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141.
K. E. Mochalov O. A. Ustinova S. A. Strel’tsov S. L. Grokhovskii A. L. Zhuze I. R. Nabiev A. V. Sukhanova V. A. Oleinikov 《Optics and Spectroscopy》2002,93(4):493-500
Topotecan (TPT), a water-soluble derivative of camptothecin (inhibitor of human DNA topoiomerase I), has found wide application in cancer chemotherapy. The central problem in using topotecan is the presence of lactone rings in its molecules, which undergo hydrolysis at a physiological pH yielding an inactive and even toxic form of the drug. The analysis of Raman spectra of TPT in H2O and D2O solutions made it possible to assign the spectral bands to the vibrations of particular molecular groups. Spectral features indicative of the opening of the lactone rings of the TPT molecules, deprotonation of the hydroxyl groups in their quinoline fragments, and of possible participation of the hydroxyl and carbonyl groups in H bonding are found. The data obtained are necessary to study the molecular mechanisms of TPT-DNA interaction and the formation of ternary complexes between TPT, DNA, and DNA topoisomerase I. 相似文献
142.
G. E. Volovik 《JETP Letters》2002,76(5):240-244
An analogue of a black hole can be realized in the low-temperature laboratory. The horizon can be constructed for “relativistic” ripplons (surface waves) living on the brane. The brane is represented by the interface between two superfluid liquids, 3He-A and 3He-B, sliding along each other without friction. A similar experimental arrangement was recently used for the observation and investigation of the Kelvin-Helmholtz type of instability in superfluids [1]. The shear-flow instability in superfluids is characterized by two critical velocities. The lowest threshold measured in recent experiments [1] corresponds to the appearance of the ergoregion for ripplons. In the modified geometry, this will give rise to the black-hole event horizon in the effective metric experienced by ripplons. In the region behind the horizon, the brane vacuum is unstable due to interaction with the higher-dimensional world of bulk superfluids. The time of the development of instability can be made very long at low temperature. This will allow us to reach and investigate the second critical velocity—the proper Kelvin-Helmholtz instability threshold. The latter corresponds to the singularity inside the black hole, where the determinant of the effective metric becomes infinite. 相似文献
143.
144.
We use the adiabatic hyperspheric expansion and the Faddeev decomposition of the wave function with only s-waves. We derive for a fixed hyperradius an integro-differential equation for the angular eigenvalue and wave function. The
correlations lower the interaction energy for N = 20 by about a factor of 5.
Received October 22, 2001; accepted for publication November 5, 2001 相似文献
145.
An implicit quasi-monotone second-order accurate method is proposed for analyzing the spiral Couette flow of a rarefied gas between coaxial cylinders. The basic advantages of the method over the conventional method of stationry iterations are that the former is conservative with respect to the collision integral, has a simple software implementation for any types of boundary conditions, and applies to a wide range of Knudsen numbers. 相似文献
146.
The purpose of this paper is to investigate problems of the Navier-Stokes approximation to kinetic equations in terms of the
so-called Chapman-Enskog projection. One considers properties of the Chapman-Enskog projection for the Cauchy problem for
moment approximations of the kinetic equation and primarily the Chapman-Enskog projection for the Boltzmann-Peierls kinetic
equation. The existence of the Chapman-Enskog projection for the Cauchy problem is proved for the phase space of conservative
variables (phenomena of nonlinear diffusion) and for the phase space of physical variables (the second sound projection).
__________
Translated from Trudy Seminara imeni I. G. Petrovskogo, No. 25, pp. 184–225, 2005. 相似文献
147.
J. Gasser M.A. Ivanov E. Lipartia M. Mojzis A. Rusetsky 《The European Physical Journal C - Particles and Fields》2002,26(1):13-34
We investigate the ground-state energy of the atom (pionic hydrogen) in the framework of QCD + QED. In particular, we evaluate the strong energy-level shift. We perform
the calculation at next-to-leading order in the low-energy expansion in the framework of the relevant effective field theory.
The result provides a relation between the strong energy shift and the pion-nucleon S-wave scattering lengths - evaluated in pure QCD - at next-to-leading order in isospin-breaking and in the low-energy expansion.
We compare our result with available model calculations.
Received: 11 June 2002 / Published online: 9 October 2002 相似文献
148.
O. Kortner M.P. Locher V.E. Markushin P. Weber O. Wigger 《The European Physical Journal C - Particles and Fields》2002,25(3):353-360
We study correlations in the exclusive reaction at rest with complete reconstruction of the kinematics for each event. The inclusive distribution is fairly flat at small
invariant mass of the pion pair while a small enhancement in the double differential distribution is observed for small invariant
masses of both pion pairs. Dynamical models with resonances in the final state are shown to be consistent with the data while
the stochastic HBT mechanism is not supported by the present findings.
Received: 26 February 2002 / Revised version: 22 July 2002 / Published online: 30 August 2002 相似文献
149.
An analysis of events in the tunneling junction shows that the interaction of one-electron processes in a many-electron system may be a source of scale-invariant low-frequency fluctuations of conductivity (the interaction consists in that the quantum probability of an electron transition depends on fast random changes in the environment in the course of the transition, including the changes caused by analogous transitions). The theory relates flicker fluctuations in the tunneling conductivity to the discrete character of the spectrum of electron states and explains the nonlinearity of the noise-current characteristic observed in nanocomposites. 相似文献
150.
We consider Markov processes built from pasting together pieces of strong Markov processes which are killed at a position
dependent rate and connected via a transition kernel. We give necessary and sufficient conditions for local absolute continuity
of probability laws for such processes on a suitable path space and derive an explicit formula for the corresponding likelihood
ratio process. The main tool is the consideration of the process between successive jumps – what we call ‘elementary experiments’
– and criteria for absolute continuity of laws of the process there. We apply our results to systems of branching diffusions
with interactions and immigrations.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献