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排序方式: 共有173条查询结果,搜索用时 15 毫秒
61.
K.R. Kazmi B.S. Komal F.A. Khan Pankaj Mansotra 《Applied mathematics and computation》2009,215(2):716-726
In this paper, using the concept of P-η-proximal-point mapping introduced by Kazmi and Bhat [11], we study the existence and sensitivity analysis of the solution set of a system of parametric general quasi-variational-like inequality problems in uniformly smooth Banach spaces. Further under suitable conditions, we discuss the Lipschitz continuity of the solution set with respect to the parameters. The approach used in this paper may be treated as an extension and unification of approaches for studying sensitivity analysis for various important classes of variational inequalities given in [1,2,4,12,14–16,21–24]. 相似文献
62.
Komal R. Parmar Kalpesh A. Patel Sunny R. Shah Navin R. Sheth 《Journal of inclusion phenomena and macrocyclic chemistry》2009,65(3-4):263-268
Lamotrigine (LMN) is an antiepileptic drug, with poor aqueous solubility, which might lead to erratic bioavailability. The objective of the present work was to improve the dissolution characteristics of the LMN using Hydroxy propyl β-cyclodextrin (HP β-CD), which might offer reliable bioavailability. The phase solubility profile was classified as A L -type, revealing 1:1 stoichiometric complexation, with a stability constant (Ks) of 573 M?1. Binary systems of LMN and HP β-CD were prepared in different molar ratios (1:1, 1:2, 1:3 and 1:4) by kneading method. The binary systems were characterized by Fourier Transform Infrared (FT-IR) Spectroscopy, Differential Scanning Calorimetry (DSC) and Powder X-ray Diffraction Analysis (PXRD). Results revealed that in the kneaded products the entire drug was entrapped inside the HP β-CD cavity and reduction in drug crystallinity also took place, which may be responsible for improved dissolution characteristics as compared to that of the pure drug as depicted from the dissolution studies. 相似文献
63.
The main purpose of this paper is to investigate energy bounds in the context of f(R, G) gravity. To meet this aim, we choose static spherically symmetric spacetime in f(R, G) gravity to develop the field equations. We select three different models of f(R, G) gravity, which are thoroughly discussed in the literature. Firstly, the inequalities are formulated using energy bounds and then viability of the considered models are checked respectively. Graphical analysis show that specific f(R, G) gravity models are satisfied under suitable values of model parameters. It is shown that in a certain case energy bounds are satisfied expect SEC, which supports the late time acceleration expansion of unverse. 相似文献
64.
Oliver M Ahmad A Kamaly N Perouzel E Caussin A Keller M Herlihy A Bell J Miller AD Jorgensen MR 《Organic & biomolecular chemistry》2006,4(18):3489-3497
Cellular entry of imaging probes, such as contrast agents for magnetic resonance imaging (MRI), is a key requirement for many molecular imaging studies, particularly imaging intracellular events and cell tracking. Here, we describe the successful development and in vitro analysis of MAGfect, a novel liposome formulation containing a lipidic gadolinium contrast agent for MRI, Gd-DOTA-Chol , designed to enter and label cells. Liposome formulation and cell incubation time were optimised for maximum cellular uptake of the imaging probe in a variety of cell lines. MRI analysis of cells incubated with MAGfect showed them to be highly MRI active. This formulation was examined further for cytotoxicity, cell viability and mechanism of cell labelling. One of the key advantages of using MAGfect as a labelling vehicle arises from its potential for additional functions, such as concomitant drug or gene delivery and fluorescent labelling. The gadolinium liposome was found to be an effective vehicle for transport of plasmid DNA (pDNA) into cells and expression levels were comparable to the commercial transfection agent Trojene. 相似文献
65.
Muhammad Ajmal Shah Ayesha Hamid Hafiza Ishmal Faheem Azhar Rasul Tourki A. S. Baokbah Muhammad Haris Rimsha Yousaf Uzma Saleem Shabnoor Iqbal Maria Silvana Alves Zahid Khan Ghulam Hussain Ifat Alsharfi Haroon Khan Philippe Jeandet 《Molecules (Basel, Switzerland)》2022,27(21)
Polydatin or 3-O-β-d-resveratrol-glucopyranoside (PD), a stilbenoid component of Polygonum cuspicadum (Polygonaceae), has a variety of biological roles. In traditional Chinese medicine, P. cuspicadum extracts are used for the treatment of infections, inflammation, and cardiovascular disorders. Polydatin possesses a broad range of biological activities including antioxidant, anti-inflammatory, anticancer, and hepatoprotective, neuroprotective, and immunostimulatory effects. Currently, a major proportion of the population is victimized with cervical lung cancer, ovarian cancer and breast cancer. PD has been recognized as a potent anticancer agent. PD could effectively inhibit the migration and proliferation of ovarian cancer cells, as well as the expression of the PI3K protein. The malignancy of lung cancer cells was reduced after PD treatments via targeting caspase 3, arresting cancer cells at the S phase and inhibiting NLRP3 inflammasome by downregulation of the NF-κB pathway. This ceases cell cycle, inhibits VEGF, and counteracts ROS in breast cancer. It also prevents cervical cancer by regulating epithelial-to-mesenchymal transition (EMT), apoptosis, and the C-Myc gene. The objective of this review is thus to unveil the polydatin anticancer potential for the treatment of various tumors, as well as to examine the mechanisms of action of this compound. 相似文献
66.
67.
Journal of Mathematical Chemistry - Recently, the two-dimensional elliptic singularly perturbed boundary value problems have received attention. These problems have not been much explored... 相似文献
68.
Malik Adnan Nafees Ayesha Ali Akram Butt Muhammad Naeem 《The European Physical Journal C - Particles and Fields》2022,82(2):1-12
The European Physical Journal C - Much theoretical effort and automatization are required to confront new physics models with experimental data for many types of particle reactions at future... 相似文献
69.
70.
The blend membranes of polystyrene-block-polyisoprene-block-polystyrene and polyethylene-block-poly(ethylene glycol)-block-polycaprolactone were designed using the phase inversion technique. The poly(methyl methacrylate)-coated gold nanoparticles are around 40–50 nm in size. The honeycomb-shaped nanopores were uniformly dispersed in polystyrene-block-polyisoprene-block-polystyrene/polyethylene-block-poly(ethylene glycol)-block-polycaprolactone/poly(methyl methacrylate)-coated gold nanoparticles blend membranes. There was a 16% increase in tensile strength and a 33% increase in tensile modulus of polystyrene-block-polyisoprene-block-polystyrene/polyethylene-block-poly(ethylene glycol)-block-polycaprolactone/poly(methyl methacrylate)-coated gold nanoparticles 1 relative to the neat membrane. With 1 wt% nanoparticles, the membrane showed a higher water flux of 59.2 mL cm?2 min?1 and a salt rejection ratio of 25.4%, while the polystyrene-block-polyisoprene-block-polystyrene/polyethylene-block-poly(ethylene glycol)-block-polycaprolactone membrane without poly(methyl methacrylate)-coated gold nanoparticles had lower flux (43.8 mL cm?2 min?1) and salt rejection (18.5%). 相似文献