characterized. The structure of the primary gold(I)–polyoxometalate 1 (x=1) was fully ascertained by XRD, FTIR, 31P and 29Si magic‐angle spinning (MAS) NMR, mass spectroscopy, and SEM–energy dispersive X‐ray spectroscopy (EDX) techniques. Moreover, this complex exhibited better catalytic activity and selectivity compared with standard, homogeneous, gold catalysts in the new rearrangement of propargylic gem‐diesters. 相似文献
167.
Spin‐State Ordering on One Sub‐lattice of a Mononuclear Iron(III) Spin Crossover Complex Exhibiting LIESST and TIESST
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Dr. Kevin D. Murnaghan Dr. Chiara Carbonera Dr. Loic Toupet Dr. Michael Griffin Dr. Marinela M. Dîrtu Dr. Cédric Desplanches Prof. Dr. Yann Garcia Prof. Eric Collet Prof. Jean‐François Létard Dr. Grace G. Morgan 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(19):5613-5618
The two‐step spin crossover in mononuclear iron(III) complex [Fe(salpm)2]ClO4 ? 0.5 EtOH ( 1 ) is shown to be accompanied by a structural phase transition as concluded from 57Fe Mössbauer spectroscopy and single crystal X‐ray diffraction, with spin‐state ordering on just one of two sub‐lattices in the intermediate magnetic and structural phase. The complex also exhibits thermal‐ and light‐induced spin‐state trapping (TIESST and LIESST), and relaxation from the LIESST and TIESST excited states occurs via the broken symmetry intermediate phase. Two relaxation events are evident in both experiments, that is, two T(LIESST) and two T(TIESST) values are recorded. The change in symmetry which accompanies the TIESST effect was followed in real time using single crystal diffraction. After flash freezing at 15 K the crystal was warmed to 40 K at which temperature superstructure reflections were observed to appear and disappear within a 10 000 s time range. In the frame of the international year of crystallography, these results illustrate how X‐ray diffraction makes it possible to understand complex ordering phenomena. 相似文献
168.
Back Cover: Assessment of DNA Binding to Human Rad51 Protein by using Quartz Crystal Microbalance and Atomic Force Microscopy: Effects of ADP and BRC4‐28 Peptide Inhibitor (ChemPhysChem 17/2014)
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169.
Adrian Pîrnău Mihaela Mic Mircea Bogdan Ioan Turcu 《Journal of inclusion phenomena and macrocyclic chemistry》2014,79(3-4):283-289
The inclusion of local anesthetic drug procaine hydrochloride by β-cyclodextrin was investigated by 1D and 2D proton NMR spectroscopy and isothermal titration calorimetry (ITC) at 298 K. The stoichiometry of the complex was determinate by the method of continuous variation, using the chemical induced shift of both host and guest protons. The association constant K, of the obtained complex was calculated and found to be 293.17 M?1. Rotating frame NOE spectroscopy, was used to ascertain the solution geometry of the host–guest complex. The result reveals that the procaine molecule penetrates into the β-cyclodextrin cavity with the aromatic ring. The energetics of complexation process is investigated by ITC technique. The analysis indicates that the complexation of procaine by β-CD is an exothermic process and show that both enthalpy and entropy contribute to the binding process. The obtained value for the association constant is in good agreement with that obtained from NMR. 相似文献
170.
Xavier Cattoën Achraf Noureddine Jonas Croissant Nirmalya Moitra Kristýna Bürglová Jana Hodačová Olivia de los Cobos Martine Lejeune Fabrice Rossignol Delphine Toulemon Sylvie Bégin-Colin Benoît P. Pichon Laurence Raehm Jean-Olivier Durand Michel Wong Chi Man 《Journal of Sol-Gel Science and Technology》2014,70(2):245-253
The combination of the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction with sol–gel processing enables the versatile preparation of sol–gel materials under different shapes with targeted functionalities through a diversity-oriented approach. In this account, the development of the CuAAC reaction under anhydrous conditions for the synthesis of sol–gel precursors and for the assembling of magnetic nanoparticles on self-assembled monolayers is related, as well as the use of the classical CuAAC methodologies for the functionalization of mesoporous silica nanoparticles and microdots arrays. Coupling CuAAC and Sol–Gel will result in simplified preparations of multifunctional materials with controlled morphologies. 相似文献